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    ASSAY DEVICE
    1.
    发明申请
    ASSAY DEVICE 审中-公开

    公开(公告)号：US20190033223A1

    公开(公告)日：2019-01-31

    申请号：US15752706

    申请日：2016-08-19

    Applicant: Molecular Vision Limited ,  Cambridge Display Technology Limited

    Inventor： Chris Hand ,  Oliver Hofmann ,  Gihan Ryu ,  Miguel Ramon ,  Philip Benzie ,  Christopher John Kay

    IPC: G01N21/84 ,  B01L3/00 ,  G01N33/558 ,  G01N21/64

    Abstract: An assay device for the quantitative determination of the concentration of at least one analyte in a liquid sample. The device comprises a lateral flow membrane (46) comprising a plurality of test regions (41A, 41B) and formed from a light transmissive material, a plurality (44A, 44B) of planar organic light emitting diode (OLED) emitters comprising an emission layer of an organic electroluminescent material, and a plurality (49A, 49B) of planar organic photodetectors (OPDs) comprising an absorption layer of an organic photovoltaic material. Each test region comprises an immobilised component for retaining analyte tagging particles. Each test region is aligned with the emission layer of one emitter and the absorption layer of one photodetector. The aligned emitter, photodetector, and test region form a group such that the emitter is capable of illuminating the test region and the photodetector is capable of detecting light from the test region. For each group, under conditions where the test region is wet and devoid of tagging particles the energised photodetector photocurrent that is produced is denoted i1, when the group emitter is the only emitter that is energised, and T2 when the emitter of another group is additionally energised. Cross-talk (C), is then represented by the black arrows, and is defined according to the equation: C=20 log10 (i1/(i2−i1)) C is arranged to be greater than about 20 dB for at least one group of the device.

    ASSAY DEVICE
    2.
    发明申请
    ASSAY DEVICE 审中-公开

    公开(公告)号：US20180260775A1

    公开(公告)日：2018-09-13

    申请号：US15751065

    申请日：2016-08-19

    Applicant: Molecular Vision Limited

    Inventor： Chris Hand ,  Oliver Hofmann ,  Gihan Ryu ,  Miguel Ramon ,  Neeraj Adsul

    IPC: G06Q10/08

    CPC classification number: G06Q10/0832 ,  G01N21/8483 ,  G01N2021/8488

    Abstract: A computer system and method is provided to filter clearance sensor data output by a sensor system during a load/offload procedure of a first object relative to a second object. A processing device of the computer system is configured to access hard threshold data, unique threshold data, and sensor data output by the sensor system sensing aspects of the load/offload procedure. The processing device is further configured to determine whether the sensor data exceeds the unique threshold, determine whether the sensor data that is determined to exceed the unique threshold is voidable data related to a noncritical event, and generate filtered sensor data that includes modifications to the voidable data.

    ASSAY DEVICE
    3.
    发明申请
    ASSAY DEVICE 审中-公开

    公开(公告)号：US20180231464A1

    公开(公告)日：2018-08-16

    申请号：US15751074

    申请日：2016-08-19

    Applicant: Molecular Vision Limited

    Inventor： Chris Hand ,  Oliver Hofmann ,  Gihan Ryu ,  Miguel Ramon ,  Dene Baldwin

    IPC: G01N21/64 ,  G01N21/84 ,  G01N33/558 ,  G01N21/78

    CPC classification number: G01N21/645 ,  G01N21/6428 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/558 ,  G01N2021/6439 ,  G01N2021/7786 ,  G01N2201/0628

    Abstract: An assay device for the quantitative determination of the concentration of at least one analyte in a liquid sample comprises a planar emitter (2), a planar detector (3), a lateral flow membrane (4) interposed between the emitter (2) and the detector (3), a conjugate pad (5) in fluid communication with a proximal end of the lateral flow membrane (4), the conjugate pad (5) comprising optically detectable tagging particles bound to a first assay component, a sample pad (6) in fluid communication with the conjugate pad (5) and arranged to receive the liquid sample, and a wicking pad (7) in fluid communication with a distal end of the lateral flow membrane (4). The lateral flow membrane (4) is formed from a light transmissive material and is capable of transporting fluid from the conjugate pad (5) to the wicking pad (7) by capillary action. The lateral flow membrane (4) comprises at least one test region (8, 12) comprising an immobilised second assay component for retaining the tagging particles in the test region (8, 12) in dependence on the binding between the analyte, the first assay component and the second assay component in order to generate a concentration of tagging particles in the test region (8, 12) that is indicative of the concentration of the analyte in the liquid sample. The emitter (2) comprises an emission layer (9, 16) of an organic electroluminescent material and the emission layer (9, 16) is aligned with the test region (8, 12) of the lateral flow membrane 4, whereby the emitter (2) is capable of illuminating the test region (8, 12). The detector (3) comprises an absorption layer (10, 15) of an organic photovoltaic material and the absorption layer (10, 15) is aligned with the test region (8, 12) of the lateral flow membrane 4, whereby the detector (3) is capable of detecting light from the test region (8, 12).

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