公开(公告)号：WO2022216584A1

公开(公告)日：2022-10-13

申请号：PCT/US2022/023264

申请日：2022-04-04

Applicant: NEC LABORATORIES AMERICA, INC.

Inventor： MIN, Renqiang ,  GRAF, Peter Hans ,  HAN, Ligong

IPC: G16B40/00 ,  G16B15/30 ,  G06N3/04 ,  G06N3/08

Abstract: A method is provided for generating new binding peptides to MHC proteins includes training (430), by a processor device, a Generative Adversarial Network GAN having a generator and a discriminator only on a set of binding peptide sequences given training data including the set of binding peptide sequences and a set of non-binding peptide sequences. A GAN training objective includes the discriminator being iteratively updated to distinguish generated peptide sequences from sampled binding peptide sequences as fake or real and the generator being iteratively updated to fool the discriminator. The training includes optimizing (440) the GAN training objective while learning two projection vectors for a binding class with two cross-entropy losses. A first loss discriminating binding peptide sequences in the training data from non-binding peptide sequences in the training data. A second loss discriminating generated binding peptide sequences from non-binding peptide sequences in the training data.