公开(公告)号：EP1737465A1

公开(公告)日：2007-01-03

申请号：EP05737742.6

申请日：2005-04-18

Applicant: LOMA LINDA UNIVERSITY

Inventor： BALDWIN, Dalton D.

IPC: A61K31/53 ,  A61K31/495 ,  A61K31/497 ,  A61K31/44 ,  A61K31/40

CPC classification number: A61K31/40 ,  A61K31/44 ,  A61K31/495 ,  A61K31/497 ,  A61K31/519 ,  A61K31/53 ,  A61K2300/00

Abstract: A method of decreasing renal ischemic damage comprising a) identifying an organism having a kidney that is susceptible to renal ischemic damage from an ischemic event; and b) administering to the organism one or more than one effective dose of an agent prior to the ischemic event; where administering to the organism the one or more than one effective dose of the agent serves to at least partially protect the organism's kidney from damage during a subsequent ischemic event. A composition for decreasing renal ischemic damage comprising one or more than one phosphodiesterase inhibitor, and one or more than one HMG-CoA reductase inhibitor.

公开(公告)号：EP2432372A1

公开(公告)日：2012-03-28

申请号：EP10786556.0

申请日：2010-05-18

Applicant: Loma Linda University

Inventor： BALDWIN, Dalton D. ,  RICHARDS, Gideon

IPC: A61B1/313

CPC classification number: A61B17/2909 ,  A61B17/29 ,  A61B17/3423 ,  A61B18/1482 ,  A61B2017/292 ,  A61B2017/2931 ,  A61B2017/2936 ,  A61B2017/294 ,  A61B2018/00083 ,  A61B2018/00107 ,  A61B2018/00595 ,  A61B2018/1422 ,  A61B2217/005 ,  A61M1/008

Abstract: A device for use in performing minimally invasive surgery. A system for performing minimally invasive surgery comprising the device according to the present invention. A method for performing minimally invasive surgery.

公开(公告)号：WO2010144219A1

公开(公告)日：2010-12-16

申请号：PCT/US2010/035312

申请日：2010-05-18

Applicant: LOMA LINDA UNIVERSITY ,  BALDWIN, Dalton D. ,  RICHARDS, Gideon

Inventor： BALDWIN, Dalton D. ,  RICHARDS, Gideon

IPC: A61B1/313

CPC classification number: A61B17/2909 ,  A61B17/29 ,  A61B17/3423 ,  A61B18/1482 ,  A61B2017/292 ,  A61B2017/2931 ,  A61B2017/2936 ,  A61B2017/294 ,  A61B2018/00083 ,  A61B2018/00107 ,  A61B2018/00595 ,  A61B2018/1422 ,  A61B2217/005 ,  A61M1/008

Abstract: A device for use in performing minimally invasive surgery A system for performing minimally invasive surgery compπsing the device according to the present invention. A method for performing minimally invasive surgery. According to one embodiment, there is provided a device comprising a user interface comprising: a) a proximal portion, an intermediate portion and a distal portion, where the intermediate portion connects the proximal portion to the distal portion; and b) a pushrod, a shaft and a spring, where the distal portion is configured to reversibly mate with a working end.

Abstract translation: 用于执行微创手术的装置用于执行根据本发明的装置的微创手术的系统。 一种执行微创手术的方法。 根据一个实施例，提供了一种包括用户界面的设备，包括：a）近端部分，中间部分和远端部分，其中中间部分将近端部分连接到远端部分; 以及b）推杆，轴和弹簧，其中所述远端部分构造成可与工作端可逆地配合。

公开(公告)号：WO2005102348A1

公开(公告)日：2005-11-03

申请号：PCT/US2005/013175

申请日：2005-04-18

Applicant: LOMA LINDA UNIVERSITY ,  BALDWIN, Dalton D.

Inventor： BALDWIN, Dalton D.

IPC: A61K31/53

CPC classification number: A61K31/40 ,  A61K31/44 ,  A61K31/495 ,  A61K31/497 ,  A61K31/519 ,  A61K31/53 ,  A61K2300/00

Abstract: A method of decreasing renal ischemic damage comprising a) identifying an organism having a kidney that is susceptible to renal ischemic damage from an ischemic event; and b) administering to the organism one or more than one effective dose of an agent prior to the ischemic event; where administering to the organism the one or more than one effective dose of the agent serves to at least partially protect the organism's kidney from damage during a subsequent ischemic event. A composition for decreasing renal ischemic damage comprising one or more than one phosphodiesterase inhibitor, and one or more than one HMG-CoA reductase inhibitor.

Abstract translation: 一种减少肾缺血损伤的方法，包括：a）从缺血事件鉴定具有肾脏缺血损伤易感肾的生物; 和b）在缺血事件之前向所述生物体施用一种或多于一种有效剂量的药剂; 其中向生物体施用一种或多于一种有效剂量的试剂用于在随后的缺血事件期间至少部分地保护生物体的肾脏免受损伤。 包含一种或多于一种磷酸二酯酶抑制剂和一种或多于一种HMG-CoA还原酶抑制剂的用于减少肾缺血损伤的组合物。