公开(公告)号：JP2000344736A

公开(公告)日：2000-12-12

申请号：JP2000114168

申请日：2000-04-14

Applicant: OREAL

Inventor： MAIGNAN JEAN ,  GENARD SYLVIE ,  SERGE MICHEL

IPC: C07D263/10 ,  A61K8/00 ,  A61K8/04 ,  A61K8/30 ,  A61K8/46 ,  A61K8/49 ,  A61K31/10 ,  A61K31/19 ,  A61K31/215 ,  A61K31/41 ,  A61K31/421 ,  A61P17/00 ,  A61P17/04 ,  A61P17/06 ,  A61P17/08 ,  A61P17/12 ,  A61P17/16 ,  A61P35/00 ,  A61Q19/00 ,  C07C319/00 ,  C07C323/05 ,  C07C323/12 ,  C07C323/52 ,  C07D257/04 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain a (poly)thiaalkyne (acid) type compound which has an activity related to the transactivation of a PPAR type receptor, especially a PPAR-α-subtype receptor and is preferably useful for treating inflammatory diseases such as rheumatic arteritis, lupus and psoriasis. SOLUTION: A compound of the formula: R1-Y-CH2-C≡C-CH2-S-CH2-R2 Y is S(0)t [(t) is 0 to 2], CH2, C≡C or C=C; R1 is a (halogenated) 1 to 18C alkyl, a 1 to 18C alkenyl, a 1 to 18C alkynyl or the like; R2 is tetrazolyl of formula I, nitrile, oxazolinyl of formula II or the like} and its derivative. For example, 3,8-dithia-5-hexadecynic acid. The compound of the formula wherein Y is methylene or a triple bond is obtained, for example, by reacting a compound of the formula: R1-X with sodium acetylide and then reacting the obtained compound of the formula: R1-C≡C-H as a starting raw material. When added to a cosmetic composition, the compound is preferably added in a concentration of 0.0001 to 3 wt.%.

公开(公告)号：WO2004084854A8

公开(公告)日：2005-01-20

申请号：PCT/EP2004004018

申请日：2004-03-24

Applicant: OREAL ,  MAIGNAN JEAN

Inventor： MAIGNAN JEAN

IPC: A61K8/365 ,  A61Q5/08 ,  A61Q19/02 ,  A61K7/48

CPC classification number: A61K8/365 ,  A61Q5/08 ,  A61Q19/02

Abstract: The subject of the present invention is the cosmetic or dermatological use of at least one compound of formula (I ) in a composition, as agent for removing brownish pigmented spots, senescence spots, and/or as antibronzing agent for the skin. The subject of the invention is also a cosmetic method for removing brownish pigmented spots and/or senescence spots, and/or a cosmetic method for lightening bronzed skin, comprising the application to the skin, of a cosmetic composition containing a compound of formula (I) defined above.

Abstract translation: 本发明的主题是至少一种式（I）化合物在组合物中的化妆品或皮肤病学用途，作为去除褐色色素斑点，衰老斑点和/或作为皮肤抗纤维化剂的试剂。 本发明的主题也是一种化妆品组合物，其中所述化妆品组合物含有式（I）化合物或其组合物，其中所述化妆品组合物含有式 ）。

公开(公告)号：WO0145663A3

公开(公告)日：2002-05-16

申请号：PCT/FR0003645

申请日：2000-12-21

Applicant: OREAL ,  MAIGNAN JEAN ,  MICHEL SERGE

Inventor： MAIGNAN JEAN ,  MICHEL SERGE

IPC: C07D311/04 ,  A61K8/00 ,  A61K8/30 ,  A61K8/36 ,  A61K8/368 ,  A61K8/49 ,  A61K8/92 ,  A61K31/192 ,  A61K31/195 ,  A61K31/353 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P17/00 ,  A61P17/02 ,  A61P25/00 ,  A61P37/02 ,  A61P37/04 ,  A61P43/00 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/06 ,  A61Q19/08 ,  A61K7/48

CPC classification number: A61K31/195 ,  A61K8/368 ,  A61K31/192 ,  A61K2800/70 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/06 ,  A61Q19/08

Abstract: The invention relates to the use of compounds of formula (I), in particular as activators of PPARs-type receptors, for producing a composition for treating skin disorders such as rosacea, intrinsic (or chronological) ageing, pigmentation disorders, disorders of the sebaceous function, disorders of the barrier function and especially, epidermal lipid secretion disorders, scarring disorders, skin atrophies caused by corticosteroids or ulcers, immune system disorders, cardiovascular disorders and/or lipid metabolism disorders.

