公开(公告)号：AT362939T

公开(公告)日：2007-06-15

申请号：AT03763062

申请日：2003-07-01

Applicant: ORTHOLOGIC CORP

Inventor： CARNEY DARRELL

IPC: C07K5/00 ,  A61K38/00 ,  A61K38/16 ,  C07K5/10 ,  C12N9/74

Abstract: Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val (SEQ ID NO:2), or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO:2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.