公开(公告)号：JPS5757476B2

公开(公告)日：1982-12-04

申请号：JP1288479

申请日：1979-02-08

Applicant: MILES LAB

Inventor： ROBAATO NOOMAN SHUTSUTO ,  MAIKERU HOORU KOTEITSUKU ,  DEBITSUDO ROORENSU RERANDO ,  JOSEFU ODO HORATSUTSUI

IPC: A61K31/485 ,  A61P25/04 ,  A61P25/30 ,  C07D489/02

公开(公告)号：JPS62907B2

公开(公告)日：1987-01-10

申请号：JP1288379

申请日：1979-02-08

Applicant: MILES LAB

Inventor： MAIKERU HOORU KOTEITSUKU ,  ROBAATO NOOMAN SHUTSUTO ,  JOSEFU ODO HORATSUTSUI ,  DEBITSUDO ROORENSU RERANDO

IPC: A61K31/47 ,  A61P25/04 ,  C07D221/28 ,  C07D471/08 ,  C07D498/18

Abstract: Disclosed are 7-methyl, 8 beta -lower alkyl and 7 methyl-8-lower alkyl substituted B/C Cis or Trans morphinan-6-one compounds characterized by the structural formula: I Specific compounds, included within the scope of the foregoing general formula wherein R1 is H or methyl, R2 is cyclopropylmethyl or cyclobutylmethyl, R3 is H, methyl, ethyl or n-propyl and R4 is H or methyl are useful as mixed analgesics/narcotic antagonists.