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    METHOD FOR DETERMINING ANALYTE CONCENTRATION USING PERIODIC TEMPERATURE MODULATION AND PHASE DETECTION
    4.
    发明申请
    METHOD FOR DETERMINING ANALYTE CONCENTRATION USING PERIODIC TEMPERATURE MODULATION AND PHASE DETECTION 审中-公开
    使用周期温度调节和相位检测确定分析浓度的方法

    公开(公告)号：WO0053086A9

    公开(公告)日：2001-10-25

    申请号：PCT/US0006348

    申请日：2000-03-10

    Applicant: OPTISCAN BIOMEDICAL CORP

    Inventor： BRAIG JAMES R ,  KRAMER CHARLES E ,  STERLING BERNHARD B ,  GOLDBERGER DANIEL S ,  ZHENG PENG ,  SHULENBERGER ARTHUR M ,  TREBINO RICK ,  KING RICHARD A ,  BARNES CASPER W

    IPC: A61B5/00 ,  G01N21/35

    CPC classification number: A61B5/0059 ,  G01N21/35

    Abstract: A method of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample (102). Infrared radiation detectors measure radiation at selected analyte absorption peak, and reference wavelengths (104). Reference, and analyte signals are detected. In the presence of the selected analyte, parameter differences between reference, and analytical signals are detectable. These parameter differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample (106). Accuracy is enhanced by inducing a periodically modulated temperature gradient in the test sample. The analytical, the reference signals may be measured continuously, and the parameter difference integrated over the measurement period to determine analyte concentration.

    Abstract translation: 描述了确定测试样品的分析物浓度的方法。 在测试样品（102）中引入温度梯度。 红外辐射探测器测量所选分析物吸收峰的辐射和参考波长（104）。 检测参考和分析物信号。 在所选分析物的存在下，参考和分析信号之间的参数差异是可检测的。 测量，相关和处理与分析物浓度有关系的这些参数差异，以确定测试样品（106）中的分析物浓度。 通过在测试样品中诱导周期调制的温度梯度来提高精度。 分析时，可以连续测量参考信号，并在测量周期内积分参数差，以确定分析物浓度。

    ANALYTE DETECTION SYSTEM AND METHOD WITH REDUCED SAMPLE VOLUME
    5.
    发明专利
    ANALYTE DETECTION SYSTEM AND METHOD WITH REDUCED SAMPLE VOLUME 未知

    公开(公告)号：CA2597610A1

    公开(公告)日：2009-08-24

    申请号：CA2597610

    申请日：2006-02-13

    Applicant: OPTISCAN BIOMEDICAL CORP

    Inventor： RULE PETER ,  KEENAN RICHARD ,  WECHSLER MARK ,  ZHENG PENG ,  STERLING BERNHARD B ,  GABLE JENNIFER H ,  BRAIG JAMES R

    IPC: A61B5/15 ,  A61M5/172

    Abstract: Described is a method of sampling a body fluid of a patient. The method includes providing a fluid handling system having one or more fluid passageways (20). The method further includes infusing an infusion fluid by way of a fluid handling system into a patient through one or more fluid passageways. The method further includes obtaining a sample of body fluid by way of a fluid handling system from a patient through one or more fluid passageways. The obtained sample is no more than 400 microliters in volume. The method further includes analyzing at least an analyzed portion of the obtained sample by way of an analyte detection system (324) operatively associated with the fluid handling system to determine a concentration of at least one analyte. A corresponding system is also disclosed.

    METHOD AND APPARATUS FOR DETECTION OF MULTIPLE ANALYTES
    9.
    发明专利
    METHOD AND APPARATUS FOR DETECTION OF MULTIPLE ANALYTES 未知

    公开(公告)号：CA2597618C

    公开(公告)日：2017-01-10

    申请号：CA2597618

    申请日：2006-02-13

    Applicant: OPTISCAN BIOMEDICAL CORP

    Inventor： STERLING BERNHARD B ,  HALL W DALE ,  CALLICOAT DAVID N ,  GABLE JENNIFER H ,  BRAIG JAMES R ,  WITTE KENNETH G ,  WECHSLER MARK ,  ZHENG PENG ,  RULE PETER ,  KEENAN RICHARD ,  KING RICHARD A

    IPC: A61B5/15

    Abstract: An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and at least one pump intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer positioned to analyze at least a portion of the sample and measure the presence of two or more analytes. Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample. Disclosed are further means for separating plasma and serum and a spectroscopic analyzer.

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    10.
    发明专利
    "Method and apparatus for detection of multiple analytes" 未知

    公开(公告)号：AU2012200332B2

    公开(公告)日：2014-07-10

    申请号：AU2012200332

    申请日：2012-01-19

    Applicant: OPTISCAN BIOMEDICAL CORP

    Inventor： STERLING BERNHARD B ,  CALLICOAT DAVID N ,  BRAIG JAMES R ,  GABLE JENNIFER H ,  WITTE KENNETH G ,  HALL W DALE ,  ZHENG PENG ,  RULE PETER ,  KEENAN RICHARD ,  KING RICHARD A ,  WECHSLER MARK

    IPC: A61B5/15

    Abstract: C:WRPonbrDCC\MASW9569 LDOC-I/IK/2012 An apparatus (10) for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end (11) configured to maintain 5 fluid communication with a bodily fluid in a patient and at least one pump (203) intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer (140) positioned to analyze at least a portion of the sample and measure the presence of two or more analytes. Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a 10 sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample. Disclosed are further means for separating plasma and serum and a spectroscopic analyzer. -0

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