公开(公告)号：CA2486173A1

公开(公告)日：2003-12-04

申请号：CA2486173

申请日：2003-05-22

Applicant: MEDTRONIC INC

Inventor： FERNANDES BRIAN C A ,  MORRIS MARY M ,  BERGAN MATTHEW A ,  GARDESKI KENNETH C ,  SPEAR STANTON C

IPC: C12N5/06 ,  A61K49/04 ,  A61K51/12 ,  A61L27/00 ,  A61L27/38 ,  A61L27/50 ,  C12N5/08

Abstract: A method involves selecting a type of cell for implantation into a mammal an d identifying the specific gravity or density of the cell type. Then, a carrie r liquid is selected which has a specific gravity or density within a range of specific gravities or densities which approximately matches the specific gravity or density of the selected cell type. A liquid for delivery of growt h cells into tissue of a mammal is also provided in which the density of a carrier fluid component is matched to the density of the cells being consistently delivered by the carrier fluid.

公开(公告)号：AT339226T

公开(公告)日：2006-10-15

申请号：AT03741809

申请日：2003-05-22

Applicant: MEDTRONIC INC

Inventor： MORRIS MARY M ,  FERNANDES BRIAN C A ,  SPEAR STANTON C ,  BERGAN MATTHEW A ,  GARDESKI KENNETH C

IPC: C12N5/06 ,  A61K49/04 ,  A61K51/12 ,  A61L27/00 ,  A61L27/38 ,  A61L27/50 ,  C12N5/08

Abstract: A method involves selecting a type of cell for implantation into a mammal and identifying the specific gravity or density of the cell type. Then, a carrier liquid is selected which has a specific gravity or density within a range of specific gravities or densities which approximately matches the specific gravity or density of the selected cell type. A liquid for delivery of growth cells into tissue of a mammal is also provided in which the density of a carrier fluid component is matched to the density of the cells being consistently delivered by the carrier fluid.

公开(公告)号：DE69333425D1

公开(公告)日：2004-04-01

申请号：DE69333425

申请日：1993-10-14

Applicant: MEDTRONIC INC

Inventor： JEVNE ALLAN H ,  BERGAN MATTHEW A ,  KEOGH JAMES R ,  HOBOT CHRISTOPHER M ,  EATON JOHN W

IPC: A61L27/00 ,  A61L27/54 ,  A61L29/00 ,  A61L29/16 ,  A61L31/00 ,  A61L33/00

Abstract: The invention relates to articles having bioactive agents coupled to or repelled by a graft polymer which is in turn bonded to a polymeric substrate surface. The articles are useful as thromboresistant and/or antimicrobial medical devices.

公开(公告)号：AU4975996A

公开(公告)日：1996-08-27

申请号：AU4975996

申请日：1996-02-08

Applicant: BERGAN MATTHEW A ,  MEDTRONIC INC ,  NELSON TIMOTHY S

Inventor： NELSON TIMOTHY S ,  BERGAN MATTHEW A

IPC: A61K9/00 ,  A61K9/22

Abstract: A device and method is disclosed for continuously administering an analgesic to the neuraxis of an organism. The device comprises a polymeric matrix body loaded with the analgesic. The body is implanted in the neuraxis where the analgesic diffuses into the neuraxis.

公开(公告)号：ES2271612T3

公开(公告)日：2007-04-16

申请号：ES03741809

申请日：2003-05-22

Applicant: MEDTRONIC INC

Inventor： MORRIS MARY M ,  FERNANDES BRIAN C A ,  SPEAR STANTON C ,  BERGAN MATTHEW A ,  GARDESKI KENNETH C

IPC: A61L27/38 ,  C12N5/06 ,  A61K49/04 ,  A61K51/12 ,  A61L27/00 ,  A61L27/50 ,  C12N5/08

Abstract: Un método para preparar una suspensión de líquido de vehículo de células para el implante en un mamífero, que comprende: a. seleccionar un tipo celular para el implante en un mamífero e identificar la densidad relativa del tipo celular; b. seleccionar un líquido de vehículo que tenga una densidad relativa en un intervalo de densidades relativas indicadas para coincidir aproximadamente con la densidad relativa del tipo celular seleccionado para producir una tasa de suministro de células aceptable en un destino de suministro en el mamífero; c. asegurar que el líquido identificado tiene una osmolalidad y pH apropiados para asegurar una viabilidad aceptable de las células en el destino de suministro; y d. mezclar el líquido de vehículo y las células en suspensión líquida.

