公开(公告)号：EP1238114A2

公开(公告)日：2002-09-11

申请号：EP00993326.8

申请日：2000-12-11

Applicant: MOTOROLA, INC.

Inventor： CHOONG, Vi-En ,  GALLAGHER, Sean ,  GASKIN, Mike ,  LI, Changming ,  MARACAS, George ,  SHI, Song

IPC: C12Q1/68 ,  G01N27/00

CPC classification number: G01N33/5438 ,  C12Q1/6825

Abstract: This invention relates to the detection of molecular interactions between biological molecules. Specifically, the invention relates to electrical detection of interactions such as hybridization between nucleic acids or peptide antigen-antibody interactions using arrays of peptides or oligonucleotides. In particular, the invention relates to an apparatus and methods for detecting nucleic acid hybridization or peptide binding using electronic methods including AC impedance. In some embodiments, no electrochemical or other label moieties are used. In others, electrochemically active labels are used to detect reactions on hydrogel arrays, including genotyping reactions such as the single base extension reaction.

公开(公告)号：EP1190253A1

公开(公告)日：2002-03-27

申请号：EP00939709.2

申请日：2000-06-09

Applicant: MOTOROLA, INC.

Inventor： LI, Changming ,  SHI, Song ,  CHOONG, Vi-En ,  MARACAS, George

IPC: G01N33/543 ,  C12Q1/68

CPC classification number: G01N33/5438 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00614 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00713 ,  B01J2219/0072 ,  C12Q1/6825 ,  C12Q2565/607

Abstract: This invention encompasses charge neutral conjugated polymer or copolymers which have a functional group for binding a biomolecule probe; electrodes and array of electrodes in electrical contact with such polymers and wherein a biomolecule probe is covalently lined to the polymer. The invention includes biosensors which utilize the conjugated polymer coated electrodes wherein the binding to the biomolecule probe is detected by electrical means such as AC impedance.

公开(公告)号：WO1998026463A1

公开(公告)日：1998-06-18

申请号：PCT/US1997022176

申请日：1997-11-26

Applicant: MOTOROLA INC.

Inventor： MOTOROLA INC. ,  WU, Han ,  LI, Changming ,  LIAN, Ke, Keryn

IPC: H01M06/14

CPC classification number: H01M6/181

Abstract: An electrolyte (15) for an electrochemical cell is provided. The electrolyte (15) is an admixture of H3PO4 and a high temperature polymer such as poly(benzimidazole) in ratios between 2:1 and 50:1. Fumed silica is added to the electrolyte (15) at levels between 0.2 % and 8 % by weight. An electrochemical cell is fabricated using the electrolyte (15), and exhibits improved adhesion between the electrolyte (15) and the electrode (13).

Abstract translation: 提供了一种用于电化学电池的电解质（15）。 电解质（15）是H 2 PO 4与比例为2:1至50:1之间的聚（苯并咪唑）的高温聚合物的混合物。 将煅制二氧化硅以0.2重量％至8重量％的含量加入到电解质（15）中。 使用电解质（15）制造电化学电池，并且显示出电解质（15）和电极（13）之间的改善的粘合性。

公开(公告)号：WO1998025282A1

公开(公告)日：1998-06-11

申请号：PCT/US1997021838

申请日：1997-11-26

Applicant: MOTOROLA INC.

Inventor： MOTOROLA INC. ,  LI, Changming ,  JUNG, Richard, H. ,  NERZ, John

IPC: H01G09/00

CPC classification number: H01G9/155 ,  Y02E60/13 ,  Y10T29/417

Abstract: An electrochemical capacitor cell (140) is provided with electrodes (146, 148, 150 and 152) solid polymer electrolytes (154, 156 and 158) and first and second metallic foil collectors (142, 144). The electrodes may either be of the same or different materials and may be fabricated from ruthenium, iridium, cobalt, tungsten, vanadium, iron, molybdenum, hafnium, nickel, silver, zinc, and combinations thereof. The solid polymer electrolyte is in intimate contact with the electrodes, and is made from a polymeric support structure having dispersed therein an electrolytic active species.

