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    Method to use fibroblast or supernatant from fibroblast for immune response inhibition in transplantation, and composition of the same
    1.
    发明专利
    Method to use fibroblast or supernatant from fibroblast for immune response inhibition in transplantation, and composition of the same 审中-公开
    使用FIBROBLAST或来自FIBROBLAST的免疫调节免疫反应抑制方法及其组合

    公开(公告)号：JP2011037865A

    公开(公告)日：2011-02-24

    申请号：JP2010213040

    申请日：2010-09-24

    Applicant: Osiris Therapeutics Inc ,  オシリス セラピューティクス,インコーポレイテッド

    Inventor： MC INTOSH KEVIN R ,  MOSCA JOSEPH D ,  KLYUSHNENKOVA ELENA N

    IPC: A61K35/12 ,  A61K45/00 ,  A61K35/14 ,  A61K35/28 ,  A61K35/36 ,  A61P37/06 ,  C12N5/071

    CPC classification number: A61K35/33

    Abstract: PROBLEM TO BE SOLVED: To provide a method and a composition for immune response inhibition in transplantation.
    SOLUTION: The method is one method to induce so as to reduce an immune response in a recipient by treating the recipient with a quantity of a fibroblast or a supernatant from a fibroblast culture substance effective to reduce or inhibit host rejection of a transplant. The fibroblast or the supernatant from the fibroblast culture substance is administered before, at the same time as, or after the transplantation. The method is effective in reducing the immune response to the transplant without compromising the immune response to other external antigen. Furthermore, a method to induce reducing the immune response against a host by external tissue, that is, graft versus host disease is disclosed.
    COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 待解决的问题：提供移植中免疫应答抑制的方法和组合物。 解决方案：该方法是通过用有效减少或抑制移植物宿主排斥的成纤维细胞培养物质的成纤维细胞或上清液处理受体而诱导接受者免疫应答的一种方法 。 来自成纤维细胞培养物质的成纤维细胞或上清液在移植之前，同时或之后施用。 该方法在减少对移植物的免疫应答而不损害对其它外部抗原的免疫应答方面是有效的。 此外，公开了一种通过外部组织诱导降低针对宿主的免疫应答的方法，即移植物抗宿主病。 版权所有（C）2011，JPO＆INPIT

    USES FOR HUMANE NON-AUTOLOGOUS MESENCHYMAL STEM CELLS
    4.
    发明申请
    USES FOR HUMANE NON-AUTOLOGOUS MESENCHYMAL STEM CELLS 审中-公开
    用于人类非自体神经干细胞

    公开(公告)号：WO9946366A8

    公开(公告)日：2001-02-15

    申请号：PCT/US9905351

    申请日：1999-03-12

    Applicant: OSIRIS THERAPEUTICS INC ,  BRUDER SCOTT P ,  MCINTOSH KEVIN R ,  MARSHAK DANIEL R ,  MOSCA JOSEPH D

    Inventor： BRUDER SCOTT P ,  MCINTOSH KEVIN R ,  MARSHAK DANIEL R ,  MOSCA JOSEPH D

    IPC: A61K35/12 ,  A61K35/28 ,  A61K48/00 ,  A61L27/00 ,  A61P19/08 ,  A61P43/00 ,  C12N5/0775 ,  C12N5/06

    CPC classification number: C12N5/0663 ,  A61K48/00 ,  A61K2035/124

    Abstract: Methods and devices using non-autologous mesenchymal stem cells comprising treating a recipient in need thereof with an effective amount of non-autologous mesenchymal stem cells, including methods and preparations for treating and regenerating connective tissue and enhancing bone marrow engraftment in an individual; and for using genetically engineered allogeneic human mesenchymal stem cells that carry within them genes of interest particularly for the expression of physiologically or pharmacologically active proteins in gene therapy for correction of genetic disorders or "rebuilding" proteins important in tissue repair.

    Abstract translation: 包括使用非自体间充质干细胞的方法和装置，包括用有效量的非自体间充质干细胞治疗有需要的受体，包括用于治疗和再生结缔组织并增强个体中骨髓移植的方法和制剂; 并且使用遗传工程化的同种异体人间充质干细胞，其携带其中感兴趣的基因，特别是用于在用于基因治疗中表达生理学或药理学活性蛋白质的基因治疗中用于校正组织修复中重要的遗传疾病或“重建”蛋白质。

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