公开(公告)号：WO2015143363A1

公开(公告)日：2015-09-24

申请号：PCT/US2015/021819

申请日：2015-03-20

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： SEBASTIAN, Thomas ,  STEPHENS, Timothy

IPC: B01D45/08

CPC classification number: B01D45/08 ,  G01N1/40 ,  G01N1/4077 ,  G01N2015/0046

Abstract: A discrete bypass particle concentrator can significantly reduce surface fouling and manufacturing cost by including bypass stages after each of concentration stages. This invention provides a means of concentrating micron-scale particles, suspended in the ambient air or from a particulate feedstock, into a highly focused particle beam. It accomplishes this using a series of concentrating lens stages in parallel with bypass stages, reducing the overall flow Reynolds number of the particle beam. At the final stage, the diverted bypass flow forms an annular sheath flow around the particle beam, minimizing beam expansion.

Abstract translation: 离散旁路颗粒浓缩器可以通过在每个浓缩阶段之后包括旁路阶段来显着减少表面污染和制造成本。 本发明提供了将悬浮在环境空气中或从颗粒原料中的微米级颗粒聚集成高度聚焦的颗粒束的方法。 它使用一系列与旁路级并联的聚光透镜级来实现，从而减小了粒子束的总流量雷诺数。 在最后阶段，转向的旁路流在颗粒束周围形成环形护套流，使束的膨胀最小化。

公开(公告)号：WO2002066683A3

公开(公告)日：2002-08-29

申请号：PCT/US2002/003606

申请日：2002-02-06

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  HARPER, James, Douglas ,  MATHEWS, Richard, Hart ,  JOHNSON, Bernadette ,  PETROVICK, Martha, Susan ,  RUNDELL, Ann ,  NARGI, Frances, Ellen ,  STEPHENS, Timothy ,  MENDENHALL, Linda, Marie ,  HOLLIS, Mark, Alexander ,  YOUNG, Albert, M. ,  RIDER, Todd, Holman ,  SCHWOEBEL, Eric, David ,  VIAN, Trina, Rae

Inventor： HARPER, James, Douglas ,  MATHEWS, Richard, Hart ,  JOHNSON, Bernadette ,  PETROVICK, Martha, Susan ,  RUNDELL, Ann ,  NARGI, Frances, Ellen ,  STEPHENS, Timothy ,  MENDENHALL, Linda, Marie ,  HOLLIS, Mark, Alexander ,  YOUNG, Albert, M. ,  RIDER, Todd, Holman ,  SCHWOEBEL, Eric, David ,  VIAN, Trina, Rae

IPC: C12Q1/68

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles (Figure 4). The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.

公开(公告)号：EP1364070B1

公开(公告)日：2006-11-15

申请号：EP02726568.5

申请日：2002-02-06

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： HARPER, James, Douglas ,  MATHEWS, Richard, Hart ,  JOHNSON, Bernadette ,  PETROVICK, Martha, Susan ,  RUNDELL, Ann ,  NARGI, Frances, Ellen ,  STEPHENS, Timothy ,  MENDENHALL, Linda, Marie ,  HOLLIS, Mark, Alexander ,  YOUNG, Albert, M. ,  RIDER, Todd, Harrison ,  SCHWOEBEL, Eric, David ,  VIAN, Trina, Rae

IPC: G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  C12Q1/02 ,  C12Q1/24 ,  C12M1/34 ,  C12M1/28

CPC classification number: G01N33/554 ,  G01N15/0205 ,  G01N21/07 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/75 ,  G01N21/76 ,  G01N33/54373 ,  G01N33/54393 ,  G01N33/56983 ,  G01N33/582 ,  G01N2021/6439 ,  G01N2201/025 ,  G01N2201/061 ,  Y10S435/808 ,  Y10S436/805

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles (Figure 4). The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.

公开(公告)号：EP1364070A2

公开(公告)日：2003-11-26

申请号：EP02726568.5

申请日：2002-02-06

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： HARPER, James, Douglas ,  MATHEWS, Richard, Hart ,  JOHNSON, Bernadette ,  PETROVICK, Martha, Susan ,  RUNDELL, Ann ,  NARGI, Frances, Ellen ,  STEPHENS, Timothy ,  MENDENHALL, Linda, Marie ,  HOLLIS, Mark, Alexander ,  YOUNG, Albert, M. ,  RIDER, Todd, Harrison ,  SCHWOEBEL, Eric, David ,  VIAN, Trina, Rae

IPC: C12Q1/68 ,  G01N27/26 ,  G01N33/53 ,  G01N33/543 ,  G01N33/552 ,  G01N33/554 ,  H01L21/203 ,  H01L29/00

CPC classification number: G01N33/554 ,  G01N15/0205 ,  G01N21/07 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/75 ,  G01N21/76 ,  G01N33/54373 ,  G01N33/54393 ,  G01N33/56983 ,  G01N33/582 ,  G01N2021/6439 ,  G01N2201/025 ,  G01N2201/061 ,  Y10S435/808 ,  Y10S436/805

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles (Figure 4). The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.