Abstract translation: 电化学电容器电池（140）设置有固体聚合物电解质（154,156和158）和第一和第二金属箔收集器（142,144）的电极（146,148,150和152）。 电极可以是相同或不同的材料，并且可以由钌，铱，钴，钨，钒，铁，钼，铪，镍，银，锌及其组合制成。 固体聚合物电解质与电极紧密接触，并由其中分散有电解活性物质的聚合物支持结构制成。

公开(公告)号：WO1997038460A1

公开(公告)日：1997-10-16

申请号：PCT/US1997005904

申请日：1997-04-08

Applicant: MOTOROLA INC.

Inventor： MOTOROLA INC. ,  LI, Changming ,  LIAN, Ke, Keryn ,  ESCHBACH, Florence, O.

IPC: H01M06/18

CPC classification number: H01G9/025 ,  H01M10/052 ,  H01M10/0565

Abstract: An electrochemical cell (10) is provided with first (20) and second (30) electrodes, and a solid polymer electrolyte (40) disposed therebetween. The electrodes may either be of the same or different materials and may be fabricated from ruthenium, iridium, cobalt, tungsten, vanadium, iron, molybdenum, nickel, silver, zinc, and combinations thereof. The solid polymer electrolyte is in intimate contact with both the anode and the cathode, and is made from a polymeric support structure having dispersed therein an electrolyte active species. The polymer support structure is preferably a polybenzimidazole.

Abstract translation: 电化学电池（10）设置有第一电极（20）和第二电极（30），以及设置在其间的固体聚合物电解质（40）。 电极可以是相同或不同的材料，并且可以由钌，铱，钴，钨，钒，铁，钼，镍，银，锌及其组合制成。 固体聚合物电解质与阳极和阴极紧密接触，并且由其中分散有电解质活性物质的聚合物支撑结构制成。 聚合物载体结构优选为聚苯并咪唑。

公开(公告)号：WO1996031912A1

公开(公告)日：1996-10-10

申请号：PCT/US1996004551

申请日：1996-04-03

Applicant: MOTOROLA INC.

Inventor： MOTOROLA INC. ,  LI, Changming ,  BAI, Lijun ,  LIAN, Keryn, Ke

IPC: H01M04/58

CPC classification number: H01G9/155 ,  H01G11/32 ,  H01M4/60 ,  H01M4/663 ,  Y02E60/13

Abstract: An electrode for an energy storage device is made from an activated carbon support. The activated carbon has adsorbed onto it a protonated polymer, which has a polyoxometalate absorbed into the polymer. Preferably, the protonated polymer is poly(4-vinylpyridine), and the polyoxometalate is isopolymolybdate. An energy storage device, such as a capacitor, can be made from the modified carbon electrode. A pair of the coated carbon electrodes (13) are placed in contact with an electrolyte to form the device.

Abstract translation: 用于储能装置的电极由活性炭载体制成。 活性炭吸附在其上被质子化的聚合物，其具有吸收到聚合物中的多金属氧酸盐。 优选地，质子化聚合物是聚（4-乙烯基吡啶），多金属氧酸盐是异多钼酸盐。 诸如电容器的能量存储装置可以由改性碳电极制成。 将一对涂覆的碳电极（13）放置成与电解质接触以形成该装置。

公开(公告)号：WO2002031463A2

公开(公告)日：2002-04-18

申请号：PCT/US2001/027282

申请日：2001-08-31

Applicant: MOTOROLA, INC.

Inventor： LI, Changming

IPC: G01N

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00713 ,  B01L3/5085 ,  C40B60/14 ,  G01N33/5438

Abstract: This invention relates to the dectection of biomolecules. Specifically, the invention relates to electronic or electrochemical detection of biomolecules using biochip arrays. In particular, the invention provides an apparatus comprising a platform for a column-and-row addressable, high-density, enhanced-sensitivity biochip array, and mehtods of use thereof. The devices and methods of the invention can be used to detect molecular interactions such as nucleic acid hybridization or protein binding.

