公开(公告)号：US20200155596A1

公开(公告)日：2020-05-21

申请号：US16773487

申请日：2020-01-27

Applicant: ONCOTHERAPY SCIENCE, INC.

Inventor： Takuya TSUNODA ,  Ryuji OSAWA ,  Sachiko YAMASHITA ,  Tomohisa WATANABE ,  Tetsuro HIKICHI

IPC: A61K35/14 ,  C12N15/09 ,  C12N5/10 ,  C07K7/08 ,  C07K7/06 ,  C07K16/18 ,  A61K48/00 ,  A61K39/00 ,  A61K35/12

Abstract: The present invention provides KOC1-derived epitope peptides having the ability to induce cytotoxic T cells. The present invention further provides polynucleotides encoding the peptides, antigen-presenting cells presenting the peptides, and cytotoxic T cells targeting the peptides, as well as methods of inducing the antigen-presenting cells or CTLs. The present invention also provides compositions and pharmaceutical compositions containing them as an active ingredient. Further, the present invention provides methods of treating and/or preventing cancer, and/or preventing postoperative recurrence thereof, using the peptides, polynucleotides, antigen-presenting cells, cytotoxic T cells or pharmaceutical compositions of the present invention. Methods of inducing an immune response against cancer are also provided.

公开(公告)号：US20180346512A1

公开(公告)日：2018-12-06

申请号：US15762436

申请日：2016-10-06

Applicant: OncoTherapy Science, Inc.

Inventor： Sachiko YAMASHITA ,  Tetsuro Hikichi

IPC: C07K7/06 ,  C07K16/30 ,  G01N33/50 ,  A61K35/17 ,  A61K35/15

CPC classification number: A61K35/12 ,  A61K35/17 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4705 ,  C07K16/32 ,  C12N5/10 ,  G01N33/505

Abstract: The present invention provides FOXM1-derived epitope peptides having the ability to induce cytotoxic T cells. The present invention further provides polynucleotides encoding the peptides, antigen-presenting cells presenting the peptides, and cytotoxic T cells targeting the peptides, as well as methods of inducing the antigen-presenting cells or CTLs. The present invention also provides compositions and pharmaceutical compositions containing them as an active ingredient. Further, the present invention provides methods of treating and/or preventing cancer, and/or preventing postoperative recurrence thereof, using the peptides, polynucleotides, antigen-presenting cells, cytotoxic T cells or pharmaceutical compositions of the present invention. Methods of inducing an immune response against cancer are also provided.

公开(公告)号：US20180222941A1

公开(公告)日：2018-08-09

申请号：US15751406

申请日：2016-08-10

Applicant: OncoTherapy Science, Inc.

Inventor： Sachiko YAMASHITA ,  Tetsuro HIKICHI

IPC: C07K7/06 ,  A61P35/00 ,  C12N5/0783 ,  C07K16/18

Abstract: The present invention provides DEPDC1-derived epitope peptides having the ability to induce cytotoxic T cells. The present invention further provides polynucleotides encoding the peptides, antigen-presenting cells presenting the peptides, and cytotoxic T cells targeting the peptides, as well as methods of inducing the antigen-presenting cells or CTLs. The present invention also provides compositions and pharmaceutical compositions containing them as an active ingredient. Further, the present invention provides methods of treating and/or preventing cancer, and/or preventing postoperative recurrence thereof, using the peptides, polynucleotides, antigen-presenting cells, cytotoxic T cells or pharmaceutical compositions of the present invention. Methods of inducing an immune response against cancer are also provided.

公开(公告)号：US20220112241A1

公开(公告)日：2022-04-14

申请号：US17559991

申请日：2021-12-22

Applicant: OncoTherapy Science, Inc.

Inventor： Sachiko YAMASHITA ,  Tetsuro Hikichi

IPC: C07K7/06 ,  A61K35/12 ,  A61K35/17 ,  C12N5/10 ,  A61K35/15 ,  C07K16/32 ,  A61K38/00 ,  C07K16/30 ,  G01N33/50 ,  C07K14/47 ,  A61K39/00

Abstract: The present invention provides FOXM1-derived epitope peptides having the ability to induce cytotoxic T cells. The present invention further provides polynucleotides encoding the peptides, antigen-presenting cells presenting the peptides, and cytotoxic T cells targeting the peptides, as well as methods of inducing the antigen-presenting cells or CTLs. The present invention also provides compositions and pharmaceutical compositions containing them as an active ingredient. Further, the present invention provides methods of treating and/or preventing cancer, and/or preventing postoperative recurrence thereof, using the peptides, polynucleotides, antigen-presenting cells, cytotoxic T cells or pharmaceutical compositions of the present invention. Methods of inducing an immune response against cancer are also provided.

公开(公告)号：US20180362581A1

公开(公告)日：2018-12-20

申请号：US15762480

申请日：2016-10-06

Applicant: OncoTherapy Science, Inc.

Inventor： Sachiko YAMASHITA ,  Tetsuro HIKICHI

IPC: C07K7/06 ,  C12N5/0783 ,  C07K16/18 ,  G01N33/50 ,  A61K35/15 ,  A61K35/17

Abstract: The present invention provides MPHOSPH1-derived epitope peptides having the ability to induce cytotoxic T cells. The present invention further provides polynucleotides encoding the peptides, antigen-presenting cells presenting the peptides, and cytotoxic T cells targeting the peptides, as well as methods of inducing the antigen-presenting cells or CTLs. The present invention also provides compositions and pharmaceutical compositions containing them as an active ingredient. Further, the present invention provides methods of treating and/or preventing cancer, and/or preventing postoperative recurrence thereof, using the peptides, polynucleotides, antigen-presenting cells, cytotoxic T cells or pharmaceutical compositions of the present invention. Methods of inducing an immune response against cancer are also provided.