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公开(公告)号：WO2014146005A9
公开(公告)日：2014-09-18
申请号：PCT/US2014/030874
申请日：2014-03-17
Applicant: MIRABILIS MEDICA, INC.
Inventor： DARLINGTON, Gregory Paul , ETCHELLS, Tim
Abstract: A method and system for adjusting a HIFU device compensates for shifts in transducer impedance so that the acoustic output from a HIFU transducer remains at a desired level. In accordance with a first aspect, the disclosure includes dynamically adjusting the tuning of a tuning network that causes the transducer/system to maintain an optimal power transfer to the acoustic output. In accordance with a second aspect, the disclosure monitors the acoustic output of the HIFU device and adjusts the electrical signal provided to the HIFU transducer to maintain a desired acoustic output.
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公开(公告)号：WO2014014965A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/050767
申请日：2013-07-16
Applicant: MIRABILIS MEDICA, INC.
Inventor： DUNBAR, Lee, David , PARSONS, Jessica, E. , PEDERSEN, Robert, H. , ETCHELLS, Tim , DARLINGTON, Gregory, Paul , LAU, Michael, P.H. , QUISTGAARD, Jens, Urich
CPC classification number: A61N7/00 , A61B34/25 , A61B2090/378 , A61N7/02
Abstract: A system and method for providing real-time, image-guided high intensity focused ultrasound (HIFU) targeting and treatment of tissue. In one embodiment, the system includes an HIFU applicator and a user interface with a touchscreen display for three-dimensional visualization of the tissue. Image frames displayed on the user interface depict real-time images of the tissue, including an image parallel to a feature of the applicator and an image orthogonal to the parallel image. Reference lines may be sketched using the touchscreen and displayed on the image frames. In one embodiment, tissue boundaries are detected and marked on the image frames, either by the user or automatically by the system. In another embodiment, the user interface includes a footswitch for the user to interact with the system. In another embodiment, the system includes an ultrasound imaging component configured to undock from the system for use as a stand-alone ultrasound imaging device.
Abstract translation: 一种用于提供实时，图像引导的高强度聚焦超声（HIFU）靶向和治疗组织的系统和方法。 在一个实施例中，系统包括HIFU施加器和具有触摸屏显示器的用户界面，用于组织的三维可视化。 显示在用户界面上的图像帧描绘了组织的实时图像，包括平行于施用器的特征的图像和与该平行图像正交的图像。 参考线可以使用触摸屏勾画并显示在图像帧上。 在一个实施例中，组织边界被检测和标记在图像帧上，无论是由用户还是由系统自动地标记。 在另一个实施例中，用户接口包括用于用户与系统交互的脚踏开关。 在另一个实施例中，该系统包括被配置为从该系统脱离以用作独立的超声成像装置的超声成像部件。
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公开(公告)号：WO2010048633A2
公开(公告)日：2010-04-29
申请号：PCT/US2009/062127
申请日：2009-10-26
Applicant: MIRABILIS MEDICA INC. , FRIEMEL, Barry , PARSONS, Jessica, E. , EMERY, Charles, D. , DARLINGTON, Gregory, P. , REED, Justin, A. , ETCHELLS, Tim
Inventor： FRIEMEL, Barry , PARSONS, Jessica, E. , EMERY, Charles, D. , DARLINGTON, Gregory, P. , REED, Justin, A. , ETCHELLS, Tim
CPC classification number: A61B8/08 , A61B17/42 , A61B2017/00119 , A61B2090/378 , A61N7/02
Abstract: HIFU therapy to a desired tissue site is controlled based on detected changes in one or more characteristics of a received backscatter signal resulting from exposure of the tissue to HIFU or other interrogation signals. In one embodiment, the bloom of backscatter signals outward from a treatment region (e.g., towards the HIFU transducer) is detected and monitored. Once the bloom reaches a predetermined location, treatment is stopped. Other signal characteristics such as angular distribution of frequency components in the backscatter signal, changes in reflection, power required to saturate a tissue characteristic, changes in attenuation and changes in a cumulative energy distribution function of the backscatter signal that change as a result of the application of HIFU power are also used to control the delivery of HIFU signals in accordance with other embodiments of the disclosed technology.
Abstract translation: 基于通过将组织暴露于HIFU或其他询问信号而导致的接收的反向散射信号的一个或多个特性的检测变化来控制对所需组织部位的HIFU治疗。 在一个实施例中，检测和监视来自处理区域（例如，朝向HIFU换能器）向外的反向散射信号的绽放。 一旦绽放到达预定位置，治疗就停止。 其他信号特性，例如反向散射信号中的频率分量的角度分布，反射变化，饱和组织特征所需的功率，衰减的变化以及作为应用的结果而改变的反向散射信号的累积能量分布函数的变化 的HIFU功率也用于根据所公开的技术的其他实施例来控制HIFU信号的传送。
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Patent Agency Ranking4.发明申请
公开(公告)号：WO2014146005A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/030874
申请日：2014-03-17
Applicant: MIRABILIS MEDICA, INC.
