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公开(公告)号：ES2619176T3
公开(公告)日：2017-06-23
申请号：ES04773417
申请日：2004-09-17
Applicant: MITSUI CHEMICALS INC
Inventor： WADA MITSUFUMI , OIKAWA TOSHIHIRO , MOCHIZUKI DAISUKE , TOKUDA JUNKO , KAWASHIMA MIYUKI , ARAKI TADASHI , ABE REIKO , MIYAKE HITOKI , TAKAHASHI HITOSHI , SAWAI HIDEKI , MIMITSUKA TAKASHI , MORISHIGE TAKASHI , HIGASHI YOSUKE
Abstract: Un microorganismo recombinante en el que la actividad de D-lactato deshidrogenasa dependiente de FAD (did) inherente en el microorganismo recombinante esta inactivada o reducida, la actividad de piruvato formiato-liasa (pfl) esta inactivada o reducida y la actividad de D-lactato deshidrogenasa dependiente de NADH derivada de Escherichia coli (ldhA) esta potenciada.
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公开(公告)号：AU2010202683B2
公开(公告)日：2012-01-19
申请号：AU2010202683
申请日：2010-06-28
Applicant: MITSUI CHEMICALS INC
Inventor： BANBA SHINICHI , ITO KIYOSHI , KOBAYASHI HIDEKI , MATOISHI KAORI , OIKAWA TOSHIHIRO , TANAKA EISHI , YAMAKI TOSHIFUMI
Abstract: The amino acid sequence of a mutant which is obtained by introducing a novel mutation into a Pseudonocardia thermophila JCM3095-derived nitrile hydratase consisting of two types of heterogeneous subunits, and the base sequence of the gene are provided. The nitrile hydratase is modified by specifying the region to be modified in the stereostructure/amino acid sequence of the nitrile hydratase, and applying alteration such as substitution, insertion, deletion or the like, to the amino acids in the amino acid sequence which are corresponding to the amino acid residues forming the region. Also provided is a method for modifying an enzyme having a nitrile hydratase activity.
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公开(公告)号：DE602004016256D1
公开(公告)日：2008-10-16
申请号：DE602004016256
申请日：2004-07-08
Applicant: MITSUI CHEMICALS INC
Inventor： MIYAKE HITOKI , YAMAKI TOSHIFUMI , OIKAWA TOSHIHIRO , NAKAMURA TAKESHI , ISHIBASHI HIROKI , FUKUIRI YASUSHI , SAKUMA ATSUSHI , KOMATSU HIRONORI , ANDO TOMOYUKI , TOGASHI KAZUHIKO , UMETANI HIDEKI
Abstract: A novel gluconate dehydratase derived from Achromobacter xylosoxidans and a gene encoding the gluconate dehydratase are provided. By reacting the gluconate dehydratase or a transformed cell containing the gene with an aldonic acid, the corresponding 2-keto-3-deoxyaldonic acid can be efficiently produced.
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公开(公告)号：BRPI0414673A
公开(公告)日：2006-11-28
申请号：BRPI0414673
申请日：2004-09-17
Applicant: MITSUI CHEMICALS INC
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公开(公告)号：DE102004034228A1
公开(公告)日：2005-07-28
申请号：DE102004034228
申请日：2004-07-15
Applicant: MITSUI CHEMICALS INC
Inventor： ARAKI TADASHI , MIYAKE HITOKI , OIKAWA TOSHIHIRO
IPC: C12P19/40 , C07H17/02 , C07H19/067 , C07H19/073 , C07H19/06 , C12P19/38
Abstract: A method for producing a pyrimidine nucleoside compound includes reacting a sugar phosphate and pyrimidine base derivative using an enzyme having cytosine nucleoside phosphorylase activity, the pyrimidine base derivative being represented by general formula (I): (wherein R1 represents an amino group that may be replaced with an acyl group having an alkyl group of 1 to 3 carbon atoms or an alkyl group of 1 to 3 carbon atoms, an alkyl group of 1 to 3 carbon atoms, or a thiol group; R2 represents an amino group, a thiol group, a hydroxyl group, or a hydrogen atom; R3 represents an alkyl group of 1 to 3 carbon atoms that may be replaced with a hydroxyl group, an amino group, or a hydrogen atom; R4 represents a hydroxyl group or a hydrogen atom; when R1 is an amino group, when R2 is a hydroxyl group, and when R4 is a hydrogen atom; R3 is neither an alkyl group of 1 to 3 carbon atoms nor a hydrogen atom).
