公开(公告)号：US20170151280A1

公开(公告)日：2017-06-01

申请号：US15431443

申请日：2017-02-13

Applicant: LifeCuff Technologies Inc.

Inventor： Boris Leschinsky

IPC: A61K35/14 ,  A61N1/36 ,  A61B17/132 ,  A61M1/02 ,  A61M1/34 ,  A61M1/36

CPC classification number: A61K35/14 ,  A61B17/1325 ,  A61M1/0259 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3406 ,  A61M1/36 ,  A61M1/3681 ,  A61M1/3687 ,  A61M1/3693 ,  A61M2205/3306 ,  A61M2205/3368 ,  A61N1/36

Abstract: Treatment methods are described using blood collected from a donor after subjecting thereof to remote conditioning such as remote ischemic conditioning via several episodes of short-term limb occlusion. Blood containing remote conditioning substances or a biologically active preparation containing such substances may be stored and used at a future time to afford a health benefit to the treatment subject. Extraction of remote conditioning substances may be done extracorporeally using dialysis or other blood processing methods following by returning of blood to the donor. Extraction of remote conditioning substances may be done during the time periods of their maximum presence in donor blood.

公开(公告)号：US09611476B2

公开(公告)日：2017-04-04

申请号：US14847191

申请日：2015-09-08

Applicant: LifeCuff Technologies Inc.

Inventor： Boris Leschinsky

IPC: A61K48/00 ,  C07H21/04 ,  C12N15/113 ,  A61K31/7088 ,  A61K45/06 ,  A61K31/00 ,  A61N5/06 ,  A61N5/10

CPC classification number: C12N15/113 ,  A61K31/00 ,  A61K31/7088 ,  A61K31/713 ,  A61K45/06 ,  A61N5/0613 ,  A61N5/10 ,  C12N2310/141 ,  C12N2320/30 ,  C12N2320/31

Abstract: Cancer treatment methods comprising a step of applying remote conditioning to the cancer subject, for example remote ischemic conditioning via several episodes of short-term limb occlusion. Upregulation and release of remote conditioning substances such as microRNA 144/451 cluster endogenously caused by remote conditioning may be beneficial in reducing the growth and proliferation of malignant cells. Remote conditioning may also be beneficial when combined with chemotherapy or radiation therapy as it may improve survival of healthy surrounding tissues and minimize side effects of these known cancer treatments. Remote conditioning may be non-invasively applied by a medical professional or self-applied by the cancer subject at home using an automatic device. The novel cancer treatment methods may be used for lung cancers, liver cancers, colorectal cancers, digestive cancers and other cancers.

公开(公告)号：US09950009B2

公开(公告)日：2018-04-24

申请号：US15431443

申请日：2017-02-13

Applicant: LifeCuff Technologies Inc.

Inventor： Boris Leschinsky

IPC: A61K35/14 ,  A61B17/132 ,  A61M1/02 ,  A61M1/34 ,  A61M1/36 ,  A61N1/36

CPC classification number: A61K35/14 ,  A61B17/1325 ,  A61M1/0259 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3406 ,  A61M1/36 ,  A61M1/3681 ,  A61M1/3687 ,  A61M1/3693 ,  A61M2205/3306 ,  A61M2205/3368 ,  A61N1/36

Abstract: Treatment methods are described using blood collected from a donor after subjecting thereof to remote conditioning such as remote ischemic conditioning via several episodes of short-term limb occlusion. Blood containing remote conditioning substances or a biologically active preparation containing such substances may be stored and used at a future time to afford a health benefit to the treatment subject. Extraction of remote conditioning substances may be done extracorporeally using dialysis or other blood processing methods following by returning of blood to the donor. Extraction of remote conditioning substances may be done during the time periods of their maximum presence in donor blood.

公开(公告)号：US20180049748A1

公开(公告)日：2018-02-22

申请号：US15798314

申请日：2017-10-30

Applicant: LifeCuff Technologies Inc.

Inventor： Boris Leschinsky

IPC: A61B17/135 ,  A61B5/022 ,  A61B5/0225 ,  A61B5/00 ,  A61B5/11

CPC classification number: A61B17/1355 ,  A61B5/0002 ,  A61B5/02225 ,  A61B5/02233 ,  A61B5/0225 ,  A61B5/1112

Abstract: Methods for adaptive cuff inflation for the purposes of occluding a limb of a subject include inflating a cuff to a pressure at or above limb occlusion pressure and periodically deflating the cuff to detect amplitude of oscillometric oscillations reaching or exceeding a predetermined threshold, whereby indicating that the cuff pressure has reached an updated systolic blood pressure. Selecting the cuff to be wide enough to define limb occlusion pressure at or below the systolic blood pressure assures that this maneuver does not compromise cessation of blood flow to the limb. Devices are disclosed configured to operate in at least two of the following three operating modes: a tourniquet mode, a remote conditioning mode and a blood pressure monitoring mode.

公开(公告)号：US11123256B1

公开(公告)日：2021-09-21

申请号：US17239627

申请日：2021-04-25

Applicant: LifeCuff Technologies Inc.

Inventor： Boris Leschinsky ,  Thomas A Moore ,  Abe Abramovich

IPC: A61H9/00 ,  A61B5/00 ,  G16H20/40

Abstract: A system for automated delivery and monitoring compliance for repeated remote ischemic conditioning treatments incudes at least one device for automated delivery of the therapy and at least one communications module to collect and record usage data. Reports of subject compliance with a predetermined schedule of therapy delivery is transmitted to the central database and a prescribing physician.

公开(公告)号：US20160068841A1

公开(公告)日：2016-03-10

申请号：US14847191

申请日：2015-09-08

Applicant: LifeCuff Technologies Inc.

Inventor： Boris Leschinsky

IPC: C12N15/113 ,  A61N5/10 ,  A61B17/12 ,  A61N5/06 ,  A61K31/7088 ,  A61K45/06

CPC classification number: C12N15/113 ,  A61K31/00 ,  A61K31/7088 ,  A61K31/713 ,  A61K45/06 ,  A61N5/0613 ,  A61N5/10 ,  C12N2310/141 ,  C12N2320/30 ,  C12N2320/31

Abstract: Cancer treatment methods comprising a step of applying remote conditioning to the cancer subject, for example remote ischemic conditioning via several episodes of short-term limb occlusion. Upregulation and release of remote conditioning substances such as microRNA 144/451 cluster endogenously caused by remote conditioning may be beneficial in reducing the growth and proliferation of malignant cells. Remote conditioning may also be beneficial when combined with chemotherapy or radiation therapy as it may improve survival of healthy surrounding tissues and minimize side effects of these known cancer treatments. Remote conditioning may be non-invasively applied by a medical professional or self-applied by the cancer subject at home using an automatic device. The novel cancer treatment methods may be used for lung cancers, liver cancers, colorectal cancers, digestive cancers and other cancers.

Abstract translation: 癌症治疗方法包括对癌症受试者进行远程调节的步骤，例如通过几次短期肢体闭塞的远端缺血调节。 通过远程调节内源性引起的远程调理物质如微RNA 144/451簇的上调和释放可能有益于减少恶性细胞的生长和增殖。 当与化疗或放射治疗相结合时，远程调理也可能是有益的，因为它可以改善健康的周围组织的存活并且最小化这些已知的癌症治疗的副作用。 远程调节可能由医疗专业人员非侵入式应用，也可能由家庭使用自动装置的癌症受试者自行应用。 新型癌症治疗方法可用于肺癌，肝癌，结肠直肠癌，消化性癌症等癌症。