公开(公告)号：AU7476498A

公开(公告)日：1998-11-27

申请号：AU7476498

申请日：1998-05-08

Applicant: LOMA LINDA UNIVERSITY AND MEDI

Inventor： DIAMOND DAVID ,  NEHLSEN-CANNARELLA SANDRA ,  FAGOAGA OMAR R ,  SZALAY ALADAR

IPC: A01K67/027 ,  C12N9/10 ,  C12N15/54 ,  C12Q1/68 ,  C12N5/10

Abstract: This invention relates to histo-blood group O alleles of baboon. The major O allele retains identifying sequence characteristics of the baboon A allele. Other alleles, including a B-like allele, are also disclosed herein. The O alleles of baboon are closer in sequence similarity to the baboon A and B alleles than are any of the baboon ABO alleles to the human alleles of the ABO locus. This invention also provides materials and methods for identifying O alleles, and carriers of O alleles, as well as methods for producing baboons and baboon cells, tissues, and organs having a group O phenotype. Group O baboons, cells, tissues, and organs of the invention are useful for xenotransplantation.