公开(公告)号：JPH08107890A

公开(公告)日：1996-04-30

申请号：JP18158195

申请日：1995-07-18

Applicant: MINIMED INC

Inventor： JIYON BII SUREITO ,  PIITAA SHII ROODO

IPC: A61B10/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1486 ,  C12Q1/00 ,  G01N21/77 ,  A61B5/14

Abstract: PROBLEM TO BE SOLVED: To monitor the glucose concentration level in the blood of a patient continuously or with short intervals by including in the optrode means an oxygen sensitive coating on at least one optical fiber at a portion where optical signals are produced to indicate the oxygen deflation as a result of the enzymatic reaction. SOLUTION: When the sensor is in use, an enzyme coating 40 on an optrode 22 starts an enzymatic reaction and generates catalysis of glucose in the presence of oxygen to produce gluconic acid and hydrogen peroxide. The enzymatic reaction proceeds with a stoichiometric excess of oxygen. An oxygen sensitive coating 42 on the enzyme optrode 22 fluoresces at an activity level, i.e., a light level in proportion to the oxygen depletion as a result of the enzymatic reaction. An oxygen decrease is substantially in proportion to glucose concentration level, hence the oxygen decrease measurement can be directly related to glucose concentration level. Thus a miniature optical device for easy in vivo implantation is obtained.

公开(公告)号：JPH07275227A

公开(公告)日：1995-10-24

申请号：JP5558595

申请日：1995-03-15

Applicant: MINIMED INC

Inventor： PIITAA SHII ROODO ,  UIRIAMU PII BUAN ANTOWAAPU ,  JIYON JIEI MASUTOROTOTARO ,  POORU ESU CHIENII ZA SEKANDO ,  NANETSUTE EMU SHIYUNAABERU

IPC: G01N33/483 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1486 ,  A61B17/34 ,  A61M25/02 ,  G01N27/28 ,  G01N33/49 ,  A61B5/14

Abstract: PURPOSE: To provide a sensor insertion set suitable for setting promptly and easily a sensor of a patient in the condition where the sensor electrode is in direct contact with blood, etc., of the patient. CONSTITUTION: The insertion set 10 has an insertion needle 14 which extends by penetrating an attachment base 34 attached on the patient's skin. A flexible thin-membrane sensor is supported by the attachment base 34, and has proximal part which forms a conductive contact electrically connected to a monitor 32 and distal part 16 protruding from the attachment base 34 and having a sensor electrode 18. The proximal part and distal part 16 of the sensor are offset linearly, and when the attachment base is thrust upon the patient's skin, the distal part 16 is interfitted inside the insertion needle 14 for percutaneous setting of the sensor using said insertion needle 14. Then, the insertion needle 14 is pulled out, and the sensor distal part 16 is left in the specified insertion position in the condition where the sensor electrode 18 is in contact with blood, etc., of the patient.