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    METHOD OF PERFORMING A PLURALITY OF SYNTHESIS PROCESSES OF PREPARING A RADIOPHARMACEUTICAL IN SERIES, A DEVICE AND CASSETTE FOR PERFORMING THIS METHOD
    1.
    发明申请
    METHOD OF PERFORMING A PLURALITY OF SYNTHESIS PROCESSES OF PREPARING A RADIOPHARMACEUTICAL IN SERIES, A DEVICE AND CASSETTE FOR PERFORMING THIS METHOD 审中-公开
    在系列中制备无线电波的合成方法的多重方法，用于实施该方法的装置和方法

    公开(公告)号：WO2016184980A1

    公开(公告)日：2016-11-24

    申请号：PCT/EP2016/061319

    申请日：2016-05-19

    Applicant: OUT AND OUT CHEMISTRY S.P.R.L.

    Inventor： TADINO, Vincent Luc Antoine ,  VILLERET, Guillaume, André, René

    IPC: C07B59/00

    CPC classification number: C07H5/02 ,  B01J19/24 ,  B01J41/00 ,  B01J2219/24 ,  C01D3/02 ,  C07B59/00 ,  C07C39/40 ,  C07C53/18 ,  C07C215/40 ,  C07C229/36 ,  C07C2603/40 ,  C07D207/46 ,  C07D233/91 ,  C07H19/06

    Abstract: The invention relates to a method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, which method comprises carrying out a first synthesis run comprising the steps of: a) providing water containing 18F; b) trapping the 18F from the water provided in step a) on an anion exchange material (18); c) eluting the trapped 18F from the anion exchange material (18) to a reaction vessel (58) of first radiopharmaceutical synthesis cassette (50'); d) preparing a radiopharmaceutical incorporating the eluted 18F using the first radiopharmaceutical synthesis cassette (50'); wherein steps a)-d) are repeated in at least one subsequent run using another radiopharmaceutical synthesis cassette (50"; 50"'); and wherein the method comprises a reconditioning step of said anion exchange material (18) between two consecutive runs Other aspects of the invention relate to a device for performing this method, and a cassette for use in the device.

    Abstract translation: 本发明涉及一种串联制备放射性药物的多种合成方法，该方法包括进行第一合成步骤，包括以下步骤：a）提供含18F的水; b）将18F从步骤a）中提供的水中捕获到阴离子交换材料（18）上; c）将截留的18F从阴离子交换材料（18）洗脱到第一放射性药物合成盒（50'）的反应容器（58）; d）使用第一放射性药物合成盒（50'）制备并入洗脱的18F的放射性药物; 其中步骤a）-d）在使用另一放射性药物合成盒（50“; 50”）的至少一个后续运行中重复; 并且其中所述方法包括在两个连续行程之间的所述阴离子交换材料（18）的修复步骤。本发明的其它方面涉及用于执行该方法的装置和用于该装置的盒。

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