公开(公告)号：US11079386B2

公开(公告)日：2021-08-03

申请号：US16336846

申请日：2017-10-04

Applicant: ONCOTHERAPY SCIENCE, INC.

Inventor： Yosuke Harada ,  Tatsuki Yokoseki ,  Yusuke Nakamura

IPC: G01N33/574 ,  C07K16/28

Abstract: The present invention relates to monoclonal antibodies against FZD10. Furthermore, the present invention provides methods for diagnosing FZD10-related diseases using such an antibody, methods for detecting a FZD10 protein, methods for determining drug efficacy after treatment with FZD10 inhibitors, and methods of screening for subjects in whom treatment with FZD10 inhibitors is highly effective, and provides diagnostic reagents containing such an antibody.

公开(公告)号：US11066477B2

公开(公告)日：2021-07-20

申请号：US16328259

申请日：2017-08-25

Applicant: ONCOTHERAPY SCIENCE, INC.

Inventor： Yosuke Harada ,  Suyoun Chung ,  Yusuke Nakamura

IPC: A61K39/00 ,  C07K16/30 ,  G01N33/573 ,  G01N33/574 ,  C07K16/18 ,  C12N15/85

Abstract: The present invention relates to monoclonal antibodies against MELK. Furthermore, the present invention provides methods for diagnosing MELK-associated diseases using the antibodies, methods for detecting the MELK protein, methods for determining the drug efficacy following treatment with a MELK inhibitor, methods of screening for subjects to whom a MELK inhibitor has a high therapeutic effect, and diagnostic reagents containing the antibodies.