公开(公告)号：US20150231222A1

公开(公告)日：2015-08-20

申请号：US14667560

申请日：2015-03-24

Applicant: ONCOTHERAPY SCIENCE, INC.

Inventor： Tomoaki FUJIOKA ,  Yusuke NAKAMURA ,  Takuya TSUNODA ,  Ryuji OSAWA ,  Midori SHIDA

IPC: A61K39/00

CPC classification number: A61K39/0011 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/54 ,  A61K2039/55566 ,  A61K2039/57 ,  A61K2039/572 ,  C07K7/06 ,  C07K14/4703

Abstract: The present invention provides peptides having an amino acid sequence as set forth in SEQ ID NO: 7, 8, 9, 10, 11, 12, 192, 195, 197, 209, 225, 226, 228, 230, 240, 241, 243, 244, 249, 253, 254 or 255, as well as peptides having the above-mentioned amino acid sequences in which 1, 2, or several amino acids are substituted, deleted, or added, wherein the peptides possess cytotoxic T cell inducibility. The present invention also provides drugs for treating or preventing a disease associated with the over-expression of MPHOSPH1 and/or DEPDC1, e.g. cancers, containing these peptides as an active ingredient. The peptides of the present invention can also be used as vaccines.

Abstract translation: 本发明提供具有如SEQ ID NO：7,8,9,10,11,12,192,195,197,209,225,226,228,230,240,241,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,29,2 243,244,249,253,254或255，以及具有上述氨基酸序列的肽，其中1,2或几个氨基酸被取代，缺失或加入，其中肽具有细胞毒性T细胞诱导性 。 本发明还提供用于治疗或预防与MPHOSPH1和/或DEPDC1的过度表达相关的疾病的药物，例如， 含有这些肽作为活性成分的癌症。 本发明的肽也可以用作疫苗。