公开(公告)号：EP1750129A2

公开(公告)日：2007-02-07

申请号：EP06022907.7

申请日：2002-02-06

Applicant: Massachusetts Institute of Technology

Inventor： Harper, James Douglas ,  Mathews, Richard Hart ,  Johnson, Bernadette ,  Petrovick, Martha Susan ,  Rundell, Ann ,  Nargi, Frances Ellen ,  Stephens, Timothy ,  Mendenhall, Linda Marie ,  Hollis, Mark Alexander ,  Young, Albert M. ,  Rider, Todd Holman ,  Schwoebel, Eric David ,  Vian, Trina Rae

IPC: G01N33/50

CPC classification number: G01N33/554 ,  G01N15/0205 ,  G01N21/07 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/75 ,  G01N21/76 ,  G01N33/54373 ,  G01N33/54393 ,  G01N33/56983 ,  G01N33/582 ,  G01N2021/6439 ,  G01N2201/025 ,  G01N2201/061 ,  Y10S435/808 ,  Y10S436/805

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.

Abstract translation: 本发明涉及用于检测一种或多种目标颗粒（例如细菌和抗原）的光电子系统。 该系统包括反应室，样品收集器，光学检测器和含有电池的储存器，每个电池具有存在于每个电池表面上并且对待检测的靶颗粒是特异性的受体，其中结合 受体的目标颗粒直接或间接激活报告分子，例如水母发光蛋白或indo-1，从而产生可测量的光学信号。

公开(公告)号：EP1750129A3

公开(公告)日：2007-07-18

申请号：EP06022907.7

申请日：2002-02-06

Applicant: Massachusetts Institute of Technology

Inventor： Harper, James Douglas ,  Mathews, Richard Hart ,  Johnson, Bernadette ,  Petrovick, Martha Susan ,  Rundell, Ann ,  Nargi, Frances Ellen ,  Stephens, Timothy ,  Mendenhall, Linda Marie ,  Hollis, Mark Alexander ,  Young, Albert M. ,  Rider, Todd Holman ,  Schwoebel, Eric David ,  Vian, Trina Rae

IPC: C12Q1/04

CPC classification number: G01N33/554 ,  G01N15/0205 ,  G01N21/07 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/75 ,  G01N21/76 ,  G01N33/54373 ,  G01N33/54393 ,  G01N33/56983 ,  G01N33/582 ,  G01N2021/6439 ,  G01N2201/025 ,  G01N2201/061 ,  Y10S435/808 ,  Y10S436/805

Abstract: The invention relates to optoelectronic systems for detecting one or more target particles, for example bacteria and antigens. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, for example aequorin or indo-1, thereby producing a measurable optical signal.

Abstract translation: 本发明涉及用于检测一种或多种目标颗粒（例如细菌和抗原）的光电子系统。 该系统包括反应室，样品收集器，光学检测器和含有细胞的储存器，每个细胞具有存在于每个细胞表面上的受体并且对待检测的目标颗粒具有特异性，其中结合 目标颗粒与受体直接或间接激活报道分子，例如水母发光蛋白或吲哚-1，由此产生可测量的光学信号。

公开(公告)号：EP1750129B1

公开(公告)日：2011-04-20

申请号：EP06022907.7

申请日：2002-02-06

Applicant: Massachusetts Institute of Technology

Inventor： Harper, James Douglas ,  Mathews, Richard Hart ,  Johnson, Bernadette ,  Petrovick, Martha Susan ,  Rundell, Ann ,  Nargi, Frances Ellen ,  Stephens, Timothy ,  Mendenhall, Linda Marie ,  Hollis, Mark Alexander ,  Young, Albert M. ,  Rider, Todd Harrison ,  Schwoebel, Eric David ,  Vian, Trina Rae

IPC: C12Q1/04

CPC classification number: G01N33/554 ,  G01N15/0205 ,  G01N21/07 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/75 ,  G01N21/76 ,  G01N33/54373 ,  G01N33/54393 ,  G01N33/56983 ,  G01N33/582 ,  G01N2021/6439 ,  G01N2201/025 ,  G01N2201/061 ,  Y10S435/808 ,  Y10S436/805