公开(公告)号：US20140047572A1

公开(公告)日：2014-02-13

申请号：US13838111

申请日：2013-03-15

Applicant: Yuhchyau CHEN ,  J.H. David WU ,  Jane L. LIESVELD ,  Lin GAN

Inventor： Yuhchyau CHEN ,  J.H. David WU ,  Jane L. LIESVELD ,  Lin GAN

IPC: A61K31/4152 ,  G01N33/50 ,  A61K45/06

CPC classification number: A61K31/4152 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/196 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/715 ,  C07K16/2866 ,  G01N33/5008 ,  G01N33/5094 ,  G01N2333/524

Abstract: Disclosed are transgenic non-human mammals, which useful for the screening of thrombopoietin mimetics, thrombopoietin receptor agonists, or thrombopoietin receptor antagonists active on the human thrombopoietin receptor. The transgenic non-human mammal has a genome that comprises a stably integrated transgene construct comprising a polynucleotide sequence encoding a humanized thrombopoietin receptor wherein said transgenic non-human mammal has a baseline blood platelet count corresponding to a physiological blood platelet count of a matched non-transgenic non-human mammal. The chimeric thrombopoietin receptor comprises either the transmembrane domain of a human thrombopoietin receptor or both the extracellular and transmembrane domains of a human thrombopoietin receptor operably coupled to a cytoplasmic domain of a non-human thrombopoietin receptor.

公开(公告)号：US20120088666A1

公开(公告)日：2012-04-12

申请号：US13327724

申请日：2011-12-15

Applicant: Lin GAN

Inventor： Lin GAN

IPC: A01N59/14 ,  C05D1/00 ,  A01P1/00 ,  C05D9/00

CPC classification number: C05D9/02 ,  C01B35/1036 ,  C01B35/1045

Abstract: A method for preparing a boron fertilizer, including: (1) heating boric acid to a temperature of 180-200° C., maintaining the temperature for 20-30 min for dehydration of the boric acid to yield pyroboric acid; and (2) cooling down the pyroboric acid to a temperature of 40-60° C., crushing, and screening to yield a powdered, weakly acidic, high-content boron fertilizer. The method is energy-saving, environmentally friendly, and low in cost. The resulting boron fertilizer is weakly acidic, fast in dissolution rate, and has excellent in compounding performance

Abstract translation: 一种制备硼肥的方法，包括：（1）将硼酸加热至180-200℃，保持温度20-30分钟，使硼酸脱水得到焦硼酸; 和（2）将焦硼酸冷却至40-60℃的温度，进行粉碎和筛选以产生粉末状，弱酸性的高含量硼肥料。 该方法节能环保，成本低。 所得硼肥呈弱酸性，溶解速度快，复合性能优异