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    METHODS AND DEVICES FOR TAILORING A BOLUS DELIVERY PATTERN
    1.
    发明申请
    METHODS AND DEVICES FOR TAILORING A BOLUS DELIVERY PATTERN 审中-公开

    公开(公告)号：WO2010029551A3

    公开(公告)日：2010-03-18

    申请号：PCT/IL2009/000888

    申请日：2009-09-10

    Applicant: MEDINGO LTD. ,  YODFAT, Ofer ,  SHAPIRA, Gali ,  LEVY, Aharon

    Inventor： YODFAT, Ofer ,  SHAPIRA, Gali ,  LEVY, Aharon

    IPC: G06F19/00

    Abstract: Methods and devices for delivering therapeutic fluid to the body are described. The method may include determining a bolus delivery pattern based on a specific dietary intake of a patient and delivering the therapeutic fluid into the patient's body based, at least in part, on the determined bolus delivery pattern. The devices used in conjunction with the disclosed methods may include a controller to determine a bolus delivery pattern based on a specific dietary intake of the patient and an infusion pump to deliver the therapeutic fluid into the patient's body based, at least in part, on the determined bolus delivery pattern.

    A METHOD SYSTEM AND DEVICE FOR ASSESSING INSULIN SENSITIVITY
    2.
    发明申请
    A METHOD SYSTEM AND DEVICE FOR ASSESSING INSULIN SENSITIVITY 审中-公开
    用于评估胰岛素敏感性的方法系统和装置

    公开(公告)号：WO2009001348A1

    公开(公告)日：2008-12-31

    申请号：PCT/IL2008/000862

    申请日：2008-06-25

    Applicant: MEDINGO LTD. ,  YODFAT, Ofer ,  SHAPIRA, Gali ,  GESCHEIT, Iddo, M.

    Inventor： YODFAT, Ofer ,  SHAPIRA, Gali ,  GESCHEIT, Iddo, M.

    IPC: G06F19/00 ,  G01N33/66

    CPC classification number: A61M5/1723 ,  A61M5/1413 ,  A61M5/14244 ,  A61M5/14248 ,  A61M2005/14296 ,  A61M2230/20 ,  G01N33/66 ,  G01N2800/042 ,  G06F19/00 ,  G06F19/3456 ,  G16H20/17 ,  G16H50/50

    Abstract: A method and a system for determining insulin sensitivity (IS) is described. In one aspect the method and the system can be.implemented by receiving a first parameter corresponding to an insulin dose in a subcutaneous tissue;. applying a first kinetic. model to obtain a plasma insulin concentration based on the first parameter; receiving a second parameter corresponding to a plasma glucose concentration; determining the insulin sensitivity (IS) based on the plasma insulin concentration and the second parameter. In the preferred methods, the level of plasma insulin in a diabetic patient is predicted by means of the Kobayashi's model on the basis of the rate of continuous s.c. insulin infusion,.and IS is calculated by means of the QUICKI or the HOMA model on the basis of this prediction and the glucose data.

    Abstract translation: 描述了用于确定胰岛素敏感性（IS）的方法和系统。 在一个方面，该方法和系统可以通过接收对应于皮下组织中的胰岛素剂量的第一参数来实现。 应用第一动力学。 模型，以获得基于第一参数的血浆胰岛素浓度; 接收对应于血浆葡萄糖浓度的第二参数; 基于血浆胰岛素浓度和第二参数确定胰岛素敏感性（IS）。 在优选的方法中，糖尿病患者的血浆胰岛素水平是通过Kobayashi模型根据连续血糖的速率预测的。 基于该预测和葡萄糖数据，通过QUICKI或HOMA模型计算胰岛素输注，IS。

    ASSESSING RESIDUAL INSULIN TIME
    5.
    发明申请
    ASSESSING RESIDUAL INSULIN TIME 审中-公开
    评估残留胰岛素时间

    公开(公告)号：WO2009060433A1

    公开(公告)日：2009-05-14

    申请号：PCT/IL2008/001444

    申请日：2008-11-04

    Applicant: MEDINGO LTD. ,  YODFAT, Ofer ,  SHAPIRA, Gali

    Inventor： YODFAT, Ofer ,  SHAPIRA, Gali

    IPC: A61B5/00 ,  G06F19/00

    CPC classification number: G06F19/3456 ,  A61B5/14532 ,  A61B5/4839 ,  A61B2562/0295 ,  G06F19/00 ,  G16H15/00 ,  G16H40/63

    Abstract: Methods, systems and devices for assessing residual insulin time of a patient are provided. In one embodiment, the method and the device can be implemented by receiving a confirmation that an insulin dose has been administered to the patient; repetitively receiving a value corresponding to the patient's blood glucose level; identifying at least two consecutively received values based on a predetermined criteria; and, selecting the residual insulin time corresponding to a time period between the confirmation that the insulin dose has been administered and a time corresponding to the identification of the at least two consecutively received values.

