-
公开(公告)号:US20190033223A1
公开(公告)日:2019-01-31
申请号:US15752706
申请日:2016-08-19
Inventor: Chris Hand , Oliver Hofmann , Gihan Ryu , Miguel Ramon , Philip Benzie , Christopher John Kay
IPC: G01N21/84 , B01L3/00 , G01N33/558 , G01N21/64
Abstract: An assay device for the quantitative determination of the concentration of at least one analyte in a liquid sample. The device comprises a lateral flow membrane (46) comprising a plurality of test regions (41A, 41B) and formed from a light transmissive material, a plurality (44A, 44B) of planar organic light emitting diode (OLED) emitters comprising an emission layer of an organic electroluminescent material, and a plurality (49A, 49B) of planar organic photodetectors (OPDs) comprising an absorption layer of an organic photovoltaic material. Each test region comprises an immobilised component for retaining analyte tagging particles. Each test region is aligned with the emission layer of one emitter and the absorption layer of one photodetector. The aligned emitter, photodetector, and test region form a group such that the emitter is capable of illuminating the test region and the photodetector is capable of detecting light from the test region. For each group, under conditions where the test region is wet and devoid of tagging particles the energised photodetector photocurrent that is produced is denoted i1, when the group emitter is the only emitter that is energised, and T2 when the emitter of another group is additionally energised. Cross-talk (C), is then represented by the black arrows, and is defined according to the equation: C=20 log10 (i1/(i2−i1)) C is arranged to be greater than about 20 dB for at least one group of the device.
-
公开(公告)号:US20180260775A1
公开(公告)日:2018-09-13
申请号:US15751065
申请日:2016-08-19
Applicant: Molecular Vision Limited
Inventor: Chris Hand , Oliver Hofmann , Gihan Ryu , Miguel Ramon , Neeraj Adsul
IPC: G06Q10/08
CPC classification number: G06Q10/0832 , G01N21/8483 , G01N2021/8488
Abstract: A computer system and method is provided to filter clearance sensor data output by a sensor system during a load/offload procedure of a first object relative to a second object. A processing device of the computer system is configured to access hard threshold data, unique threshold data, and sensor data output by the sensor system sensing aspects of the load/offload procedure. The processing device is further configured to determine whether the sensor data exceeds the unique threshold, determine whether the sensor data that is determined to exceed the unique threshold is voidable data related to a noncritical event, and generate filtered sensor data that includes modifications to the voidable data.
-
公开(公告)号:US20180231464A1
公开(公告)日:2018-08-16
申请号:US15751074
申请日:2016-08-19
Applicant: Molecular Vision Limited
Inventor: Chris Hand , Oliver Hofmann , Gihan Ryu , Miguel Ramon , Dene Baldwin
IPC: G01N21/64 , G01N21/84 , G01N33/558 , G01N21/78
CPC classification number: G01N21/645 , G01N21/6428 , G01N21/78 , G01N21/8483 , G01N33/558 , G01N2021/6439 , G01N2021/7786 , G01N2201/0628
Abstract: An assay device for the quantitative determination of the concentration of at least one analyte in a liquid sample comprises a planar emitter (2), a planar detector (3), a lateral flow membrane (4) interposed between the emitter (2) and the detector (3), a conjugate pad (5) in fluid communication with a proximal end of the lateral flow membrane (4), the conjugate pad (5) comprising optically detectable tagging particles bound to a first assay component, a sample pad (6) in fluid communication with the conjugate pad (5) and arranged to receive the liquid sample, and a wicking pad (7) in fluid communication with a distal end of the lateral flow membrane (4). The lateral flow membrane (4) is formed from a light transmissive material and is capable of transporting fluid from the conjugate pad (5) to the wicking pad (7) by capillary action. The lateral flow membrane (4) comprises at least one test region (8, 12) comprising an immobilised second assay component for retaining the tagging particles in the test region (8, 12) in dependence on the binding between the analyte, the first assay component and the second assay component in order to generate a concentration of tagging particles in the test region (8, 12) that is indicative of the concentration of the analyte in the liquid sample. The emitter (2) comprises an emission layer (9, 16) of an organic electroluminescent material and the emission layer (9, 16) is aligned with the test region (8, 12) of the lateral flow membrane 4, whereby the emitter (2) is capable of illuminating the test region (8, 12). The detector (3) comprises an absorption layer (10, 15) of an organic photovoltaic material and the absorption layer (10, 15) is aligned with the test region (8, 12) of the lateral flow membrane 4, whereby the detector (3) is capable of detecting light from the test region (8, 12).
-
公开(公告)号:US20180224378A1
公开(公告)日:2018-08-09
申请号:US15751060
申请日:2016-08-19
Inventor: Christopher John Kay , Chris Hand , Oliver Hofmann , Gihan Ryu , Miguel Ramon , llaria Grizzi
IPC: G01N21/77 , B01L3/00 , G01N33/558 , G01N33/543 , H01L51/00 , G01N33/58 , H01L27/28
CPC classification number: G01N21/77 , B01L3/5023 , B01L2300/0645 , B01L2300/069 , B01L2300/12 , B01L2400/0406 , G01N21/8483 , G01N33/54386 , G01N33/558 , G01N33/582 , G01N2021/7783 , G01N2021/8488 , H01L27/288 , H01L51/0036 , H01L51/0046 , H01L51/0085
Abstract: An improved optical detection unit for an assay device, such as a lateral flow device, for the quantitative determination of the concentration of an analyte in a liquid sample, and an assay device comprising the same. The detection unit comprises an organic light emitting diode (OLED) emitter that has an emission spectrum E within the wavelength range from λ1 to λ2, and an organic photodiode detector (OPD) that has a light detection spectrum S within the wavelength range from λ1 to λ2. The detection unit has a test region that comprises a light absorbing component that has an absorbance spectrum A within the wavelength range from λ1 to λ2. The test region is positioned adjacent to the emitter and the detector to form an optical pathway from the light emitting diode to the photodiode through at least a portion of the test region. Formula M defines a relationship between E, S and A, and M is less than about 0.4.
-
-
-