公开(公告)号：WO2016009442A1

公开(公告)日：2016-01-21

申请号：PCT/IN2014/000728

申请日：2014-11-20

Applicant: NEON LABORATORIES LTD.

Inventor： DALVI, Mahesh Bhagoji ,  TARADE, Pradeep Kisan

IPC: C07D201/14 ,  C07J1/00 ,  A61K31/568

CPC classification number: C07J43/003 ,  A61K31/568

Abstract: The invention discloses a novel method for preparing neuromuscular blocking agents using aryl esters as a reagent of di-acylation as well as highly regioselective mono-acylation of androstane-diols.

Abstract translation: 本发明公开了一种使用芳基酯作为二酰化试剂以及雄甾烷二醇的高选择性单酰化制备神经肌肉阻滞剂的新方法。

公开(公告)号：WO2012017443A1

公开(公告)日：2012-02-09

申请号：PCT/IN2010/000700

申请日：2010-10-27

Applicant: NEON LABORATORIES LTD. ,  DALVI, Mahesh Bhagoji ,  KENNY, Rajesh Shashikant ,  TARADE, Pradeep Kisan

Inventor： DALVI, Mahesh Bhagoji ,  KENNY, Rajesh Shashikant ,  TARADE, Pradeep Kisan

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The invention discloses a process for preparation of highly pure dialkyl pemetrexed by reacting a 2-(4-hydroxy-6-aminopyrrolo(2,3-d)pyrimidin-3-yl)ethylbenzoic acid with a glutamatic acid diester or its salt in presence of a safe, mild, inexpensive, non-oxidative and easy to handle reagent such as substituted triphenyl phosphate. The invention further discloses purification of dialkyl pemetrexed by crystallization or trituration and conversion of purified dialkyl pemetrexed to pemetrexed or its disodium salt.

Abstract translation: 本发明公开了一种通过使2-（4-羟基-6-氨基吡咯并（2,3-d）嘧啶-3-基）乙基苯甲酸与谷氨酸二酯或其盐在存在下反应制备高纯二甲基培美曲塞的方法 一种安全，温和，便宜，非氧化和易于处理的试剂，如取代的磷酸三苯酯。 本发明还公开了通过结晶或研磨并将精制二甲基培美曲塞转化为培美曲塞或其二钠盐来纯化二甲基培美曲塞。

公开(公告)号：WO2013069025A1

公开(公告)日：2013-05-16

申请号：PCT/IN2012/000013

申请日：2012-01-05

Applicant: NEON LABORATORIES LTD. ,  DALVI, Mahesh Bhagoji ,  KENNY, Rajesh Shashikant ,  TARADE, Pradeep Kisan

Inventor： DALVI, Mahesh Bhagoji ,  KENNY, Rajesh Shashikant ,  TARADE, Pradeep Kisan

IPC: C07D233/58 ,  B01D9/02 ,  C07B57/00

CPC classification number: C07D233/58 ,  C07B57/00

Abstract: The invention discloses a novel process for preparation of dexmedetomidine in higher yield and with enantiomeric purity more than 99%.

Abstract translation: 本发明公开了一种以更高产率制备右美托咪定并具有99％以上对映体纯度的新方法。

公开(公告)号：WO2012147090A1

公开(公告)日：2012-11-01

申请号：PCT/IN2011/000727

申请日：2011-10-20

Applicant: NEON LABORATORIES LTD. ,  DALVI, Mahesh Bhagoji ,  TARADE, Pradeep Kisan

Inventor： DALVI, Mahesh Bhagoji ,  TARADE, Pradeep Kisan

IPC: C07J75/00

CPC classification number: C07J43/003

Abstract: The invention discloses a novel process for quaternization of (2β,3α,5α,16β,17β)-2,16-bispiperidino-3,17-diacetoxy-5-androstane with methyl bromide in presence of a cyclic ether. The invention further discloses purification of quaternary salt to provide highly pure vecuronium bromide with unspecified impurity level not more than 0.1%.

Abstract translation: 本发明公开了一种在环醚存在下用甲基溴季铵化（2β，3a，5a，16β，17β）-2,16-双哌啶-3,17-二乙酰氧基-5-雄甾烷酯的新方法。 本发明还公开了季盐的纯化，以提供不超过0.1％的未指定杂质含量的高纯度维库溴铵。

公开(公告)号：WO2012131699A1

公开(公告)日：2012-10-04

申请号：PCT/IN2011/000721

申请日：2011-10-18

Applicant: NEON LABORATORIES LTD. ,  DALVI, Mahesh Bhagoji ,  KENNY, Rajesh Shashikant ,  TARADE, Pradeep Kisan ,  CHINCHKAR, Dattatray Krishna

Inventor： DALVI, Mahesh Bhagoji ,  KENNY, Rajesh Shashikant ,  TARADE, Pradeep Kisan ,  CHINCHKAR, Dattatray Krishna

IPC: C07C269/06 ,  C07C271/44

CPC classification number: C07C269/06 ,  C07C271/44

Abstract: The invention discloses a novel process for preparation of highly pure 3-dimethylaminophenyl dimethylcarbamate via formation of aryl dimethylcarbamate which can be easily obtained from diaryl carbonate and dimethylamine.

Abstract translation: 本发明公开了一种通过形成芳基二甲基氨基甲酸酯制备高纯度3-二甲基氨基苯基二甲基氨基甲酸酯的新方法，其可以容易地从碳酸二芳基酯和二甲胺获得。