公开(公告)号：US11708575B2

公开(公告)日：2023-07-25

申请号：US16685283

申请日：2019-11-15

Applicant: Nitto Denko Corporation

Inventor： Bharat Majeti ,  Jean-Pierre Clamme ,  Li Wang ,  Roger C. Adami ,  Wenbin Ying

IPC: A61K47/00 ,  A61K48/00 ,  C12N15/113 ,  A61P35/00 ,  A61K31/712 ,  A61K31/7125 ,  A61K9/16 ,  A61K47/24 ,  A61K9/14 ,  A61K9/19 ,  A61K47/28

CPC classification number: C12N15/113 ,  A61K9/141 ,  A61K9/1652 ,  A61K9/19 ,  A61K31/712 ,  A61K31/7125 ,  A61K47/24 ,  A61K47/28 ,  A61P35/00

Abstract: This invention provides formulations for use in distributing RNAi molecules targeted to a human GST-π for treating a malignant tumor in a subject. The formulation can include nanoparticles composed of an ionizable lipid, a DSPE lipid, and additional lipids. A drug product can be made by lyophilization of the formulation. This invention further provides methods for ameliorating or treating a malignant tumor by administering a therapeutically effective amount of a formulation containing the RNAi agents.

公开(公告)号：US20220242820A1

公开(公告)日：2022-08-04

申请号：US17658075

申请日：2022-04-05

Applicant: Nitto Denko Corporation

Inventor： Roger Adami ,  Hao Bai ,  John Gaudette ,  Bharat Majeti ,  Seiji Nukui ,  Kwok Yin Tsang ,  Hai Wang ,  Haiqing Yin ,  Wenbin Ying

IPC: C07C271/16 ,  C07D205/04 ,  C07D207/12 ,  C07C237/16 ,  C07D207/09 ,  C07D211/86 ,  C07D211/82 ,  C07D211/74 ,  C07F9/06 ,  A61K31/713 ,  C07F9/10 ,  A61K31/7105 ,  A61K9/127 ,  A61K9/51 ,  C07C237/08 ,  C07C237/50 ,  A61K47/16 ,  A61K47/22 ,  A61K47/24

Abstract: Ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, the compounds, compositions and methods are to provide nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

公开(公告)号：US11384051B2

公开(公告)日：2022-07-12

申请号：US16228054

申请日：2018-12-20

Applicant: Nitto Denko Corporation

Inventor： Roger Adami ,  Hao Bai ,  John Gaudette ,  Bharat Majeti ,  Seiji Nukui ,  Kwok Yin Tsang ,  Hai Wang ,  Haiqing Yin ,  Wenbin Ying

IPC: A61K31/713 ,  A61K31/7105 ,  A61K9/127 ,  A61K9/51 ,  A61K47/16 ,  A61K47/22 ,  A61K47/24 ,  C07C271/16 ,  C07D205/04 ,  C07D207/12 ,  C07C237/16 ,  C07D207/09 ,  C07D211/86 ,  C07D211/82 ,  C07D211/74 ,  C07F9/06 ,  C07F9/10 ,  C07C237/08 ,  C07C237/50

Abstract: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

公开(公告)号：US11359202B2

公开(公告)日：2022-06-14

申请号：US16451757

申请日：2019-06-25

Applicant: Nitto Denko Corporation

Inventor： Kenjirou Minomi ,  Jens Harborth ,  Cima Cina ,  Wenbin Ying ,  Jane Zheng ,  Narendra Vaish

IPC: C07H21/02 ,  C12N15/11 ,  C12N15/113

Abstract: This invention provides compounds, compositions and methods for modulating the expression of target genes using RNA interference. RNAi structures and molecules of this invention can be used for modulating or silencing the expression of genes, with high levels of RNAi activity and reduced off target actions. Advantageous structures include siRNAs targeted to any gene having one or more 2′-deoxy nucleotides located in the seed region. The RNA interference molecules can be used in methods for preventing or treating diseases.

公开(公告)号：USRE48887E1

公开(公告)日：2022-01-11

申请号：US16576102

申请日：2019-09-19

Applicant: Nitto Denko Corporation

Inventor： Yoshiro Niitsu ,  Kenjirou Minomi ,  Bharat Majeti ,  Li Wang ,  Jihua Liu ,  Roger Adami ,  Wenbin Ying

IPC: C07H21/04 ,  C12N15/113 ,  C07F9/6533 ,  C12Q1/02 ,  G01N33/58 ,  A61B5/00 ,  A61K49/00 ,  C07D311/30 ,  A61K31/713

Abstract: This invention provides compositions for use in distributing active agents for treating a malignant tumor in a subject. The compositions contain RNAi molecules targeted to a human GST-π, along with RNAi molecules targeted to a human p21, and a pharmaceutically acceptable carrier. The carrier can include nanoparticles composed of an ionizable lipid, a structural lipid, one or more stabilizer lipids, and a lipid for reducing immunogenicity of the nanoparticles. This invention further provides methods for preventing or treating a malignant tumor by administering a therapeutically effective amount of an RNAi composition.