Abstract translation: 本发明涉及生物分子的检测。 具体地，本发明涉及使用生物芯片阵列的生物分子的电子或电化学检测。 特别地，本发明提供了一种装置，其包括用于列和行可寻址，高密度，增强灵敏度的生物芯片阵列的平台及其使用方法。 本发明的装置和方法可用于检测分子相互作用，例如核酸杂交或蛋白质结合。

公开(公告)号：WO1998026466A1

公开(公告)日：1998-06-18

申请号：PCT/US1997022175

申请日：1997-11-26

Applicant: MOTOROLA INC.

Inventor： MOTOROLA INC. ,  LI, Changming

IPC: H01M10/34

CPC classification number: H01M10/052 ,  H01M6/181 ,  H01M10/0565 ,  H01M2300/0082

Abstract: An electrochemical cell is provided with first (10) and second (11) electrodes and a solid polymer electrolyte (15) disposed therebetween. The solid polymer electrolyte is preferably fabricated by providing a polybenzimidazole polymeric material which is subjected to a sulfur containing acidic species, at temperatures sufficient to sulfonate the polybenzimidazole. Electrochemical cells fabricated using these devices demonstrate performance characteristics far better than those available in the prior art.

Abstract translation: 电化学电池设置有第一电极（10）和第二电极（11），以及设置在其间的固体聚合物电解质（15）。 优选通过在足以使聚苯并咪唑磺化的温度下提供经受含硫酸性物质的聚苯并咪唑聚合物材料来制备固体聚合物电解质。 使用这些装置制造的电化学电池表现出比现有技术中可用的性能特征更好的性能特征。

公开(公告)号：WO2001061053A3

公开(公告)日：2001-08-23

申请号：PCT/US2001/005476

申请日：2001-02-20

Applicant: MOTOROLA, INC. ,  LI, Changming ,  SAWYER, Jaymie, Robin ,  CHOONG, Vi-En ,  MARACAS, George ,  ZHANG, Peiming

Inventor： LI, Changming ,  SAWYER, Jaymie, Robin ,  CHOONG, Vi-En ,  MARACAS, George ,  ZHANG, Peiming

IPC: G01N33/543

Abstract: The present invention provides an apparatus and methods for the electrical detection of molecular interactions between a probe molecule and a protein or peptide target molecule, but without requiring the use of electrochemical or other reporters to obtain measurable signals. The methods can be used for electrical detection of molecular interactions between probe molecules bound to defined regions of an array and protein or peptide target molecules which are permitted to interact with the probe molecules.

公开(公告)号：WO1998004008A1

公开(公告)日：1998-01-29

申请号：PCT/US1997012369

申请日：1997-07-21

Applicant: MOTOROLA INC.

Inventor： MOTOROLA INC. ,  LI, Changming ,  LIAN, Ke, Keryn ,  JUNG, Richard, H.

IPC: H01M02/16

CPC classification number: H01G9/025 ,  H01G11/54 ,  H01M6/181 ,  H01M6/22 ,  H01M8/0289 ,  H01M8/1025 ,  H01M8/103 ,  H01M8/1048 ,  H01M8/1069 ,  H01M10/02 ,  H01M10/10 ,  Y02E60/13 ,  Y02P70/56 ,  Y10T29/49115

Abstract: An electrochemical cell is provided with first (10) and second (11) electrodes and a solid polymer electrolyte (15) disposed therebetween. The solid polymer electrolyte is preferably fabricated by providing a linear powdered polymeric precursor material which is thereafter heated to temperatures sufficient to drive off moisture and in the presence of an electrolyte active species. The electrolyte active species is preferably an acidic electrolyte active species which has the effect of protonating the powdered polymeric precursor material. Electrochemical cells fabricated using these devices demonstrate performance characteristics far better than those available in the prior art.

Abstract translation: 电化学电池设置有第一电极（10）和第二电极（11），以及设置在其间的固体聚合物电解质（15）。 固体聚合物电解质优选通过提供线性粉末状聚合物前体材料制造，然后将其加热至足以驱除水分并在电解质活性物质存在下的温度。 电解质活性物质优选是酸性电解质活性物质，其具有质子化粉末状聚合物前体材料的作用。 使用这些装置制造的电化学电池表现出比现有技术中可用的性能特征更好的性能特征。