公开(公告)号：KR840000192B1

公开(公告)日：1984-02-28

申请号：KR800003456

申请日：1980-09-02

Applicant: NIPPON SODA CO

Inventor： ISHIMITSU KEIICHI ,  YAMADA TOMIO ,  TAKAHASHI HIDEMITSU ,  KASAHARA ISAMU ,  MATSUDA MICHIHIKO ,  SOMA SHUICHI

IPC: C07C215/00 ,  C07C93/26

公开(公告)号：FR2464941A1

公开(公告)日：1981-03-20

申请号：FR8019273

申请日：1980-09-05

Applicant: NIPPON SODA CO

Inventor： ISHIMITSU KEIICHI ,  KASAHARA ISAMU ,  YAMADA TOMIO ,  MATSUDA MICHIHIKO ,  TAKAHASHI HIDEMITSU ,  SOMA SHUICHI

IPC: A01N37/02 ,  A01N37/10 ,  A01N37/44 ,  A01N37/48 ,  A01N43/30 ,  C07C69/612 ,  C07C255/59 ,  C07C93/26 ,  C07C121/80 ,  A01N33/06 ,  A01N37/00

Abstract: Isovaleric acid derivatives having the formula wherein typical representations of X is halophenyl, R1 is hydrogen or cyano, R2 is hydrogen or lower alkyl, and Y is halophenyl. These derivatives possess insecticidal and acaricidal properties. The process for their preparation is described.

公开(公告)号：DE3033358A1

公开(公告)日：1981-03-19

申请号：DE3033358

申请日：1980-09-04

Applicant: NIPPON SODA CO

Inventor： ISHIMITSU KEIICHI ,  KASAHARA ISAMU ,  YAMADA TOMIO ,  MATSUDA MICHIHIKO ,  TAKAHASHI HIDEMITSU ,  SOMA SHUICHI

IPC: A01N37/02 ,  A01N37/10 ,  A01N37/44 ,  A01N37/48 ,  A01N43/30 ,  C07C69/612 ,  C07C255/59 ,  C07C93/26 ,  C07C121/80

Abstract: Isovaleric acid derivatives having the formula wherein typical representations of X is halophenyl, R1 is hydrogen or cyano, R2 is hydrogen or lower alkyl, and Y is halophenyl. These derivatives possess insecticidal and acaricidal properties. The process for their preparation is described.

公开(公告)号：JPH06199842A

公开(公告)日：1994-07-19

申请号：JP35126492

申请日：1992-12-07

Applicant: NIPPON SODA CO

Inventor： MOCHIZUKI NOBUO ,  SOMA SHUICHI ,  SASAKI TAKAYOSHI ,  UCHIDA SEIICHI ,  HATANO MASAMI

IPC: A61K31/50 ,  A61P7/02 ,  A61P11/08 ,  A61P43/00 ,  C07D403/06

Abstract: PURPOSE:To provide a new pyridazinone derivative having blood platelet coagulation inhibitory activity and phosphodiesterase inhibitory activity, also safe and causing no side effects, thus useful as an antithrombotic agent, medicine for chronic obstructive pulmonary diseases, etc. CONSTITUTION:The objective pyridazinone derivative of formula I [R is H or lower alkyl; R and R are each H or lower alkyl, or combined into (CH2)n (n is 2-5)], e.g. (E) 4,5-dihydro-6-[(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indole-5-yl) ethenyl]-5-methyl-3(2H)-pyridazinone. The compound of the formula I can be obtained by reaction between a compound of formula II (R is H or lower alkyl) and hydrazine followed by, in the case where the aimed compound with unsaturated pyridazine nucleus is desired, reaction with a dehydrogenating agent. The compound of the formula I is also useful for treatments of hypertension, ulcers, diabetes, cancers, etc.