公开(公告)号：EP0666253A4

公开(公告)日：1996-04-10

申请号：EP93923036

申请日：1993-10-20

Applicant: TAISHO PHARMA CO LTD ,  MITSUI PETROCHEMICAL IND

Inventor： MIYOSHI TOSHIO ,  ASAMI YUMIKO ,  SATO MASAKAZU ,  ISHIGURO MASAHARU ,  KITAHARA TAKUMI ,  TOMINO IKUO

IPC: C07C317/36 ,  C07C323/37 ,  C07C323/41 ,  A61K31/135 ,  A61K31/14 ,  A61K31/16 ,  C07C317/40

CPC classification number: C07C323/37 ,  C07C317/36 ,  C07C323/41

Abstract: An N-t-butylaniline analog represented by general formula (I) or a salt thereof, and a lipid level depressant containing the same as the active ingredient. In said formula, R and R , which may be the same or different from each other, represent each hydrogen, halogen, amino, nitro, acetamide, lower alkyl, lower alkoxy, halogenated lower alkyl, halogenated lower alkoxy or lower alkanoyl; R represents hydrogen, halogen, lower alkoxy or halogenated lower alkyl; and Z represents S, SO or SO2. This compound has a remarkably excellent effect of depressing the lipid level as compared with clofibrate and 4-(N-t-butyl)methanesulfonylaminodiphenyl ether and is extremely reduced in toxicity.

公开(公告)号：EP0424525A4

公开(公告)日：1990-09-05

申请号：EP89900305

申请日：1988-12-09

Applicant: MITSUI PETROCHEMICAL IND ,  MITSUI PHARMACEUTICALS

Inventor： TOMINO IKUO ,  ISHIGURO MASAHARU ,  KITAHARA TAKUMI ,  YOKOYAMA KEIICHI ,  KIHARA NORIAKI ,  KAMIYA JOJI ,  YOSHIHARA KANJI ,  ISHII MASAAKI ,  MIZUCHI AKIRA ,  HORIKOMI KAZUTOSHI ,  AWAYA AKIRA ,  NAKANO TAKUO

IPC: A61K31/34 ,  A61K31/35 ,  C07C217/18 ,  C07C217/22 ,  C07C217/32 ,  C07D209/08 ,  C07D209/48 ,  C07D211/14 ,  C07D215/04 ,  C07D217/02 ,  C07D217/24 ,  C07D235/06 ,  C07D265/36 ,  C07D307/78 ,  C07D307/79 ,  C07D307/80 ,  C07D307/83 ,  C07D307/86 ,  C07D307/91 ,  C07D311/04 ,  C07D311/08 ,  C07D311/14 ,  C07D311/16 ,  C07D311/18 ,  C07D311/20 ,  C07D311/22 ,  C07D311/24 ,  C07D311/58 ,  C07D311/74 ,  C07D317/06 ,  C07D317/46 ,  C07D317/48 ,  C07D327/04 ,  C07D401/12 ,  C07D405/12 ,  C07D407/12 ,  C07D471/10 ,  C07D487/04 ,  C07D487/22 ,  C07D491/10

CPC classification number: C07D209/48 ,  C07C217/18 ,  C07C217/22 ,  C07C217/32 ,  C07C2602/08 ,  C07D209/08 ,  C07D211/14 ,  C07D215/04 ,  C07D217/02 ,  C07D217/24 ,  C07D235/06 ,  C07D265/36 ,  C07D307/78 ,  C07D307/79 ,  C07D307/80 ,  C07D307/83 ,  C07D307/86 ,  C07D307/91 ,  C07D311/04 ,  C07D311/14 ,  C07D311/16 ,  C07D311/18 ,  C07D311/20 ,  C07D311/22 ,  C07D311/24 ,  C07D311/58 ,  C07D317/46 ,  C07D317/48 ,  C07D327/04 ,  C07D401/12 ,  C07D405/12 ,  C07D407/12 ,  C07D471/10 ,  C07D487/04 ,  C07D491/10

Abstract: Amines represented by general formula (1) and acid addition salts and quaternary ammonium salts thereof are disclosed. The amines represented by formula (1) or pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof are useful for treatment and prophylaxis of heart diseases of animals, particularly arrhythmia, myocardial infarction, angina pectoris, cardiac failure, etc.