Abstract translation: 本发明涉及式（I）化合物，特别是作为PPARs型受体的激活剂的用途，用于生产用于治疗皮肤病症如红斑痤疮，内在（或时间性）衰老，色素沉着病症，皮脂病 功能障碍，特别是表皮脂质分泌障碍，瘢痕形成障碍，由皮质类固醇或溃疡引起的皮肤萎缩，免疫系统疾病，心血管疾病和/或脂质代谢紊乱。

公开(公告)号：JP2001253820A

公开(公告)日：2001-09-18

申请号：JP2000384570

申请日：2000-12-19

Applicant: OREAL

Inventor： MAIGNAN JEAN

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/33 ,  A61K8/34 ,  A61K31/047 ,  A61K31/05 ,  A61P17/16 ,  A61Q3/00 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/00 ,  A61K7/06 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain a medicament having properties to reduce or inhibit protein glycation phenomena, in particular the glycation of the skin and/or protein of the structure concomitant therewith. SOLUTION: In order to reduce or inhibit the glycation of protein, an effective quantity of 3,3',5,5'-tetrahydroxystilbene or a derivative thereof is used as a medicament or composition.

公开(公告)号：JP2000119147A

公开(公告)日：2000-04-25

申请号：JP24807299

申请日：1999-09-01

Applicant: OREAL

Inventor： BAUDRY RICHARD ,  MAIGNAN JEAN ,  GENARD SYLVIE

IPC: A61K8/00 ,  A61K8/49 ,  A61Q5/06 ,  A61Q5/10 ,  C07D215/24 ,  C07D401/04 ,  C07D403/04 ,  A61K7/13 ,  C09B57/00 ,  C09B67/42

Abstract: PROBLEM TO BE SOLVED: To prepare dyestuff meeting the requirements of dyeing having rich and varied color tone and capable of satisfying a prescriber by including a specific compound. SOLUTION: This dyestuff is a stain for keratin substances such as human keratin fibers and includes a compound of formula I or III wherein, Q is expressed by formula II [wherein, R1-R4 are each H, a 1-4C alkoxy, a (substituted)(1-4C)alkyl or the like; W3 and W4 are each H, hydroxyl or a (substituted)(1-4C)alkyl] or the like; X is CH or N; T is H, a halogen or hydroxyl}, [e.g. 6-(1-pentyl-1H-pyrrol-2-yl)quinoline-5,8-dione or the like] in a content of ca. 0.01-10 wt.% (pref.ca. 0.05-5 wt.%) based on the total weight of the composition as a general rule.

公开(公告)号：JP2006225405A

公开(公告)日：2006-08-31

申请号：JP2006150237

申请日：2006-05-30

Applicant: OREAL

Inventor： MAIGNAN JEAN ,  SERGE MICHEL

IPC: A61K31/192 ,  C07D311/04 ,  A61K8/00 ,  A61K8/30 ,  A61K8/36 ,  A61K8/368 ,  A61K8/40 ,  A61K8/49 ,  A61K8/92 ,  A61K31/195 ,  A61K31/353 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P17/00 ,  A61P17/02 ,  A61P25/00 ,  A61P37/02 ,  A61P37/04 ,  A61P43/00 ,  A61Q5/00 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/06 ,  A61Q19/08

Abstract: PROBLEM TO BE SOLVED: To provide a compound for treating the pigmentation disorders of the skins and hairs. SOLUTION: The invention relates to the activators of PPARs-type receptors for treating the pigmentation disorders of the skins and hairs. The invention also relates to the use of compounds of formula (I) as activators of PPARs-type receptors for producing compositions for treating the pigmentation disorders of the skins and hairs. COPYRIGHT: (C)2006,JPO&NCIPI

公开(公告)号：JP2000136109A

公开(公告)日：2000-05-16

申请号：JP26952499

申请日：1999-09-22

Applicant: OREAL

Inventor： MAIGNAN JEAN ,  GENARD SYLVIE

IPC: A61K8/30 ,  A61K8/35 ,  A61K8/36 ,  A61K8/365 ,  A61K8/37 ,  A61K8/42 ,  A61K8/44 ,  A61K31/16 ,  A61K31/19 ,  A61K31/198 ,  A61K31/20 ,  A61K31/401 ,  A61K31/405 ,  A61K31/417 ,  A61K31/7008 ,  A61K31/74 ,  A61Q19/00 ,  A61Q19/08 ,  C07C59/40 ,  C07C59/42 ,  C07C59/58 ,  C07C69/732 ,  C07C69/734 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain a medicine for facilitating the elimination of dermal rubbishes from skins and/or stimulating the regeneration of the epidermis and resisting against skin aging by including a specific compound as an active ingredient. SOLUTION: This medicine is obtained by including the effective amount (suitably a concentration in the range of 0.001-20 wt.%) of at least one of compounds corresponding to formula I [wherein R1 is H or NR'R" (wherein R' and R" are each H, a 1-4C alkyl, a 3-4C alkenyl or the like; R' and R" can form a heterocyclic ring together with nitrogen atoms combined with them) or the like; R2 is H, a 1-18C alkyl, a perfluoroalkyl, a 2-18C alkenyl or the like] or its salts, isomers and stereoisomers. Further, for example, the compound of formula I may be prepared from ethyl-10-[(tetrahydro-2H-pyran-2-yl)oxy]-2- decenoate represented by formula II.

