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    A NOVEL FAMILY OF POLLEN PROTEINASES, METHODS OF USE THEREOF AND COMPOSITIONS DERIVED THEREFROM
    5.
    发明申请
    A NOVEL FAMILY OF POLLEN PROTEINASES, METHODS OF USE THEREOF AND COMPOSITIONS DERIVED THEREFROM 审中-公开
    一种新型的蛋白质蛋白质，其使用方法及其衍生物

    公开(公告)号：WO1995000850A1

    公开(公告)日：1995-01-05

    申请号：PCT/US1994006880

    申请日：1994-06-17

    Applicant: LXR BIOTECHNOLOGY INC. ,  THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. ,  TRAVIS, James ,  BARR, Philip, J.

    Inventor： LXR BIOTECHNOLOGY INC. ,  THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

    IPC: G01N33/573

    CPC classification number: C12N9/50 ,  A61K39/00

    Abstract: A novel family of proteins has been identified. The proteins are derived from allergenic pollens and exhibit serine-proteinase-like activity. The proteins have a molecular weight of about 85-95 kD as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis; and a molecular weight of about 67 kD as determined by Fast Protein Liquid Chromatography. The proteins are resistant to inhibition by alpha -2-macroglobulin, alpha -1-proteinase inhibitor, trypsin inhibitors and are sensitive to inhibition by phenyl methane sulfonyl fluoride, difluorophenol, benzamidine, antipain, leupeptin and tosyl-L-lysine chloromethyl ketone.

    Abstract translation: 已经鉴定了一个新的蛋白质家族。 蛋白质来源于变应原性花粉，表现出丝氨酸蛋白酶样活性。 蛋白质通过十二烷基硫酸钠聚丙烯酰胺凝胶电泳测定，其分子量约为85-95kD; 和通过Fast Protein Liquid Chromatography测定的约67kD的分子量。 蛋白质对α-2-巨球蛋白，α-1-蛋白酶抑制剂，胰蛋白酶抑制剂的抑制具有抗性，并且对苯基甲磺酰氟，二氟苯酚，苯甲脒，抗胰蛋白酶，亮肽素和甲苯磺酰-L-赖氨酸氯甲基酮的抑制敏感。

    METHODS OF IDENTIFYING POTENTIALLY THERAPEUTICALLY EFFECTIVE AGENTS AND CELL STRAINS FOR USE THEREIN
    8.
    发明申请
    METHODS OF IDENTIFYING POTENTIALLY THERAPEUTICALLY EFFECTIVE AGENTS AND CELL STRAINS FOR USE THEREIN 审中-公开
    鉴定潜在有效药物和细胞应用的方法

    公开(公告)号：WO1994025621A1

    公开(公告)日：1994-11-10

    申请号：PCT/US1994004942

    申请日：1994-04-29

    Applicant: LXR BIOTECHNOLOGY INC. ,  TOMEI, L., David

    Inventor： LXR BIOTECHNOLOGY INC.

    IPC: C12Q01/04

    CPC classification number: G01N33/5011 ,  C12N5/0693 ,  C12N2500/20 ,  C12N2503/02 ,  G01N33/5008 ,  G01N33/5014 ,  G01N33/5017 ,  G01N2500/10 ,  G01N2510/00

    Abstract: The present invention is to a method of screening agents for potential therapeutic efficacy. The method comprises exposing a cell strain that is sensitive to known apoptotic agents to said apoptotic agents and to a potential therapeutic agent. The cell strain is then cultured and cells are removed that display diminished adherence. The remaining, adherent, cells are then incubated in the presence of a proteinase to release proteinase sensitive cells. The proteinase sensitive cells are removed to yield proteinase resistant cells and the proteinase sensitive cells are counted. The proteinase resistant cells are then collected and counted. The agent is determined to have potential therapeutic efficacy if the ratio of proteinase sensitive cells to proteinase resistant cells changes relative to a control as a result of the presence of the agent.