    Abstract translation: 提供了用于评估患者残留胰岛素时间的方法，系统和装置。 在一个实施方案中，可以通过接收对患者施用胰岛素剂量的确认来实施该方法和装置; 重复地接收对应于患者血糖水平的值; 基于预定标准来识别至少两个连续接收的值; 以及选择对应于已经施用了所述胰岛素剂量的确认之间的时间段的残留胰岛素时间与对所述至少两个连续接收值的识别相对应的时间。

    DEVICES, SYSTEMS AND METHODS FOR ADJUSTING FLUID DELIVERY PARAMETERS
    6.
    发明申请
    DEVICES, SYSTEMS AND METHODS FOR ADJUSTING FLUID DELIVERY PARAMETERS 审中-公开
    用于调节流体输送参数的装置，系统和方法

    公开(公告)号：WO2011030343A1

    公开(公告)日：2011-03-17

    申请号：PCT/IL2010/000744

    申请日：2010-09-07

    Applicant: MEDINGO LTD. ,  YODFAT, Ofer ,  SHAPIRA, Gali ,  GESCHEIT, Iddo M.

    Inventor： YODFAT, Ofer ,  SHAPIRA, Gali ,  GESCHEIT, Iddo M.

    IPC: A61K9/00

    CPC classification number: A61M5/16877 ,  A61M5/14244 ,  A61M5/16804 ,  A61M5/16831 ,  A61M5/172 ,  A61M2205/3569 ,  G06F19/3468

    Abstract: Devices, systems and methods for adjusting fluid delivery based on past or historical fluid delivery data and/or personal parameters of a user are disclosed. Devices, and corresponding systems and methods, may comprise a dispensing unit configured to deliver a fluid from a reservoir into the body of a user and a processor having instructions operating thereon to retrieve data relating to one or more time windows from a memory, assess a correction delivery for the one or more time windows based on the data, determine a new CIR value for the one or more time windows if the correction delivery regularly follows a meal bolus and/or determine a new basal delivery profile for the one or more time windows if the correction delivery regularly precedes a meal bolus.

    Abstract translation: 公开了用于基于过去或历史的流体输送数据和/或用户的个人参数来调节流体输送的装置，系统和方法。 设备和相应的系统和方法可以包括分配单元，其被配置为将流体从储存器输送到用户的身体中;以及处理器，其具有在其上操作的指令以从存储器检索与一个或多个时间窗口相关的数据， 基于数据对一个或多个时间窗口进行校正传送，如果校正传送定期地跟随膳食推注和/或确定一个或多个时间的新的基础传送配置文件，则确定一个或多个时间窗口的新的CIR值 如果校正交付经常在餐前推注，则窗口。

    DEVICE AND METHOD FOR ENHANCED SUBCUTANEOUS INSULIN ABSORPTION
    7.
    发明申请
    DEVICE AND METHOD FOR ENHANCED SUBCUTANEOUS INSULIN ABSORPTION 审中-公开

    公开(公告)号：WO2010023666A3

    公开(公告)日：2010-03-04

    申请号：PCT/IL2009/000827

    申请日：2009-08-27

    Applicant: MEDINGO LTD. ,  YODFAT, Ofer ,  SHAPIRA, Gali ,  GESCHEIT, Illai

    Inventor： YODFAT, Ofer ,  SHAPIRA, Gali ,  GESCHEIT, Illai

    IPC: A61M5/142 ,  A61M37/00 ,  A61B18/04 ,  A61B18/12

    Abstract: Products and methods directed to the improved infusion of fluids are disclosed. Such products and methods can be used to more efficiently and efficaciously administer therapeutic pharmaceuticals to a subject in need of treatment. In many instances, the systems comprise a therapeutic fluid delivery system and a mechanism for enhancing the absorption of the therapeutic fluid.. The enhancement of the absorption of the therapeutic fluid is generally performed locally i.e., at or near the site of administration of the therapeutic fluid. The system and methods can be used to deliver any number of therapeutic fluids including but not limited to insulin.

    DEVICE AND METHOD FOR PREVENTING DIABETIC COMPLICATIONS
    8.
    发明申请
    DEVICE AND METHOD FOR PREVENTING DIABETIC COMPLICATIONS 审中-公开
    用于预防糖尿病并发症的装置和方法

    公开(公告)号：WO2009060432A1

    公开(公告)日：2009-05-14

    申请号：PCT/IL2008/001443

    申请日：2008-11-04

    Applicant: MEDINGO LTD. ,  YODFAT, Ofer ,  SHAPIRA, Gali

    Inventor： YODFAT, Ofer ,  SHAPIRA, Gali

    IPC: A61B5/00 ,  A61M5/14

    CPC classification number: A61B5/14532 ,  A61B5/0002 ,  A61B5/145 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/6849 ,  A61B5/6865 ,  A61M5/14248 ,  A61M5/1723 ,  A61M2005/14252 ,  A61M2005/14268 ,  A61M2005/1726 ,  A61M2230/201

    Abstract: Methods, systems and devices for preventing diabetic complications are provided. In some embodiments, methods, systems and devices can be implemented using at least one subcutaneously insertable element, the element having a proximal portion and a distal portion, the proximal portion coupled to the housing, the distal portion configured for subcutaneous placement within a human body; a plurality of electrodes coupled to the distal portion of the at least one subcutaneously insertable element; and, a processor adapted to correlate a signal received from the plurality of electrodes to a concentration of ketone in the human body.