Abstract translation: 公开了由通式（1）表示的胺及其酸加成盐和季铵盐。 由式（1）表示的胺或其药学上可接受的酸加成盐和季铵盐可用于治疗和预防动物心脏病，特别是心律失常，心肌梗死，心绞痛，心力衰竭等。

公开(公告)号：CA2020232C

公开(公告)日：1996-11-19

申请号：CA2020232

申请日：1990-06-29

Applicant: MITSUI PETROCHEMICAL IND

Inventor： FUKUOKA DAISUKE ,  ISHITOKU TAKESHI ,  TAKAHASHI KATSUYA ,  TASHIRO TAKASHI ,  IMUTA JUNICHI ,  TAN HIROAKI ,  ISHIGURO MASAHARU ,  KIHARA NORIAKI ,  MUKAIYAMA TERUAKI

IPC: C07D311/20 ,  C07D311/58

Abstract: Process for preparing polyalkyl-2-alkoxy-7-hydroxychroman derivative of the general formula(V): (V) wherein R1 denotes lower primary alkyl, R2 denotes hydrogen or lower primary alkyl and R3 denotes loweralkyl, by reacting resorcin with either an aliphatic ketone of the general formula(I): (I) wherein R1 and R2 are as defined above, and an alcohol of the formula(II): R3OH (II) wherein R3 is as defined above, in the presence of an acid catalyst, or an aliphatic ketone acetal of the general formula(III): (III) wherein R1, R2 and R3 are as defined above, in the presence of an acid catalyst.

公开(公告)号：DE3852551D1

公开(公告)日：1995-02-02

申请号：DE3852551

申请日：1988-12-09

Applicant: MITSUI PETROCHEMICAL IND ,  MITSUI PHARMACEUTICALS

Inventor： TOMINO IKUO ,  ISHIGURO MASAHARU ,  KITAHARA TAKUMI ,  YOKOYAMA KEIICHI ,  KIHARA NORIAKI ,  KAMIYA JOJI ,  YOSHIHARA KANJI ,  ISHII MASAAKI ,  MIZUCHI AKIRA ,  HORIKOMI KAZUTOSHI ,  AWAYA AKIRA ,  NAKANO TAKUO

IPC: A61K31/34 ,  A61K31/35 ,  C07C217/18 ,  C07C217/22 ,  C07C217/32 ,  C07D209/08 ,  C07D209/48 ,  C07D211/14 ,  C07D215/04 ,  C07D217/02 ,  C07D217/24 ,  C07D235/06 ,  C07D265/36 ,  C07D307/78 ,  C07D307/79 ,  C07D307/80 ,  C07D307/83 ,  C07D307/86 ,  C07D307/91 ,  C07D311/04 ,  C07D311/08 ,  C07D311/14 ,  C07D311/16 ,  C07D311/18 ,  C07D311/20 ,  C07D311/22 ,  C07D311/24 ,  C07D311/58 ,  C07D311/74 ,  C07D317/06 ,  C07D317/46 ,  C07D317/48 ,  C07D327/04 ,  C07D401/12 ,  C07D405/12 ,  C07D407/12 ,  C07D471/10 ,  C07D487/04 ,  C07D487/22 ,  C07D491/10

Abstract: Amines represented by general formula (1) and acid addition salts and quaternary ammonium salts thereof are disclosed. The amines represented by formula (1) or pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof are useful for treatment and prophylaxis of heart diseases of animals, particularly arrhythmia, myocardial infarction, angina pectoris, cardiac failure, etc.