    Abstract translation: 本发明是一种筛选药剂的潜在疗效的方法。 该方法包括将对已知凋亡剂敏感的细胞株暴露于所述凋亡剂和潜在的治疗剂。 然后培养细胞株，去除显示减弱的依从性的细胞。 然后将剩余的粘附细胞在蛋白酶的存在下温育以释放蛋白酶敏感细胞。 去除蛋白酶敏感细胞以产生蛋白酶抗性细胞，并计数蛋白酶敏感细胞。 然后收集蛋白酶抗性细胞并计数。 如果蛋白酶敏感细胞与蛋白酶抗性细胞的比例因试剂的存在而相对于对照变化，则该药剂被确定具有潜在的治疗功效。

    WIDE ANGLE SCATTERING DETECTOR
    9.
    发明申请
    WIDE ANGLE SCATTERING DETECTOR 审中-公开
    宽角度散射探测器

    公开(公告)号：WO1996037767A1

    公开(公告)日：1996-11-28

    申请号：PCT/US1996007374

    申请日：1996-05-21

    Applicant: LXR BIOTECHNOLOGY INC.

    Inventor： LXR BIOTECHNOLOGY INC. ,  TOMEI, L., David

    IPC: G01N21/47

    CPC classification number: G01N21/552 ,  G01N15/1463 ,  G01N21/474 ,  G01N21/645 ,  G01N2021/4707 ,  G01N2021/4728 ,  G01N2021/4735

    Abstract: The present invention is a novel apparatus for the detection and analysis of widely scattered light that impinges on a sample target. The presently claimed apparatus operates in conjunction with a light system that focuses light (40) into a sample target (42). The sample target (42) comprises a translucent material that allows internal reflection of light at some given critical angle (i.e. a wide angle). The presently claimed apparatus comprises: a supporting structure (44), said structure supporting said sample target; at least one optical fiber (50) each fiber having a first and a second end, the first end being placed proximate to the side surface of the sample target (42) such that light scattered and transmitted through the side surface proximate to the side surface is collected by the first end; a photomultiplier tube (52) coupled to at least one second end of said optical fibers.

    Abstract translation: 本发明是用于检测和分析入射到样品靶上的广泛散射的光的新型装置。 目前要求保护的装置与将光（40）聚焦到样本目标（42）中的光系统一起工作。 样本目标（42）包括允许在某一特定临界角（即广角）的内部反射的半透明材料。 目前要求保护的装置包括：支撑结构（44），所述结构支撑所述样品靶; 至少一个光纤（50），每个光纤具有第一和第二端，所述第一端靠近所述样品靶（42）的侧表面放置，使得散射并透过靠近所述侧表面的侧表面的光 由第一端收集; 耦合到所述光纤的至少一个第二端的光电倍增管（52）。

    MULTI-CHANNEL ACQUISITION USING INTEGRATING SPHERE
    10.
    发明申请
    MULTI-CHANNEL ACQUISITION USING INTEGRATING SPHERE 审中-公开
    使用集成球员的多通道获取

    公开(公告)号：WO1996037761A1

    公开(公告)日：1996-11-28

    申请号：PCT/US1996006808

    申请日：1996-05-13

    Applicant: LXR BIOTECHNOLOGY INC.

    Inventor： LXR BIOTECHNOLOGY INC. ,  TOMEI, David, L.

    IPC: G01J01/04

    CPC classification number: G01J1/04 ,  G01J1/0488 ,  G01J2001/0481

    Abstract: The present invention is a novel apparatus that employs an integrating sphere (62) as a source of diffused light for multiple PMTs (64). The PMTs (64) are coupled to the integrating sphere (62) to receive diffused light from the integrating sphere (62). An optional faceplate (66) may be employed at the input port of the integrating sphere (62) in order to select certain characteristics of the light according to the characteristics of the faceplate (66).

    Abstract translation: 本发明是采用积分球（62）作为多个PMT（64）的漫射光源的新型装置。 PMT（64）耦合到积分球（62）以接收来自积分球（62）的漫射光。 可以在积分球（62）的输入端口处使用可选的面板（66），以根据面板（66）的特性来选择光的某些特性。

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