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公开(公告)号：WO2019212349A3
公开(公告)日：2019-11-07
申请号：PCT/NL2019/050262
申请日：2019-05-02
Applicant: LUMICKS TECHNOLOGIES B.V. , STICHTING VU
Inventor： WUITE, Gijs Jan Lodewijk , SORKIN, Raya , KAMSMA, Douwe , SITTERS, Gerrit , PETERMAN, Erwin Johannes Gerard , BERGAMASCHI, Giulia , DE GROOT, Mattijs
Abstract: A method for probing mechanical properties of cellular bodies includes: providing a plurality of particles in a fluid medium contained in a holding space of a sample holder, each of the plurality of particle being attached to a cellular body; generating a resonant bulk acoustic wave in the holding space, the resonant bulk acoustic wave exerting an acoustic force on each of the plurality of particles, each of the plurality of particles having an acoustic contrast factor and a size, the acoustic contrast factor and the size being selected such that the force exerted on a particle is larger than the force exerted on the cellular body to which the particle is attached; measuring a displacement of a particle in response to the exertion of the force on the particle, the measured displacement being associated with a mechanical property of the cellular body attached to the particle.
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公开(公告)号：WO2019212349A2
公开(公告)日：2019-11-07
申请号：PCT/NL2019/050262
申请日：2019-05-02
Applicant: LUMICKS TECHNOLOGIES B.V. , STICHTING VU
Inventor： WUITE, Gijs Jan Lodewijk , SORKIN, Raya , KAMSMA, Douwe , SITTERS, Gerrit , PETERMAN, Erwin Johannes Gerard , BERGAMASCHI, Giulia , DE GROOT, Mattijs
Abstract: A method for probing mechanical properties of cellular bodies is described wherein the method includes: providing a plurality of particles in a fluid medium contained in a holding space of a sample holder, each of the plurality of particles being attached to a cellular body and each cellular body being positioned on a surface of the holding space; generating a resonant bulk acoustic wave in the holding space, the resonant bulk acoustic wave exerting an acoustic force on each of the plurality of particles in a direction away from the surface of the holding space or in a direction towards the surface of the holding space, each of the plurality of particles having an acoustic contrast factor and a size, the acoustic contrast factor and the size being selected such that the force exerted on a particle is larger than the force exerted on the cellular body to which the particle is attached; and, for at least part of the particles attached to the cellular bodies, measuring a displacement of a particle in response to the exertion of the force on the particle, the measured displacement being associated with at least one mechanical property of the cellular body attached to the particle.
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公开(公告)号：EP3788360A2
公开(公告)日：2021-03-10
申请号：EP19796362.2
申请日：2019-05-02
Applicant: Lumicks Technologies B.V.
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