公开(公告)号：AU2002239965B2

公开(公告)日：2007-01-04

申请号：AU2002239965

申请日：2002-01-17

Applicant: ORTHOLOGIC CORP

Inventor： CROWTHER ROGER S ,  YANG JINPING ,  STIERNBERG JANET ,  SIMMONS DAVID J ,  CARNEY DARRELL H ,  BERGMANN JOHN ,  REDIN WILLIAM R

IPC: A61K47/04 ,  A61K9/50 ,  A61K35/12 ,  A61K35/32 ,  A61K38/46 ,  A61K38/48 ,  A61K47/18 ,  A61K47/34 ,  A61K47/42 ,  A61L27/12 ,  A61L27/18 ,  A61L27/22 ,  A61L27/38 ,  A61L27/46 ,  A61L27/50 ,  A61P19/00 ,  A61P19/08 ,  C12N5/077

公开(公告)号：AU2001273561B2

公开(公告)日：2004-10-28

申请号：AU2001273561

申请日：2001-07-19

Applicant: ORTHOLOGIC CORP

Inventor： CROWTHER ROGER S ,  CARNEY DARRELL H ,  BERGMANN JOHN ,  STIERNBERG JANET

IPC: C12N9/74 ,  A61K35/32 ,  A61K38/00 ,  A61K38/17 ,  A61K38/46 ,  A61K38/48 ,  A61K45/00 ,  A61K47/34 ,  A61L27/00 ,  A61L27/18 ,  A61L27/22 ,  A61L27/54 ,  A61P17/02 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P43/00 ,  C12N5/06

Abstract: Disclosed is a method of stimulating cartilage growth, repair or regeneration at a site in a subject in need of such growth, repair or regeneration. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site. Also disclosed is a method of stimulating the proliferation and expansion of chrondrocytes in vitro. The method comprises culturing chrondrocytes in the presence of a stimulating amount of an NPAR agonist.