公开(公告)号：FR2648131A1

公开(公告)日：1990-12-14

申请号：FR8907805

申请日：1989-06-13

Applicant: OREAL ,  OREAL

Inventor： MAIGNAN JEAN ,  JEAN MAIGNAN ,  MALLE GERARD ,  GERARD MALLE ,  DEFLANDRE ANDRE ,  ANDRE DEFLANDRE ,  LANG GERARD ,  GERARD LANG

IPC: A61K8/30 ,  A61K8/33 ,  A61K8/34 ,  A61K8/41 ,  A61K8/92 ,  A61K31/05 ,  A61K31/045 ,  A61K31/085 ,  A61K31/12 ,  A61K31/135 ,  A61K31/19 ,  A61K31/215 ,  A61K47/10 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/08 ,  A61Q17/00 ,  C07C37/06 ,  C07C39/08 ,  C07C39/17 ,  C07C41/26 ,  C07C41/30 ,  C07C43/21 ,  C07C43/23 ,  C07C45/27 ,  C07C45/46 ,  C07C45/68 ,  C07C49/83 ,  C07C49/84 ,  C07C50/10 ,  C07C65/17 ,  C07C65/26 ,  C09K15/08

Abstract: Dérivés de tétrahydro-5,6,7,8 naphtalénol-1. Ces dérivés répondent à la formule générale suivante : (CF DESSIN DANS BOPI) dans laquelle : R1 , R2 , R3 , R4 , R5 et R6 représentent un atome d'hydrogène ou un radical alkyle inférieur, R représente un atome d'hydrogène, un radical alkyle en C1 -C1 8 , un radical alkyle en C2 -C1 8 substitué par un ou plusieurs hydroxyle(s), un radical alkényle en C3 -C1 8 , un radical acyle en C2 -C1 8 , un radical benzyle, un radical benzoyle, un radical carboxyle et les sels carboxyliques d'un métal alcalin ou alcalino-terreux ou d'une amine organique. Ces dérivés trouvent une application en tant qu'agents antioxydants dans des compositions cosmétiques et dans des compositions pharmaceutiques pour le traitement préventif d'inflammations et allergies cutanées ou de certaines formes de cancers.

公开(公告)号：DE60031791D1

公开(公告)日：2006-12-21

申请号：DE60031791

申请日：2000-12-21

Applicant: OREAL

Inventor： MAIGNAN JEAN ,  MICHEL SERGE

IPC: A61K8/368 ,  C07D311/04 ,  A61K8/00 ,  A61K8/30 ,  A61K8/36 ,  A61K8/49 ,  A61K8/92 ,  A61K31/192 ,  A61K31/195 ,  A61K31/353 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P17/00 ,  A61P17/02 ,  A61P25/00 ,  A61P37/02 ,  A61P37/04 ,  A61P43/00 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/06 ,  A61Q19/08

Abstract: Compounds of formula (I): characteristically activators of receptors of PPAR type, are well suited for treating cutaneous disorders/afflictions, notably rosacea, intrinsic (or chronological) aging, pigmentation disorders, seborrhoeic function disorders, barrier function disorders and more particularly epidermal lipid secretion disorders, wound healing disorders, corticosteroid-induced cutaneous atrophies, or ulcers, immune system disorders, cardiovascular system conditions, and/or lipid metabolism disorders.

公开(公告)号：AT344655T

公开(公告)日：2006-11-15

申请号：AT00993481

申请日：2000-12-21

Applicant: OREAL

Inventor： MAIGNAN JEAN ,  MICHEL SERGE

IPC: C07D311/04 ,  A61K8/00 ,  A61K8/30 ,  A61K8/36 ,  A61K8/368 ,  A61K8/49 ,  A61K8/92 ,  A61K31/192 ,  A61K31/195 ,  A61K31/353 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P17/00 ,  A61P17/02 ,  A61P25/00 ,  A61P37/02 ,  A61P37/04 ,  A61P43/00 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/06 ,  A61Q19/08

Abstract: Compounds of formula (I): characteristically activators of receptors of PPAR type, are well suited for treating cutaneous disorders/afflictions, notably rosacea, intrinsic (or chronological) aging, pigmentation disorders, seborrhoeic function disorders, barrier function disorders and more particularly epidermal lipid secretion disorders, wound healing disorders, corticosteroid-induced cutaneous atrophies, or ulcers, immune system disorders, cardiovascular system conditions, and/or lipid metabolism disorders.