公开(公告)号：AU2003273131A1

公开(公告)日：2003-12-12

申请号：AU2003273131

申请日：2003-05-22

Applicant: MEDTRONIC INC

Inventor： MORRIS MARY M ,  FERNANDES BRIAN C A ,  SPEAR STANTON C ,  BERGAN MATTHEW A ,  GARDESKI KENNETH C

IPC: C12N5/06 ,  A61K49/04 ,  A61K51/12 ,  A61L27/00 ,  A61L27/38 ,  A61L27/50 ,  C12N5/08

Abstract: A method involves selecting a type of cell for implantation into a mammal and identifying the specific gravity or density of the cell type. Then, a carrier liquid is selected which has a specific gravity or density within a range of specific gravities or densities which approximately matches the specific gravity or density of the selected cell type. A liquid for delivery of growth cells into tissue of a mammal is also provided in which the density of a carrier fluid component is matched to the density of the cells being consistently delivered by the carrier fluid.

公开(公告)号：CA2212165A1

公开(公告)日：1996-08-15

申请号：CA2212165

申请日：1996-02-08

Applicant: MEDTRONIC INC

Inventor： NELSON TIMOTHY S ,  BERGAN MATTHEW A

IPC: A61K9/00 ,  A61K9/22 ,  A61M37/00 ,  A61K45/08

Abstract: A device and method is disclosed for continuously administering an analgesic to the neuraxis of an organism. The device comprises a polymeric matrix body loaded with the analgesic. The body is implanted in the neuraxis where the analgesic diffuses into the neuraxis.

公开(公告)号：AU2003273131B2

公开(公告)日：2007-05-03

申请号：AU2003273131

申请日：2003-05-22

Applicant: MEDTRONIC INC

Inventor： MORRIS MARY M ,  FERNANDES BRIAN C A ,  SPEAR STANTON C ,  BERGAN MATTHEW A ,  GARDESKI KENNETH C

IPC: C12N5/06 ,  A61K49/04 ,  A61K51/12 ,  A61L27/00 ,  A61L27/38 ,  A61L27/50 ,  C12N5/08

Abstract: A method involves selecting a type of cell for implantation into a mammal and identifying the specific gravity or density of the cell type. Then, a carrier liquid is selected which has a specific gravity or density within a range of specific gravities or densities which approximately matches the specific gravity or density of the selected cell type. A liquid for delivery of growth cells into tissue of a mammal is also provided in which the density of a carrier fluid component is matched to the density of the cells being consistently delivered by the carrier fluid.

公开(公告)号：DE69333425T2

公开(公告)日：2004-12-02

申请号：DE69333425

申请日：1993-10-14

Applicant: MEDTRONIC INC

Inventor： JEVNE ALLAN H ,  BERGAN MATTHEW A ,  KEOGH JAMES R ,  HOBOT CHRISTOPHER M ,  EATON JOHN W

IPC: A61L27/00 ,  A61L27/54 ,  A61L29/00 ,  A61L29/16 ,  A61L31/00 ,  A61L33/00

Abstract: The invention relates to articles having bioactive agents coupled to or repelled by a graft polymer which is in turn bonded to a polymeric substrate surface. The articles are useful as thromboresistant and/or antimicrobial medical devices.

公开(公告)号：AU3121797A

公开(公告)日：1997-12-05

申请号：AU3121797

申请日：1997-05-12

Applicant: MEDTRONIC INC

Inventor： BERG ERIC P ,  WOLFF RODNEY G ,  LINDELL ELAINE P ,  TRESCONY PAUL V ,  BERGAN MATTHEW A ,  SCHWARTZ ROBERT S

IPC: A61F2/00 ,  A61F2/07 ,  A61F2/88 ,  A61F2/89 ,  B29C41/14 ,  B29C41/20 ,  A61F2/06

Abstract: Intraluminal stents and methods of manufacturing intraluminal stents are disclosed in which the stents have a plurality of recesses in the body of the stent, at least some of the recesses preferably providing a plurality of passageways between the inner and outer surfaces of the stent. The preferred stents are constructed of films on support structures having spaced apart elements, with the films having a thickness of between about 25 micrometers and about 400 micrometers. The stent can also be treated with an antithrombotic or a thrombolytic substance and, in some cases, the stents can incorporate therapeutic agents for delivery. The methods of manufacturing stents include forming the films using a solid particulate material that can be substantially removed after the film is formed, thereby forming the recesses and corresponding passageways described above. In preferred methods, the solid particulate material is soluble in a solvent in which the film is substantially insolvent.