公开(公告)号：BR0203343A

公开(公告)日：2003-06-10

申请号：BR0203343

申请日：2002-05-02

Applicant: MITSUI CHEMICALS INC

Inventor： ARAKI TADASHI ,  IKEDA ICHIROU ,  MATOISHI KAORI ,  ABE REIKO ,  OIKAWA TOSHIRO ,  MATSUBA YASUKO ,  ISHIBASHI HIROKI ,  NAGAHARA KIYOTERU ,  FUKUIRI YASUSHI

IPC: C12N1/21 ,  C12N9/10 ,  C12N15/54 ,  C12P19/38

Abstract: The invention provides a method for producing a cytosine nucleoside compound from pentose-1-phosphate and cytosine or a derivative thereof using a nucleoside phosphorylase reactive to cytosine or a bacterium having the enzyme activity. The invention also provides a method for specifically reducing an activity to degrade the substrates or the product, resulting in efficient production of the cytosine nucleoside compound. According to the invention, little by-product is produced in producing cytonucleocide compounds.