公开(公告)号：EP0424525A4

公开(公告)日：1990-09-05

申请号：EP89900305

申请日：1988-12-09

Applicant: MITSUI PETROCHEMICAL IND ,  MITSUI PHARMACEUTICALS

Inventor： TOMINO IKUO ,  ISHIGURO MASAHARU ,  KITAHARA TAKUMI ,  YOKOYAMA KEIICHI ,  KIHARA NORIAKI ,  KAMIYA JOJI ,  YOSHIHARA KANJI ,  ISHII MASAAKI ,  MIZUCHI AKIRA ,  HORIKOMI KAZUTOSHI ,  AWAYA AKIRA ,  NAKANO TAKUO

IPC: A61K31/34 ,  A61K31/35 ,  C07C217/18 ,  C07C217/22 ,  C07C217/32 ,  C07D209/08 ,  C07D209/48 ,  C07D211/14 ,  C07D215/04 ,  C07D217/02 ,  C07D217/24 ,  C07D235/06 ,  C07D265/36 ,  C07D307/78 ,  C07D307/79 ,  C07D307/80 ,  C07D307/83 ,  C07D307/86 ,  C07D307/91 ,  C07D311/04 ,  C07D311/08 ,  C07D311/14 ,  C07D311/16 ,  C07D311/18 ,  C07D311/20 ,  C07D311/22 ,  C07D311/24 ,  C07D311/58 ,  C07D311/74 ,  C07D317/06 ,  C07D317/46 ,  C07D317/48 ,  C07D327/04 ,  C07D401/12 ,  C07D405/12 ,  C07D407/12 ,  C07D471/10 ,  C07D487/04 ,  C07D487/22 ,  C07D491/10

CPC classification number: C07D209/48 ,  C07C217/18 ,  C07C217/22 ,  C07C217/32 ,  C07C2602/08 ,  C07D209/08 ,  C07D211/14 ,  C07D215/04 ,  C07D217/02 ,  C07D217/24 ,  C07D235/06 ,  C07D265/36 ,  C07D307/78 ,  C07D307/79 ,  C07D307/80 ,  C07D307/83 ,  C07D307/86 ,  C07D307/91 ,  C07D311/04 ,  C07D311/14 ,  C07D311/16 ,  C07D311/18 ,  C07D311/20 ,  C07D311/22 ,  C07D311/24 ,  C07D311/58 ,  C07D317/46 ,  C07D317/48 ,  C07D327/04 ,  C07D401/12 ,  C07D405/12 ,  C07D407/12 ,  C07D471/10 ,  C07D487/04 ,  C07D491/10

Abstract: Amines represented by general formula (1) and acid addition salts and quaternary ammonium salts thereof are disclosed. The amines represented by formula (1) or pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof are useful for treatment and prophylaxis of heart diseases of animals, particularly arrhythmia, myocardial infarction, angina pectoris, cardiac failure, etc.

Abstract translation: 公开了由通式（1）表示的胺及其酸加成盐和季铵盐。 由式（1）表示的胺或其药学上可接受的酸加成盐和季铵盐可用于治疗和预防动物心脏病，特别是心律失常，心肌梗死，心绞痛，心力衰竭等。

公开(公告)号：EP0666253A4

公开(公告)日：1996-04-10

申请号：EP93923036

申请日：1993-10-20

Applicant: TAISHO PHARMA CO LTD ,  MITSUI PETROCHEMICAL IND

Inventor： MIYOSHI TOSHIO ,  ASAMI YUMIKO ,  SATO MASAKAZU ,  ISHIGURO MASAHARU ,  KITAHARA TAKUMI ,  TOMINO IKUO

IPC: C07C317/36 ,  C07C323/37 ,  C07C323/41 ,  A61K31/135 ,  A61K31/14 ,  A61K31/16 ,  C07C317/40

CPC classification number: C07C323/37 ,  C07C317/36 ,  C07C323/41

Abstract: An N-t-butylaniline analog represented by general formula (I) or a salt thereof, and a lipid level depressant containing the same as the active ingredient. In said formula, R and R , which may be the same or different from each other, represent each hydrogen, halogen, amino, nitro, acetamide, lower alkyl, lower alkoxy, halogenated lower alkyl, halogenated lower alkoxy or lower alkanoyl; R represents hydrogen, halogen, lower alkoxy or halogenated lower alkyl; and Z represents S, SO or SO2. This compound has a remarkably excellent effect of depressing the lipid level as compared with clofibrate and 4-(N-t-butyl)methanesulfonylaminodiphenyl ether and is extremely reduced in toxicity.

