公开(公告)号：WO1996032883A1

公开(公告)日：1996-10-24

申请号：PCT/US1996004547

申请日：1996-04-03

Applicant: MICROCOR, INC.

Inventor： MICROCOR, INC. ,  RUBEN, Paul, W. ,  KAMINSKY, Allan, L.

IPC: A61B05/02

CPC classification number: G01N33/49 ,  A61B5/14535 ,  A61B5/4869 ,  A61B5/7264

Abstract: This invention is a method and apparatus for non-invasiveness in determining hematocrit, utilizing the frequency dependent electrical impedance characteristics of whole blood by electrically stimulating a patient body portion containing a vascular compartment with a current source over a range of frequencies. A hematocrit measurement system includes a signal generator and demodulator [SGD] (34) that sends an applied signal to an electrode pod (36) that applies a current to a limb of a patient. The electrode pod (36) receives resulting measured voltage signals and provides them to the SGD. The SGD provides to a personal computer [PC] (42) signals indicative of the current passing through the limb of the patient and the resulting voltage. The voltage and current may be measured for various frequencies over, for example, a range from about 10 kHz to about 10 MHz. The electrical impedance from the blood alone is isolated from the total limb impedance from the blood, tissue, bone, etc. by determining the difference between measurement at different blood volumes. The hematocrit is determined by the PC based on inphase and quadrature data provided by the SGD. A neural network (52) may be useful in determining the hematocrit from the blood impedance patterns.

Abstract translation: 本发明是一种用于在确定血细胞比容方面非侵入性的方法和装置，利用全血的频率依赖性电阻抗特性，通过在一个频率范围内用电流源电流刺激包含血管隔室的患者体部分。 血细胞比容测量系统包括信号发生器和解调器（SGD）（34），其将施加的信号发送到向患者的肢体施加电流的电极盒（36）。 电极盒（36）接收得到的测量电压信号并将其提供给SGD。 SGD向个人计算机提供指示通过患者肢体的电流和所产生的电压的信号（42）。 可以在例如约10kHz至约10MHz的范围内针对各种频率测量电压和电流。 通过确定不同血容量的测量值之差，血液中单独血液的电阻抗与血液，组织，骨骼等的总肢体阻抗隔离。 基于由SGD提供的同相和正交数据由PC确定血细胞比容。 神经网络（52）可用于从血液阻抗模式确定血细胞比容。