公开(公告)号：HUT54134A

公开(公告)日：1991-01-28

申请号：HU407390

申请日：1990-07-03

Applicant: MITSUI PETROCHEMICAL IND

Inventor： FUKUOKA DAISUKE ,  ISHITOKU TAKESHI ,  TAKAHASHI KATSUYA ,  TASHIRO TAKASHI ,  IMUTA JUNICHI ,  TAN HIROAKI ,  ISHIGURO MASAHARU ,  KIHARA NORIAKI ,  MUKAIYAMA TERUAKI

IPC: C07D311/20 ,  C07D311/16

Abstract: Process for preparing polyalkyl-2-alkoxy-7-hydroxychroman derivative of the general formula (V) :wherein R¹ denotes C₁ -C₄ primary alkyl, R² denotes hydrogen or C₁ -C₄ primary alkyl and R³ denotes C₁-C₄ alkyl, by reacting resorcin with   an aliphatic ketone acetal of the general formula (III):wherein R¹ , R² and R³ are as defined above, in the presence of an acid catalyst.

公开(公告)号：DE3854675D1

公开(公告)日：1995-12-14

申请号：DE3854675

申请日：1988-09-08

Applicant: MITSUI PETROCHEMICAL IND

Inventor： ISHIGURO MASAHARU ,  MIKI HISAYA ,  HIROKANE NOBUYA

IPC: C07C37/08 ,  C07C39/14 ,  C07C409/08 ,  C07C409/12

Abstract: A method of oxidizing secondary alkyl substituted naphthalenes with molecular oxygen in a liquid phase to hydroperoxides, carbinols or mixtures of these, which comprises: oxidizing the secondary alkyl substituted naphthalenes in the presence of an aromatic hydrocarbon having a fused ring which contains at least one methylene group therein in amounts of not more than about 1000 ppm based on the secondary alkyl substituted naphthalene used. A process of producing isopropylnaphthols is also disclosed, which comprises: oxidizing diisopropylnaphthalenes with molecular oxygen in a liquid phase to diisopropylnaphthalene monohydroperoxides in the presence of (a) either an aromatic hydrocarbon having a fused ring which contains at least one methylene group therein, or a paladium catalyst soluble in the reaction mixture, and (b) an organic polar compound such as acetonitrile; and then acid-decomposing the diisopropylnaphthalene monohydroperoxide to the isopropylnaphthol.

公开(公告)号：DE3852551T2

公开(公告)日：1995-05-18

申请号：DE3852551

申请日：1988-12-09

Applicant: MITSUI PETROCHEMICAL IND ,  MITSUI PHARMACEUTICALS

Inventor： TOMINO IKUO ,  ISHIGURO MASAHARU ,  KITAHARA TAKUMI ,  YOKOYAMA KEIICHI ,  KIHARA NORIAKI ,  KAMIYA JOJI ,  YOSHIHARA KANJI ,  ISHII MASAAKI ,  MIZUCHI AKIRA ,  HORIKOMI KAZUTOSHI ,  AWAYA AKIRA ,  NAKANO TAKUO

IPC: A61K31/34 ,  A61K31/35 ,  C07C217/18 ,  C07C217/22 ,  C07C217/32 ,  C07D209/08 ,  C07D209/48 ,  C07D211/14 ,  C07D215/04 ,  C07D217/02 ,  C07D217/24 ,  C07D235/06 ,  C07D265/36 ,  C07D307/78 ,  C07D307/79 ,  C07D307/80 ,  C07D307/83 ,  C07D307/86 ,  C07D307/91 ,  C07D311/04 ,  C07D311/08 ,  C07D311/14 ,  C07D311/16 ,  C07D311/18 ,  C07D311/20 ,  C07D311/22 ,  C07D311/24 ,  C07D311/58 ,  C07D311/74 ,  C07D317/06 ,  C07D317/46 ,  C07D317/48 ,  C07D327/04 ,  C07D401/12 ,  C07D405/12 ,  C07D407/12 ,  C07D471/10 ,  C07D487/04 ,  C07D487/22 ,  C07D491/10

Abstract: Amines represented by general formula (1) and acid addition salts and quaternary ammonium salts thereof are disclosed. The amines represented by formula (1) or pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof are useful for treatment and prophylaxis of heart diseases of animals, particularly arrhythmia, myocardial infarction, angina pectoris, cardiac failure, etc.

