公开(公告)号：CA2018978A1

公开(公告)日：1990-12-22

申请号：CA2018978

申请日：1990-06-14

Applicant: MITSUI PETROCHEMICAL IND

Inventor： ORI AIICHIRO ,  IMUTA JUNICHI ,  KIHARA NORIAKI

IPC: A61K31/415 ,  A61P27/02 ,  A61P27/06 ,  C07D405/06

Abstract: Process for preparing imidazole derivatives of the general formula (II) : wherein R and R independently are loweralkyl, by desulfurizing a mercaptoimidazole derivative of the general formula (I) : wherein R and R are as defined above, with nitric acid optionally in the presence of a nitrite. The compounds of the formula (II) are useful for the treatment of glaucoma.

公开(公告)号：HU210053B

公开(公告)日：1995-01-30

申请号：HU395390

申请日：1990-06-22

Applicant: MITSUI PETROCHEMICAL IND

Inventor： KIHARA NORIAKI ,  IMUTA JUNICHI ,  ORI AIICHIRO

IPC: A61K31/415 ,  A61P27/02 ,  A61P27/06 ,  C07D405/06

Abstract: Process for preparing imidazole derivatives of the general formula (II) : wherein R and R independently are loweralkyl, by desulfurizing a mercaptoimidazole derivative of the general formula (I) : wherein R and R are as defined above, with nitric acid optionally in the presence of a nitrite. The compounds of the formula (II) are useful for the treatment of glaucoma.

公开(公告)号：DE69008431D1

公开(公告)日：1994-06-01

申请号：DE69008431

申请日：1990-06-22

Applicant: MITSUI PETROCHEMICAL IND

Inventor： ORI AIICHIRO ,  IMUTA JUNICHI ,  KIHARA NORIAKI C O MITSUI PETR

IPC: A61K31/415 ,  A61P27/02 ,  A61P27/06 ,  C07D405/06

Abstract: Process for preparing imidazole derivatives of the general formula (II) : wherein R and R independently are loweralkyl, by desulfurizing a mercaptoimidazole derivative of the general formula (I) : wherein R and R are as defined above, with nitric acid optionally in the presence of a nitrite. The compounds of the formula (II) are useful for the treatment of glaucoma.

公开(公告)号：AT104975T

公开(公告)日：1994-05-15

申请号：AT90111875

申请日：1990-06-22

Applicant: MITSUI PETROCHEMICAL IND

Inventor： ORI AIICHIRO ,  IMUTA JUNICHI ,  KIHARA NORIAKI

IPC: A61K31/415 ,  A61P27/02 ,  A61P27/06 ,  C07D405/06

Abstract: Process for preparing imidazole derivatives of the general formula (II) : wherein R and R independently are loweralkyl, by desulfurizing a mercaptoimidazole derivative of the general formula (I) : wherein R and R are as defined above, with nitric acid optionally in the presence of a nitrite. The compounds of the formula (II) are useful for the treatment of glaucoma.

公开(公告)号：DE69018576T2

公开(公告)日：1995-08-17

申请号：DE69018576

申请日：1990-11-21

Applicant: MITSUI PETROCHEMICAL IND

Inventor： KISE SHOICHI ,  HAYASHIDA MIKIO ,  ORI AIICHIRO ,  HIRATSUKA JUNZOU ,  YAMADA HIDEAKI

IPC: C12P17/04 ,  C12P41/00 ,  C12R1/01 ,  C12R1/06 ,  C12R1/07 ,  C12R1/13 ,  C12R1/19 ,  C12R1/20 ,  C12R1/32 ,  C12R1/365 ,  C12R1/385 ,  C12R1/425 ,  C12R1/64 ,  C12R1/645 ,  C12R1/66 ,  C12R1/72 ,  C12R1/845

Abstract: A process for preparing (+)-homopilopic acid and the salts thereof which comprises hydrolyzing a mixture of (+)-homopilopic acid ester of the general formula (I): wherein R1 denotes a straight or branched C1-C10 hydrocarbon, and (-)-homopilopic acid ester of the general formula (II): wherein R2 denotes a straight or branched C1-C10 hydrocarbon, in the presence of a culture, cells, culture supernatant or treated matter of a microorganism belonging to the genus Arthrobacter, Aspergillus, Escherichia, Cunninghamella, Xanthomonas, Candida, Pseudomonas, Serratia, Cellulomonas, Nocardia, Bacillus, Brevibacterium, Flavobacterium, Mycobacterium, Rhizomucor, Rhodotorula or Rhodococcus.

公开(公告)号：HU205096B

公开(公告)日：1992-03-30

申请号：HU152891

申请日：1991-05-07

Applicant: MITSUI PETROCHEMICAL IND

Inventor： IMUTA JUNICHI ,  ORI AIICHIRO ,  KIHARA NORIAKI

IPC: C07D307/33

Abstract: The present invention provides a process for preparing dihydrofuranone derivative of the fornula (III): wherein R and R are individually lower alkyl, and R is hydrogen or lower alkyl, by reacting a dihydrofuranone derivative of the formula (I): wherein R is as defined above, with a malonic acid derivative of the formula (II): wherein R and R are as defined above, in the presence of an alkalimetal alkoxide and/or an alkalimetal hydroxide.

