公开(公告)号：EP3359149A1

公开(公告)日：2018-08-15

申请号：EP16854292.6

申请日：2016-10-06

Applicant: Ora, Inc.

Inventor： ABELSON, Mark, B. ,  CORCORAN, Peter ,  LANE, Keith

IPC: A61K31/381 ,  C07D333/02

CPC classification number: A61K31/381 ,  A61K9/0048 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention provides methods of treating or preventing an ocular disease or disorder in a subject, methods of treating or preventing ocular pain or discomfort comprising, administering to the subject a composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a transient receptor potential melastatin 8 (TRPM8) antagonist. In certain preferred embodiments, the ocular disease or disorder is a dry eye disease.

公开(公告)号：WO2017062570A1

公开(公告)日：2017-04-13

申请号：PCT/US2016/055677

申请日：2016-10-06

Applicant: ORA, INC.

Inventor： ABELSON, Mark, B. ,  CORCORAN, Peter ,  LANE, Keith

IPC: A61K31/381 ,  C07D333/02

CPC classification number: A61K31/381 ,  A61K9/0048 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention provides methods of treating or preventing an ocular disease or disorder in a subject, methods of treating or preventing ocular pain or discomfort comprising, administering to the subject a composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a transient receptor potential melastatin 8 (TRPM8) antagonist. In certain preferred embodiments, the ocular disease or disorder is a dry eye disease.

Abstract translation: 本发明提供了治疗或预防受试者眼部疾病或病症的方法，治疗或预防眼部疼痛或不适的方法，其包括向所述受试者施用包含药学上可接受的载体和药学有效量的瞬时受体潜在的melastatin 8（TRPM8）拮抗剂。 在某些优选实施方案中，眼部疾病或病症是干眼病。