公开(公告)号：US20200157540A1

公开(公告)日：2020-05-21

申请号：US16685283

申请日：2019-11-15

Applicant: Nitto Denko Corporation

Inventor： Bharat Majeti ,  Jean-Pierre Clamme ,  Li Wang ,  Roger C. Adami ,  Wenbin Ying

IPC: C12N15/113 ,  A61P35/00 ,  A61K31/712 ,  A61K31/7125 ,  A61K47/28 ,  A61K47/24 ,  A61K9/14 ,  A61K9/19 ,  A61K9/16

Abstract: This invention provides formulations for use in distributing RNAi molecules targeted to a human GST-π for treating a malignant tumor in a subject. The formulation can include nanoparticles composed of an ionizable lipid, a DSPE lipid, and additional lipids. A drug product can be made by lyophilization of the formulation. This invention further provides methods for ameliorating or treating a malignant tumor by administering a therapeutically effective amount of a formulation containing the RNAi agents.

公开(公告)号：US20190323015A1

公开(公告)日：2019-10-24

申请号：US16451757

申请日：2019-06-25

Applicant: Nitto Denko Corporation

Inventor： Kenjirou Minomi ,  Jens Harborth ,  Cima Cina ,  Wenbin Ying ,  Jane Zheng ,  Narendra Vaish

IPC: C12N15/113

Abstract: This invention provides compounds, compositions and methods for modulating the expression of target genes using RNA interference. RNAi structures and molecules of this invention can be used for modulating or silencing the expression of genes, with high levels of RNAi activity and reduced off target actions. Advantageous structures include siRNAs targeted to any gene having one or more 2′-deoxy nucleotides located in the seed region. The RNA interference molecules can be used in methods for preventing or treating diseases.

公开(公告)号：US10167253B2

公开(公告)日：2019-01-01

申请号：US15191511

申请日：2016-06-23

Applicant: Nitto Denko Corporation

Inventor： Roger Adami ,  Hao Bai ,  John Gaudette ,  Bharat Majeti ,  Seiji Nukui ,  Kwok Yin Tsang ,  Hai Wang ,  Haiqing Yin ,  Wenbin Ying

IPC: A61K47/16 ,  A61K31/17 ,  A61K47/18 ,  C07C271/16 ,  C07D205/04 ,  A61K47/22 ,  C07D207/12 ,  C07C237/16 ,  C07D207/09 ,  C07D211/86 ,  C07D211/82 ,  C07D211/74 ,  C07F9/06 ,  A61K47/24 ,  A61K31/713 ,  C07F9/10 ,  A61K31/7105

Abstract: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

公开(公告)号：US10080737B2

公开(公告)日：2018-09-25

申请号：US14679404

申请日：2015-04-06

Applicant: Nitto Denko Corporation

Inventor： Wenbin Ying ,  Kwok Yin Tsang ,  Hao Bai ,  Haiqing Yin ,  Jihua Liu ,  Li Wang

IPC: A61K47/48 ,  A61K31/337 ,  A61K31/395 ,  C08G69/48 ,  C08G69/10 ,  A61K47/64

CPC classification number: A61K31/395 ,  A61K31/337 ,  A61K47/645 ,  C08G69/10 ,  C08G69/48

Abstract: Polymer conjugates characterized in that the backbone of the polymer is an anionic polymer and hydrophobic moieties are covalently attached to the polymer backbone are useful for preparing drug encapsulated polymer hydrotropes and compositions. Such materials are useful in methods for delivering the drug into cells, and for the treatment and alleviation of diseases and disorders such as cancer.

公开(公告)号：US20180235995A1

公开(公告)日：2018-08-23

申请号：US15551270

申请日：2016-02-18

Applicant: Wenbin Ying ,  Nitto Denko Corporation

Inventor： Wenbin Ying ,  Bharat Majeti ,  Jens Harborth ,  Roger Adami

IPC: A61K31/713 ,  A61K9/00 ,  A61K9/127 ,  A61P31/14

CPC classification number: A61K31/713 ,  A61K9/0019 ,  A61K9/1271 ,  A61P31/14 ,  C12N15/1131 ,  C12N2310/14

Abstract: This invention provides methods and compositions for inhibiting Ebola virus and Ebola infection utilizing gene silencing siRNAs. The siRNAs can be targeted to one or more Ebola genes including NP, VP30, VP35, L polymerase, glycoprotein (GP), VP24, VP40, and intergenic overlapping regions selected from NP/VP35, VP35/VP40, GP/VP30, and VP24/L. A composition containing the siRNAs can be administered in a delivery vehicle such as liposomes.