公开(公告)号：US10954375B2

公开(公告)日：2021-03-23

申请号：US15172131

申请日：2016-06-02

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Xuanhe Zhao ,  Shaoting Lin ,  Hyunwoo Yuk ,  Teng Zhang ,  German A P Hernandez

IPC: C08L33/26 ,  C09D201/02 ,  B32B27/04 ,  B32B27/30 ,  B05D3/04 ,  B05D3/10 ,  C08L35/00 ,  C09D133/26 ,  C09D135/00 ,  C09J133/26 ,  C09J135/00 ,  H01B1/12

Abstract: A robust hydrogel-solid hybrid formed of a substrate material having a nonporous and non-topographically patterned surface and a tough hydrogel bonded to the surface, the tough hydrogel having over 90 wt % water, and the hydrogel being bonded to provide interfacial toughness over 300 Jm−2, and even over 1000 Jm−2. The hydrogel is formed of polyacrylamide or polyethylene glycol diacrylate, which provide long-chain polymer networks, and chitosan, hyaluronan, or alginate, which provide mechanically dissipative components. An anchor, which can be a silane, a sulfide, or an amine, is disposed between the surface and the hydrogel to provide chemical bonding between the surface and the long-chain networks of the hydrogel.

公开(公告)号：US20190320705A1

公开(公告)日：2019-10-24

申请号：US16504165

申请日：2019-07-05

Applicant: Massachusetts Institute of Technology ,  Syracuse University

Inventor： Wen Wang ,  Lining Yao ,  Chin-Yi Cheng ,  Teng Zhang ,  Hiroshi Ishii ,  Daniel Wang ,  Daniel Levine

IPC: A23P20/20 ,  A23L27/00 ,  A23L5/00 ,  A23L29/281

Abstract: An edible structure may comprise a gelatin film and fiber strips. The gelatin film may have a higher density of gelatin in a first layer of the film than in a second layer of the film. The fiber strips may be attached to the first layer, and may have an initial orientation, thickness and density. The structure may be configured to undergo a shape transformation when the apparatus hydrates. During the transformation, the film may transform from a flat film into a curved, 3D film. Which specific shape results from the transformation may depend, at least in part, on the initial orientation, thickness and density of the fiber strips. The film may include flavorings or other additives. In some cases, the transformation may change a texture of the structure. In some cases, the transformation may be caused, at least in part, by a change in temperature.

公开(公告)号：US20180103678A1

公开(公告)日：2018-04-19

申请号：US15787639

申请日：2017-10-18

Applicant: Massachusetts Institute of Technology ,  Syracuse University

Inventor： Wen Wang ,  Lining Yao ,  Chin-Yi Cheng ,  Teng Zhang ,  Hiroshi Ishii ,  Daniel Wang ,  Daniel Levine

IPC: A23P20/20

CPC classification number: A23P20/20 ,  A23L5/55 ,  A23L27/79 ,  A23L29/284

Abstract: An edible structure may comprise a gelatin film and fiber strips. The gelatin film may have a higher density of gelatin in a first layer of the film than in a second layer of the film. The fiber strips may be attached to the first layer, and may have an initial orientation, thickness and density. The structure may be configured to undergo a shape transformation when the apparatus hydrates. During the transformation, the film may transform from a flat film into a curved, 3D film. Which specific shape results from the transformation may depend, at least in part, on the initial orientation, thickness and density of the fiber strips. The film may include flavorings or other additives. In some cases, the transformation may change a texture of the structure. In some cases, the transformation may be caused, at least in part, by a change in temperature.

公开(公告)号：US20170226339A1

公开(公告)日：2017-08-10

申请号：US15172131

申请日：2016-06-02

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Xuanhe Zhao ,  Shaoting Lin ,  Hyunwoo Yuk ,  Teng Zhang ,  German Alberto Parada

IPC: C08L33/26 ,  C09D133/26 ,  C08L35/00 ,  B05D3/04 ,  C09D135/00 ,  H01B1/12 ,  B05D3/10 ,  C09J133/26 ,  C09J135/00

CPC classification number: C08L33/26 ,  B05D3/044 ,  B05D3/10 ,  B32B27/04 ,  B32B27/308 ,  C08L35/00 ,  C08L2205/04 ,  C09D133/26 ,  C09D135/00 ,  C09D201/02 ,  C09J133/26 ,  C09J135/00 ,  H01B1/122

Abstract: Chemically anchoring long-chain polymer networks of tough hydrogels on solid surfaces can represent a general strategy to design tough and functional bonding between hydrogels and solid materials, achieving interfacial toughness over 1000 Jm−2.

公开(公告)号：US20170136180A1

公开(公告)日：2017-05-18

申请号：US15274218

申请日：2016-09-23

Applicant: Massachusetts Institute of Technology

Inventor： Xuanhe Zhao ,  Shaoting Lin ,  Hyunwoo Yuk ,  Teng Zhang

IPC: A61M5/172 ,  A61K9/70 ,  A61K9/06 ,  A61M35/00 ,  A61K9/00

CPC classification number: A61M5/1723 ,  A61K9/0004 ,  A61K9/0009 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0053 ,  A61K9/0097 ,  A61K9/06 ,  A61K9/7007 ,  A61K47/32 ,  A61K47/34 ,  A61M5/14 ,  A61M35/00 ,  A61M2230/005 ,  A61M2230/50

Abstract: A tough biocompatible hydrogel having one or more drug delivery components, deformable conductors, and/or rigid electronic components incorporated therein in such a way that robust interfaces are formed between the hydrogel and the various components. The resulting hydrogel device provides a highly deformable hydrogel composite in which the reliability and functionality of the incorporated components are maintained even under states of large deformation, and from which one or more drugs can be delivered in a controlled and sustained manner regardless of the state of deformation.