公开(公告)号：CA2147495A1

公开(公告)日：1994-04-28

申请号：CA2147495

申请日：1993-10-20

Applicant: TAISHO PHARMA CO LTD ,  MITSUI PETROCHEMICAL IND

Inventor： MIYOSHI TOSHIO ,  ASAMI YUMIKO ,  SATO MASAKAZU ,  ISHIGURO MASAHARU ,  KITAHARA TAKUMI ,  TOMINO IKUO

IPC: C07C317/36 ,  C07C323/37 ,  C07C323/41 ,  A61K31/135 ,  A61K31/16 ,  C07C317/34

Abstract: The invention relates to N-t-butylaniline analog represented by formula (I): ( I ) wherein R1 and R2 are the same or different and represent a hydrogen atom, halogen atom, amino group, nitro group, acetamido group, lower alkyl group, lower alkoxy group, halogeno lower alkyl group, halogeno lower alkoxy group or lower alkanoyl group, R3 represents a hydrogen atom, halogen atom, lower alkoxy group or halogeno lower alkyl group, and Z represents S, SO or SO2, as well as a salt thereof. A lipid level depressant containing the same is also claimed. The compound of the invention has a remarkable effect of depressing the lipid level as compared with clofibrate and 4-(N-t-butyl)methanesulfonylaminodiphenyl ether and is extremely low toxicity. 28

公开(公告)号：DE3874061D1

公开(公告)日：1992-10-01

申请号：DE3874061

申请日：1988-09-08

Applicant: MITSUI PETROCHEMICAL IND

Inventor： ISHIGURO MASAHARU ,  MIKI HISAYA ,  HIROKANE NOBUYA

IPC: C07C37/08 ,  C07C39/14 ,  C07C409/08 ,  C07C409/12 ,  C07C409/04

Abstract: A method of oxidizing secondary alkyl substituted naphthalenes with molecular oxygen in a liquid phase to hydroperoxides, carbinols or mixtures of these, which comprises: oxidizing the secondary alkyl substituted naphthalenes in the presence of an aromatic hydrocarbon having a fused ring which contains at least one methylene group therein in amounts of not more than about 1000 ppm based on the secondary alkyl substituted naphthalene used. A process of producing isopropylnaphthols is also disclosed, which comprises: oxidizing diisopropylnaphthalenes with molecular oxygen in a liquid phase to diisopropylnaphthalene monohydroperoxides in the presence of (a) either an aromatic hydrocarbon having a fused ring which contains at least one methylene group therein, or a paladium catalyst soluble in the reaction mixture, and (b) an organic polar compound such as acetonitrile; and then acid-decomposing the diisopropylnaphthalene monohydroperoxide to the isopropylnaphthol.

公开(公告)号：DE69120221T2

公开(公告)日：1996-11-21

申请号：DE69120221

申请日：1991-07-03

Applicant: MITSUI PETROCHEMICAL IND ,  MITSUI PHARMACEUTICALS

Inventor： MIZUCHI AKIRA ,  IKEDA KEN ,  KOKUBUN YUICHIRO ,  HORIKOMI KAZUTOSHI ,  SASAKI TADAYUKI ,  AWAYA AKIRA ,  TOMINO IKUO ,  ISHIGURO MASAHARU ,  KITAHARA TAKUMI ,  KIHARA NORIAKI

IPC: C07D239/48 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  A61K31/505 ,  C07D403/14

Abstract: A pyrimidine compound represented by general formula (I), pharmaceutically acceptable salts thereof, and a drug containing the same for treating neural diseases, wherein X represents substituted or cyclic amino and Y represents substituted amino or substituted carbonyl. These compounds have activities of promoting the growth of nerve cells and the formation and extension of neurites, so that they are useful in treating various neural diseases.