    Abstract translation: 提供了用于预防糖尿病并发症的方法，系统和装置。 在一些实施例中，方法，系统和装置可以使用至少一个皮下可插入元件实现，所述元件具有近端部分和远端部分，所述近端部分联接到所述外壳，所述远端部分被配置为皮下放置在人体内 ; 耦合到所述至少一个皮下可插入元件的远端部分的多个电极; 以及适于将从多个电极接收的信号与人体中的酮浓度相关联的处理器。

    A DEVICE FOR DRUG DELIVERY
    9.
    发明申请
    A DEVICE FOR DRUG DELIVERY 审中-公开
    用于药物递送的装置

    公开(公告)号：WO2009004627A2

    公开(公告)日：2009-01-08

    申请号：PCT/IL2008/000915

    申请日：2008-07-02

    Applicant: MEDINGO LTD. ,  YODFAT, Ofer ,  SHAPIRA, Gali

    Inventor： YODFAT, Ofer ,  SHAPIRA, Gali

    IPC: A61M5/14 ,  A61M5/142 ,  A61M5/172

    CPC classification number: A61M5/1723 ,  A61M5/1408 ,  A61M5/14228 ,  A61M5/14244 ,  A61M2005/14208 ,  A61M2005/1726

    Abstract: Delivery of more than one therapeutic fluid as a means to control symptoms of a health conditions is disclosed. More than one therapeutic fluid may be dispensed from more than one reservoir and delivered to a user's body via one or more cannula that penetrate the skin. The therapeutic fluids may be delivered by action of one or more pumping mechanisms that may be controlled by a processor in a portable, ambulatory device. The therapeutic fluids may optionally be insulin and one or more of an amylin analog, pramlintide acetate and an exenatide, and the health condition may optionally be diabetes.

    Abstract translation: 公开了递送多于一种治疗液作为控制健康状况的症状的手段。 可以从多于一个储存器分配多于一个治疗流体，并通过穿透皮肤的一个或多个插管递送至使用者的身体。 治疗性流体可以通过一个或多个泵送机构的作用递送，该泵送机构可以由便携式移动装置中的处理器控制。 治疗性流体可以任选地是胰岛素和一种或多种胰岛淀粉样多肽类似物，普兰米特乙酸盐和艾塞那肽，并且健康状况可以任选地是糖尿病。

    DEVICES, SYSTEMS AND METHODS FOR QUANTIFYING BOLUS DOSES ACCORDING TO USER PARAMETERS
    10.
    发明申请
    DEVICES, SYSTEMS AND METHODS FOR QUANTIFYING BOLUS DOSES ACCORDING TO USER PARAMETERS 审中-公开
    根据用户参数量化固定剂量的装置，系统和方法

    公开(公告)号：WO2011033509A1

    公开(公告)日：2011-03-24

    申请号：PCT/IL2010/000757

    申请日：2010-09-16

    Applicant: MEDINGO LTD. ,  YODFAT, Ofer ,  SHAPIRA, Gali ,  GESCHEIT, Iddo, M.

    Inventor： YODFAT, Ofer ,  SHAPIRA, Gali ,  GESCHEIT, Iddo, M.

    IPC: A61K9/22

    CPC classification number: A61M5/1723 ,  A61B5/14532 ,  A61B5/4839 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17

    Abstract: Devices, systems and methods for determining a recommended bolus dose of therapeutic fluid to be delivered to the body are disclosed. Such a recommended bolus dose may be provided by establishing an initial bolus dose for a user based on one or more first parameters relating to the user and adjusting (e.g., increasing or decreasing) this initial bolus dose amount based on one or more second user parameters by multiplying the initial bolus dose by one or more multiplier values that correlate to at least one of the second parameters and/or by adding or subtracting an absolute value of at least one of the second parameters from the initial bolus dose amount.

    Abstract translation: 公开了用于确定要输送到身体的治疗流体的推荐推注剂量的装置，系统和方法。 可以通过基于与用户相关的一个或多个第一参数建立用户的初始推注剂量来提供这种推荐的推注剂量，并且基于一个或多个第二用户参数来调整（例如，增加或减少）该初始推注剂量 通过将初始推注剂量乘以与第二参数中的至少一个相关联的一个或多个乘数值和/或通过从初始推注剂量来添加或减去至少一个第二参数的绝对值。

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