Inventor： DARLINGTON, Gregory Paul , ETCHELLS, Tim
CPC classification number: B06B1/0215 , B06B2201/40
Abstract: A method and system for adjusting a HIFU device compensates for shifts in transducer impedance so that the acoustic output from a HIFU transducer remains at a desired level. In accordance with a first aspect, the disclosure includes dynamically adjusting the tuning of a tuning network that causes the transducer/system to maintain an optimal power transfer to the acoustic output. In accordance with a second aspect, the disclosure monitors the acoustic output of the HIFU device and adjusts the electrical signal provided to the HIFU transducer to maintain a desired acoustic output.
Abstract translation: 用于调整HIFU装置的方法和系统补偿换能器阻抗的偏移，使得来自HIFU换能器的声输出保持在期望的水平。 根据第一方面，本公开包括动态地调整调谐网络的调谐，使调谐器/系统保持对声输出的最佳功率传递。 根据第二方面，本公开监测HIFU设备的声输出并调整提供给HIFU换能器的电信号以保持期望的声输出。
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公开(公告)号：EP2349482A2
公开(公告)日：2011-08-03
申请号：EP09822853.9
申请日：2009-10-26
Applicant: Mirabilis Medica Inc.
Inventor： FRIEMEL, Barry , PARSONS, Jessica, E. , EMERY, Charles, D. , DARLINGTON, Gregory, P. , REED, Justin, A. , ETCHELLS, Tim
CPC classification number: A61B8/08 , A61B17/42 , A61B2017/00119 , A61B2090/378 , A61N7/02
Abstract: HIFU therapy to a desired tissue site is controlled based on detected changes in one or more characteristics of a received backscatter signal resulting from exposure of the tissue to HIFU or other interrogation signals. In one embodiment, the bloom of backscatter signals outward from a treatment region (e.g., towards the HIFU transducer) is detected and monitored. Once the bloom reaches a predetermined location, treatment is stopped. Other signal characteristics such as angular distribution of frequency components in the backscatter signal, changes in reflection, power required to saturate a tissue characteristic, changes in attenuation and changes in a cumulative energy distribution function of the backscatter signal that change as a result of the application of HIFU power are also used to control the delivery of HIFU signals in accordance with other embodiments of the disclosed technology.
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公开(公告)号：EP2349482B1
公开(公告)日：2016-07-27
申请号：EP09822853.9
申请日：2009-10-26
Applicant: Mirabilis Medica Inc.
Inventor： FRIEMEL, Barry , PARSONS, Jessica, E. , EMERY, Charles, D. , DARLINGTON, Gregory, P. , REED, Justin, A. , ETCHELLS, Tim
CPC classification number: A61B8/08 , A61B17/42 , A61B2017/00119 , A61B2090/378 , A61N7/02
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公开(公告)号：EP2872044B1
公开(公告)日：2019-03-13
申请号：EP13819568.0
申请日：2013-07-16
Applicant: Mirabilis Medica, Inc.
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公开(公告)号：EP2872044A1
公开(公告)日：2015-05-20
申请号：EP13819568.0
申请日：2013-07-16
Applicant: Mirabilis Medica, Inc.
Inventor： DUNBAR, Lee, David , PARSONS, Jessica, E. , PEDERSEN, Robert, H. , ETCHELLS, Tim , DARLINGTON, Gregory, Paul , LAU, Michael, P.H. , QUISTGAARD, Jens, Urich
CPC classification number: A61N7/00 , A61B34/25 , A61B2090/378 , A61N7/02
Abstract: A system and method for providing real-time, image-guided high intensity focused ultrasound (HIFU) targeting and treatment of tissue. In one embodiment, the system includes an HIFU applicator and a user interface with a touchscreen display for three-dimensional visualization of the tissue. Image frames displayed on the user interface depict real-time images of the tissue, including an image parallel to a feature of the applicator and an image orthogonal to the parallel image. Reference lines may be sketched using the touchscreen and displayed on the image frames. In one embodiment, tissue boundaries are detected and marked on the image frames, either by the user or automatically by the system. In another embodiment, the user interface includes a footswitch for the user to interact with the system. In another embodiment, the system includes an ultrasound imaging component configured to undock from the system for use as a stand-alone ultrasound imaging device.
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