公开(公告)号：EP0192783A4

公开(公告)日：1987-03-26

申请号：EP85904492

申请日：1985-09-07

Applicant: MITSUI PETROCHEMICAL IND

Inventor： YOKOYAMA KEIICHI ,  ISHIDA TATSUYOSHI ,  ISAYAMA SHIGERU ,  KATO KOHJI ,  KITAHARA TAKUMI ,  FURUYA YOSHIAKI

IPC: A01N43/60 ,  A01N43/90 ,  C07D239/84 ,  C07D471/04 ,  C07D487/04 ,  C07D239/70

CPC classification number: C07D471/04 ,  A01N43/60 ,  A01N43/90 ,  C07D239/84 ,  C07D487/04

Abstract: Novel 2-piperazinopyrimidine derivatives represented by following general formula (I), wherein R1 represents H or aralkyl; Y represents one of the following groups (II) to (VII), (wherein a and b represent positions to be bound to positions 4 and 5 of the pyrimidine ring, respectively, l1 and l2 each represents an integer of 2 to 4, l3 represents 2 or 0 and l4 represents 0 or 1, provided that l4 is 0 when l3 is 2, and l4 is 1 when l3 is 0, l5 represents 2 or 3, l6 represents 1 or 2, l7 represents 2 or 3, R2 represents OH or toluenesulfonyloxy, and R3, R4, R5, R6, and R7 each represents H or a lower alkyl). These compounds are useful as, for example, effective ingredients of herbicides.

Abstract translation: 由以下通式（I）表示的新型2-哌嗪基嘧啶衍生物，其中R1代表H或芳烷基; Y代表下列基团（II）至（VII）之一，（其中a和b分别表示与嘧啶环的4位和5位结合的位置，l1和l2各自代表2至4的整数，l3 代表2或0，并且l4代表0或1，条件是当l3是2时l4是0，当l3是0时l4是1，l5代表2或3，l6代表1或2，l7代表2或3，R2代表 OH或甲苯磺酰氧基，且R 3，R 4，R 5，R 6和R 7各自表示H或低级烷基）。 这些化合物可用作例如除草剂的有效成分。

公开(公告)号：DE3752141T2

公开(公告)日：1998-03-26

申请号：DE3752141

申请日：1987-02-24

Applicant: MITSUI PETROCHEMICAL IND ,  MITSUI PHARMACEUTICALS

Inventor： AWAYA AKIRA ,  NAKANO TAKUO ,  KOBAYASHI HISASHI ,  TAN KEN-EI ,  HORIKOMI KAZUTOSHI ,  SASAKI TADAYUKI ,  YOKOYAMA KEIICHI ,  OHNO HIROYASU ,  KATO KOZI ,  KITAHARA TAKUMI ,  TOMINO IKUO ,  ISAYAMA SHIGERU

IPC: A61K31/505 ,  A61K31/506 ,  C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/70 ,  C07D239/84 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  A61K31/55

Abstract: Agents contain as active component a cpd. of formula (I) or its salts. In (I) R1 is H, 2-4C acyl, 2-5C alkoxycarbonyl, 3-5C alkoxycarbonylmethyl, bezyl, 3-4-dimethoxybenzoyl or 3,4-methylenedioxybenzyl; R2 is H, amino, mono(1-4C alkyl)amino, 1-5C alkoxy or 2-4C alkoxycarbonyl; R3 is H, 2-4C alkoxycarbonyl, dialkylaminocarbonyl (contg. 1-9C alkyl groups), 1-5C alkoxy or hydroxyethyl; or R2/R3 together may complete a 4-7C carbocyclic or heterocyclic (contg. N, O or S) Ring; R4 is H, 1-4C alkyl or 1-4C alkylthio.

公开(公告)号：DE3752141D1

公开(公告)日：1998-01-02

申请号：DE3752141

申请日：1987-02-24

Applicant: MITSUI PETROCHEMICAL IND ,  MITSUI PHARMACEUTICALS

Inventor： AWAYA AKIRA ,  NAKANO TAKUO ,  KOBAYASHI HISASHI ,  TAN KEN-EI ,  HORIKOMI KAZUTOSHI ,  SASAKI TADAYUKI ,  YOKOYAMA KEIICHI ,  OHNO HIROYASU ,  KATO KOZI ,  KITAHARA TAKUMI ,  TOMINO IKUO ,  ISAYAMA SHIGERU

IPC: A61K31/505 ,  A61K31/506 ,  C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/70 ,  C07D239/84 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  A61K31/55

Abstract: Agents contain as active component a cpd. of formula (I) or its salts. In (I) R1 is H, 2-4C acyl, 2-5C alkoxycarbonyl, 3-5C alkoxycarbonylmethyl, bezyl, 3-4-dimethoxybenzoyl or 3,4-methylenedioxybenzyl; R2 is H, amino, mono(1-4C alkyl)amino, 1-5C alkoxy or 2-4C alkoxycarbonyl; R3 is H, 2-4C alkoxycarbonyl, dialkylaminocarbonyl (contg. 1-9C alkyl groups), 1-5C alkoxy or hydroxyethyl; or R2/R3 together may complete a 4-7C carbocyclic or heterocyclic (contg. N, O or S) Ring; R4 is H, 1-4C alkyl or 1-4C alkylthio.

