公开(公告)号：AU2590292A

公开(公告)日：1993-04-05

申请号：AU2590292

申请日：1992-09-09

Applicant: OREGON GRADUATE INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： DAVID H THOMPSON ,  VALERIE C ANDERSON

IPC: A61K9/127 ,  A61K41/00 ,  A61K47/24 ,  B01J13/02

Abstract: A triggered release liposomal delivery system is disclosed that selectively releases its contents in response to illumination or reduction in pH. The liposomes contain an amphipathic lipid, such as a phospholipid, having two chains derived from fatty acid that allow the lipid to pack into a bilayer structure. One or both of the alkyl chains contains a vinyl ether functionality that is cleaved by reactive oxygen species (ROS) or acid. A photosensitizer is incorporated into the liposomal cavity or membrane, and produces ROS or acid when illuminated to cleave the vinyl ether functionality and disrupt the liposomal membrane to release the vesicle contents. The lipid is preferably a plasmalogen, for example (* CHEMICAL STRUCTURE *) wherein R1 and R2 are each long chain hydrocarbons containing 12-24 carbons.