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    Nanodosimeter based on single ion detection
    3.
    发明专利
    Nanodosimeter based on single ion detection 未知

    公开(公告)号：AU2011202033B2

    公开(公告)日：2014-04-24

    申请号：AU2011202033

    申请日：2011-05-03

    Applicant: UNIV LOMA LINDA ,  YEDA LTD

    Inventor： BASHKIROV VLADIMIR ,  BRESKIN AMOS ,  CHECHIK RACHEL ,  GARTY GUY ,  MILLIGAN JAMIE ,  SCHULTE REINHARD W ,  SHCHEMELININ SERGI

    IPC: B01D59/44 ,  H01J49/00

    Abstract: Abstract A dosimetry method comprising the steps of providing a volume of gas, forming a sensitive volume within the volume of gas such that, on average, a dose of radiation incident on the volume of gas yields a response from the sensitive volume that is substantially equivalent to a response of a biological sample to the dose of radiation, positioning the volume of gas so as to receive the dose of radiation, detecting one or more ions from the sensitive volume resulting from the dose of radiation, and generating data from the one or more detected ions, the data representative of an estimation of the response of the biological sample to the dose of radiation.

    NANODOSIMETER BASED ON SINGLE ION DETECTION
    4.
    发明专利
    NANODOSIMETER BASED ON SINGLE ION DETECTION 未知

    公开(公告)号：CA2406697C

    公开(公告)日：2007-10-02

    申请号：CA2406697

    申请日：2001-04-27

    Applicant: UNIV LOMA LINDA ,  YEDA LTD

    Inventor： SCHULTE REINHARD W ,  BASHKIROV VLADIMIR ,  SHCHEMELININ SERGI ,  BRESKIN AMOS ,  MILLIGAN JAMIE ,  GARTY GUY ,  CHECHIK RACHEL

    IPC: G01T1/02 ,  C12N13/00 ,  G01N27/64 ,  G01Q60/00 ,  G01T1/185 ,  G01T1/29 ,  H01J47/02 ,  H01J49/40

    Abstract: A nanodosimeter device (15) for de-tecting positive ions induced in a sensitive gas volume by a radiation field of primary particle, comprising an ionization chamber (10) for holding the sensitive gas volume to be irradiated by the radiation field of primary particles, an ion counter system connected to the ionization chamber (10) for detecting the positive ions which pass through the aperture opening and arrive at the ion counter (12) at an arrival time, a particle tracking system for position-sensitive detection of the primary particles passing through the sensitive gas volume, and a data acquisition system capable of coordinating the readout of all data signals and of performing data analysis correlating the arrival time of the positive ions detected by the ion counter system relative to the position sensitive data of primary particles detected by the particle tracking system. The invention further includes the use of the nanodosimeter for method of calibrating radiation exposure with damage to a nucleic acid within a sample. A volume of tissue-equivalent gas is radiated with a radiation field to induce positive ions. The resulting positive ions are measured and compared with a determination of presence or extent of damage resulting from irradiating a nucleic acid sample with an equivalent dose of radiation.

    NANODOSIMETER BASED ON SINGLE ION DETECTION
    6.
    发明公开
    NANODOSIMETER BASED ON SINGLE ION DETECTION 有权
    NANODOSIMETER AUF EINZELIONENDETEKTIERUNG BASIEREND

    公开(公告)号：EP1289627A4

    公开(公告)日：2003-09-03

    申请号：EP01941462

    申请日：2001-04-27

    Applicant: UNIV LOMA LINDA ,  YEDA LTD

    Inventor： BASHKIROV VLADIMIR ,  SCHULTE REINHARD W ,  SHCHEMELININ SERGI ,  BRESKIN AMOS ,  CHECHIK RACHEL ,  GARTY GUY ,  MILLIGAN JAMIE

    IPC: G01N27/64 ,  G01Q60/00 ,  H01J49/40 ,  G01T1/02

    CPC classification number: H01J49/40 ,  G01N27/64

    Abstract: A nanodosimeter device (15) for detecting positive ions induced in a sensitive gas volume by a radiation field of primary particle, comprising an ionization chamber (10) for holding the sensitive gas volume to be irradiated by the radiation field of primary particles; an ion counter system connected to the ionization chamber (10) for detecting the positive ions which pass through the aperture opening and arrive at the ion counter (12) at an arrival time; a particle tracking system for position-sensitive detection of the primary particles passing through the sensitive gas volume; and a data acquisition system capable of coordinating the readout of all data signals and of performing data analysis correlating the arrival time of the positive ions detected by the ion counter system relative to the position sensitive data of primary particles detected by the particle tracking system. The invention further includes the use of the nanodosimeter for method of calibrating radiation exposure with damage to a nucleic acid within a sample. A volume of tissue-equivalent gas is radiated with a radiation field to induce positive ions. The resulting positive ions are measured and compared with a determination of presence or extent of damage resulting from irradiating a nucleic acid sample with an equivalent dose of radiation.

    Abstract translation: 1。一种用于检测由初级粒子的辐射场在敏感气体体积中感应的正离子的纳米测压装置（15），包括用于保持要由初级粒子的辐射场照射的敏感气体体积的电离室（10） 连接到电离室（10）的离子计数器系统，用于检测在到达时间穿过孔径开口并到达离子计数器（12）的正离子; 用于位置敏感检测穿过敏感气体体积的初级颗粒的颗粒跟踪系统; 以及数据采集系统，其能够协调所有数据信号的读出并且执行数据分析，使得由离子计数器系统检测到的正离子的到达时间与由粒子追踪系统检测到的初级粒子的位置敏感数据相关。 本发明进一步包括纳米剂量计用于校准辐射暴露并对样品内的核酸造成损害的方法的用途。 一定体积的组织等效气体用辐射场辐射以诱导正离子。 测量得到的正离子并与通过用相等剂量的辐射照射核酸样品所导致的损伤的存在或程度的确定进行比较。

    Nanodosimeter based on single ion detection
    10.
    发明专利
    Nanodosimeter based on single ion detection 未知

    公开(公告)号：AU2007216655A1

    公开(公告)日：2007-09-27

    申请号：AU2007216655

    申请日：2007-09-06

    Applicant: UNIV LOMA LINDA ,  YEDA LTD

    Inventor： BRESKIN AMOS ,  GARTY GUY ,  SCHULTE REINHARD W ,  CHECHIK RACHEL ,  BASHKIROV VLADIMIR ,  MILLIGAN JAMIE ,  SHCHEMELININ SERGI

    IPC: B01D59/44 ,  H01J49/00

    Abstract: Abstract A dosimetry method comprising the steps of providing a volume of gas, forming a sensitive volume within the volume of gas such that, on average, a dose of radiation incident on the volume of gas yields a response from the sensitive volume that is substantially equivalent to a response of a biological sample to the dose of radiation, positioning the volume of gas so as to receive the dose of radiation, detecting one or more ions from the sensitive volume resulting from the dose of radiation, and generating data from the one or more detected ions, the data representative of an estimation of the response of the biological sample to the dose of radiation.

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