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Patent Agency Ranking
公开(公告)号：DE69828338D1
公开(公告)日：2005-02-03
申请号：DE69828338
申请日：1998-07-15
Applicant: MITSUI CHEMICALS INC
Inventor： OIKAWA TOSHIHIRO , FUKUHARA NOBUHIRO , MATSUBA YASUKO
Abstract: Optically active chroman-3-acetic acids and optically active chroman-3-acetic acid esters can be obtained by treating a mixture of (3R)- and (3S)-chroman-3-acetic esters of formula (I) Äwherein R1 is a straight or branched alkyl group having 1-5 carbon atoms and R2 is a hydrogen atom or substituted or unsubstituted amino groupÜ is treated with an esterase which has an optically selective hydrolyzing activity or microorganisms which carry said hydrolase, or a preparation therefrom. A novel esterase derived from bacteria of genus Pseudonocardia can also be used as said esterase.
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公开(公告)号：AU2003289338A1
公开(公告)日：2004-07-14
申请号：AU2003289338
申请日：2003-12-15
Applicant: MITSUI CHEMICALS INC
Inventor： ITO KIYOSHI , KOBAYASHI HIDEKI , TANAKA EISHI , OIKAWA TOSHIHIRO , YAMAKI TOSHIFUMI , BANBA SHINICHI , MATOISHI KAORI
Abstract: The present invention is aimed at providing the amino acid sequence of a nitrile hydratase having a novel mutation point, and the base sequence of the gene. It is also aimed at providing a method for modifying an enzyme having a nitrile hydratase activity. As a means to achieve the above objects, the amino acid sequence of a mutant which is obtained by introducing a novel mutation into a Pseudonocardia thermophila JCM3095-derived nitrile hydratase consisting of two types of heterogeneous subunits, and the base sequence of the gene are provided. Further, the nitrile hydratase is modified by specifying the region to be modified in the stereostructure/amino acid sequence of the nitrile hydratase, and applying alteration such as substitution, insertion, deletion or the like, to the amino acids in the amino acid sequence which are corresponding to the amino acid residues forming the region. According to the invention, it is possible to convert a nitrile compound to a corresponding amide compound more efficiently compared with the prior art.
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公开(公告)号：DE60227595D1
公开(公告)日：2008-08-28
申请号：DE60227595
申请日：2002-05-01
Applicant: MITSUI CHEMICALS INC
Inventor： ARAKI TADASHI , IKEDA ICHIROU , MATOISHI KAORI , ABE REIKO , OIKAWA TOSHIHIRO , MATSUBA YASUKO , ISHIBASHI HIROKI , NAGAHARA KIYOTERU , FUKUIRI YASUSHI
Abstract: The invention provides a method for producing a cytosine nucleoside compound from pentose-1-phosphate and cytosine or a derivative thereof using a nucleoside phosphorylase reactive to cytosine or a bacterium having the enzyme activity. The invention also provides a method for specifically reducing an activity to degrade the substrates or the product, resulting in efficient production of the cytosine nucleoside compound. According to the invention, little by-product is produced in producing cytonucleocide compounds.
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公开(公告)号：DE69828338T2
公开(公告)日：2005-06-02
申请号：DE69828338
申请日：1998-07-15
Applicant: MITSUI CHEMICALS INC
Inventor： OIKAWA TOSHIHIRO , FUKUHARA NOBUHIRO , MATSUBA YASUKO
Abstract: Optically active chroman-3-acetic acids and optically active chroman-3-acetic acid esters can be obtained by treating a mixture of (3R)- and (3S)-chroman-3-acetic esters of formula (I) Äwherein R1 is a straight or branched alkyl group having 1-5 carbon atoms and R2 is a hydrogen atom or substituted or unsubstituted amino groupÜ is treated with an esterase which has an optically selective hydrolyzing activity or microorganisms which carry said hydrolase, or a preparation therefrom. A novel esterase derived from bacteria of genus Pseudonocardia can also be used as said esterase.
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公开(公告)号：CA2380804A1
公开(公告)日：2002-11-01
申请号：CA2380804
申请日：2002-04-30
Applicant: MITSUI CHEMICALS INC
Inventor： IKEDA ICHIROU , FUKUIRI YASUSHI , ISHIBASHI HIROKI , ABE REIKO , MATOISHI KAORI , OIKAWA TOSHIHIRO , ARAKI TADASHI , MATSUBA YASUKO , NAGAHARA KIYOTERU
Abstract: The invention provides a method for producing a cytosine nucleoside compound from pentose-1-phosphate and cytosine or a derivative thereof using a nucleoside phosphorylase reactive to cytosine or a bacterium having the enzyme activity. The invention also provides a method for specifically reducing an activity to degrade the substrates or the product, resulting in efficient production of the cytosine nucleoside compound. According to the invention, little by-product is produced in producing cytonucleocide compounds.
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