公开(公告)号：HUT57757A

公开(公告)日：1991-12-30

申请号：HU152891

申请日：1991-05-07

Applicant: MITSUI PETROCHEMICAL IND

Inventor： IMUTA JUNICHI ,  ORI AIICHIRO ,  KIHARA NORIAKI

IPC: C07D307/33

Abstract: The present invention provides a process for preparing dihydrofuranone derivative of the fornula (III): wherein R and R are individually lower alkyl, and R is hydrogen or lower alkyl, by reacting a dihydrofuranone derivative of the formula (I): wherein R is as defined above, with a malonic acid derivative of the formula (II): wherein R and R are as defined above, in the presence of an alkalimetal alkoxide and/or an alkalimetal hydroxide.

公开(公告)号：CA2030218A1

公开(公告)日：1991-05-23

申请号：CA2030218

申请日：1990-11-19

Applicant: MITSUI PETROCHEMICAL IND

Inventor： KISE SHOICHI ,  HAYASHIDA MIKIO ,  ORI AIICHIRO ,  HIRATSUKA JUNZOU ,  YAMADA HIDEAKI

IPC: C12P17/04 ,  C12P41/00 ,  C12R1/01 ,  C12R1/06 ,  C12R1/07 ,  C12R1/13 ,  C12R1/19 ,  C12R1/20 ,  C12R1/32 ,  C12R1/365 ,  C12R1/385 ,  C12R1/425 ,  C12R1/64 ,  C12R1/645 ,  C12R1/66 ,  C12R1/72 ,  C12R1/845

Abstract: A process for preparing (+)-homopilopic acid and the salts thereof which comprises hydrolyzing a mixture of (+)-homopilopic acid ester of the general formula (I): wherein R1 denotes a straight or branched C1-C10 hydrocarbon, and (-)-homopilopic acid ester of the general formula (II): wherein R2 denotes a straight or branched C1-C10 hydrocarbon, in the presence of a culture, cells, culture supernatant or treated matter of a microorganism belonging to the genus Arthrobacter, Aspergillus, Escherichia, Cunninghamella, Xanthomonas, Candida, Pseudomonas, Serratia, Cellulomonas, Nocardia, Bacillus, Brevibacterium, Flavobacterium, Mycobacterium, Rhizomucor, Rhodotorula or Rhodococcus.

公开(公告)号：DE69018576D1

公开(公告)日：1995-05-18

申请号：DE69018576

申请日：1990-11-21

Applicant: MITSUI PETROCHEMICAL IND

Inventor： KISE SHOICHI ,  HAYASHIDA MIKIO ,  ORI AIICHIRO ,  HIRATSUKA JUNZOU ,  YAMADA HIDEAKI

IPC: C12P17/04 ,  C12P41/00 ,  C12R1/01 ,  C12R1/06 ,  C12R1/07 ,  C12R1/13 ,  C12R1/19 ,  C12R1/20 ,  C12R1/32 ,  C12R1/365 ,  C12R1/385 ,  C12R1/425 ,  C12R1/64 ,  C12R1/645 ,  C12R1/66 ,  C12R1/72 ,  C12R1/845

Abstract: A process for preparing (+)-homopilopic acid and the salts thereof which comprises hydrolyzing a mixture of (+)-homopilopic acid ester of the general formula (I): wherein R1 denotes a straight or branched C1-C10 hydrocarbon, and (-)-homopilopic acid ester of the general formula (II): wherein R2 denotes a straight or branched C1-C10 hydrocarbon, in the presence of a culture, cells, culture supernatant or treated matter of a microorganism belonging to the genus Arthrobacter, Aspergillus, Escherichia, Cunninghamella, Xanthomonas, Candida, Pseudomonas, Serratia, Cellulomonas, Nocardia, Bacillus, Brevibacterium, Flavobacterium, Mycobacterium, Rhizomucor, Rhodotorula or Rhodococcus.

公开(公告)号：DE69008431T2

公开(公告)日：1994-09-29

申请号：DE69008431

申请日：1990-06-22

Applicant: MITSUI PETROCHEMICAL IND

Inventor： ORI AIICHIRO ,  IMUTA JUNICHI ,  KIHARA NORIAKI C O MITSUI PETR

IPC: A61K31/415 ,  A61P27/02 ,  A61P27/06 ,  C07D405/06

Abstract: Process for preparing imidazole derivatives of the general formula (II) : wherein R and R independently are loweralkyl, by desulfurizing a mercaptoimidazole derivative of the general formula (I) : wherein R and R are as defined above, with nitric acid optionally in the presence of a nitrite. The compounds of the formula (II) are useful for the treatment of glaucoma.