公开(公告)号：US20180118648A1

公开(公告)日：2018-05-03

申请号：US15560868

申请日：2016-02-01

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Fujie TANAKA ,  Dongxin ZHANG

IPC: C07C49/753 ,  C07C49/747 ,  C07C49/255 ,  C07C69/738 ,  C07C227/10 ,  C07C227/30 ,  C07C227/42 ,  C07C229/34 ,  C07D333/22 ,  C07D333/24

CPC classification number: C07C49/753 ,  A61K31/02 ,  A61K31/045 ,  C07C49/255 ,  C07C49/747 ,  C07C69/738 ,  C07C227/10 ,  C07C227/30 ,  C07C227/34 ,  C07C227/42 ,  C07C229/34 ,  C07C2601/10 ,  C07C2601/16 ,  C07D333/22 ,  C07D333/24

Abstract: The present invention relates to novel tertiary alcohol derivatives substituted with aryl and trifluoromethyl, and optical isomers thereof. In addition, the present invention also relates to methods for the preparation and use as enantiomer recognition agent thereof. The present invention provides pharmaceutical composition and use as therapeutically active substance thereof.