公开(公告)号：DE3852551T2

公开(公告)日：1995-05-18

申请号：DE3852551

申请日：1988-12-09

Applicant: MITSUI PETROCHEMICAL IND ,  MITSUI PHARMACEUTICALS

Inventor： TOMINO IKUO ,  ISHIGURO MASAHARU ,  KITAHARA TAKUMI ,  YOKOYAMA KEIICHI ,  KIHARA NORIAKI ,  KAMIYA JOJI ,  YOSHIHARA KANJI ,  ISHII MASAAKI ,  MIZUCHI AKIRA ,  HORIKOMI KAZUTOSHI ,  AWAYA AKIRA ,  NAKANO TAKUO

IPC: A61K31/34 ,  A61K31/35 ,  C07C217/18 ,  C07C217/22 ,  C07C217/32 ,  C07D209/08 ,  C07D209/48 ,  C07D211/14 ,  C07D215/04 ,  C07D217/02 ,  C07D217/24 ,  C07D235/06 ,  C07D265/36 ,  C07D307/78 ,  C07D307/79 ,  C07D307/80 ,  C07D307/83 ,  C07D307/86 ,  C07D307/91 ,  C07D311/04 ,  C07D311/08 ,  C07D311/14 ,  C07D311/16 ,  C07D311/18 ,  C07D311/20 ,  C07D311/22 ,  C07D311/24 ,  C07D311/58 ,  C07D311/74 ,  C07D317/06 ,  C07D317/46 ,  C07D317/48 ,  C07D327/04 ,  C07D401/12 ,  C07D405/12 ,  C07D407/12 ,  C07D471/10 ,  C07D487/04 ,  C07D487/22 ,  C07D491/10

Abstract: Amines represented by general formula (1) and acid addition salts and quaternary ammonium salts thereof are disclosed. The amines represented by formula (1) or pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof are useful for treatment and prophylaxis of heart diseases of animals, particularly arrhythmia, myocardial infarction, angina pectoris, cardiac failure, etc.

公开(公告)号：HU209574B

公开(公告)日：1994-08-29

申请号：HU148892

申请日：1989-12-22

Applicant: MITSUI PETROCHEMICAL IND ,  MITSUI PHARMACEUTICALS

Inventor： AWAYA AKIRA ,  TAKESUE MITSUYUKI ,  KITAHARA TAKUMI ,  HORIKOMI KAZUTOSHI ,  SASAKI TADAYUKI ,  MIZUCHI AKIRA ,  KIHARA NORIAKI ,  TOMINO IKUO

IPC: A61K31/445 ,  A61K31/505 ,  C07D239/42 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D487/04

公开(公告)号：CA2147495A1

公开(公告)日：1994-04-28

申请号：CA2147495

申请日：1993-10-20

Applicant: TAISHO PHARMA CO LTD ,  MITSUI PETROCHEMICAL IND

Inventor： MIYOSHI TOSHIO ,  ASAMI YUMIKO ,  SATO MASAKAZU ,  ISHIGURO MASAHARU ,  KITAHARA TAKUMI ,  TOMINO IKUO

IPC: C07C317/36 ,  C07C323/37 ,  C07C323/41 ,  A61K31/135 ,  A61K31/16 ,  C07C317/34

Abstract: The invention relates to N-t-butylaniline analog represented by formula (I): ( I ) wherein R1 and R2 are the same or different and represent a hydrogen atom, halogen atom, amino group, nitro group, acetamido group, lower alkyl group, lower alkoxy group, halogeno lower alkyl group, halogeno lower alkoxy group or lower alkanoyl group, R3 represents a hydrogen atom, halogen atom, lower alkoxy group or halogeno lower alkyl group, and Z represents S, SO or SO2, as well as a salt thereof. A lipid level depressant containing the same is also claimed. The compound of the invention has a remarkable effect of depressing the lipid level as compared with clofibrate and 4-(N-t-butyl)methanesulfonylaminodiphenyl ether and is extremely low toxicity. 28

公开(公告)号：HU9201485D0

公开(公告)日：1992-07-28

申请号：HU148592

申请日：1989-12-22

Applicant: MITSUI PHARMACEUTICALS ,  MITSUI PETROCHEMICAL IND

Inventor： TOMINO IKUO ,  TAKESUE MITSUYUKI ,  KIHARA NORIAKI ,  KITAHARA TAKUMI ,  AWAYA AKIRA ,  HORIKOMI KAZUTOSHI ,  SASAKI TADAYUKI ,  MIZUCHI AKIRA

IPC: A61K31/445 ,  A61K31/505 ,  C07D239/42 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D487/04

公开(公告)号：HU896762D0

公开(公告)日：1990-03-28

申请号：HU676289

申请日：1989-12-22

Applicant: MITSUI PETROCHEMICAL IND

Inventor： TOMINO IKUO ,  TAKESUE MITSUYUKI ,  KIHARA NORIAKI ,  KITAHARA TAKUMI ,  AWAYA AKIRA ,  HORIKOMI KAZUTOSHI ,  SASAKI TADAYUKI ,  MIZUCHI AKIRA

IPC: A61K31/505 ,  C07D213/75 ,  C07D239/28 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D453/02 ,  C07D471/08 ,  C07D487/04

Abstract: 2-Substituted pyrrelo[2,3-d]pyrimidines are useful for the treatment of neurological diseases.