公开(公告)号：WO2007131055A2

公开(公告)日：2007-11-15

申请号：PCT/US2007/068061

申请日：2007-05-02

Applicant: OCELA TECHNOLOGIES

Inventor： HEANUE, John, F. ,  HEANUE, Joseph, A. ,  WILFLEY, Brian, P. ,  LOWELL, Augustus, P.

IPC: G01N33/543 ,  C12M3/00

CPC classification number: G01N21/6408 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/415 ,  A61B5/418 ,  A61B5/6848 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/4406 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A system and method for measuring fluorescence lifetimes utilizing a light source modulated with a code sequence to interrogate a sample of interest. The system is useful for studying the interaction of chemicals, biomolecules, and other substances. The fluorescence lifetime is used as an indicator of chemical binding and chemical environment. A system and method for measuring photons. The system produces an estimate of the distribution of flight times for photons traveling from the source to the detector. A system and method for optical lymph node mapping. A correlation of a photo-detector signal and a digital code sequence, used to modulated light signal, is calculated to produce an estimate of the distribution of flight times for photons traveling from a given source to a given detector. These distributions are used along with the measured amplitudes to reconstruct a map of contrast agent location within the tissue.

Abstract translation: 一种利用利用代码序列调制的光源来测量荧光寿命的系统和方法来询问感兴趣的样品。 该系统可用于研究化学物质，生物分子和其他物质的相互作用。 荧光寿命用作化学结合和化学环境的指标。 用于测量光子的系统和方法。 该系统产生从源到检测器的光子的飞行时间分布的估计。 一种用于光学淋巴结图谱的系统和方法。 计算用于调制光信号的光检测器信号和数字码序列的相关性，以产生从给定源到给定检测器的光子的飞行时间分布的估计。 这些分布与测量的幅度一起使用以重建组织内造影剂位置的图。