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公开(公告)号：ES2673269T3
公开(公告)日：2018-06-21
申请号：ES09164430
申请日：2009-07-02
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： COWLEY AARON BLAKE , GÖLANDER CARL-GUSTAF , LI QINGSHAN , SIDHU HARMEET
IPC: C12N9/02 , A61K9/16 , A61K38/00 , A61K38/44 , A61K38/45 , A61K38/51 , C12N9/10 , C12N9/88 , C12P21/02
Abstract: Un método para aislar una proteína recombinante que es insoluble en el citoplasma de una célula hospedadora y que no se halla como un cuerpo de inclusión, que comprende, a) separar dicha proteína recombinante insoluble de las proteínas solubles de la célula hospedadora; y b) solubilizar la proteína recombinante separada mediante el uso de un ligando de unión de proteínas seleccionado del grupo que consiste en arginina, Tris, Mn2+, Mg2+ y Ca2+, en el que la proteína recombinante es el mutante C383S, C383A de la proteína oxalato descarboxilasa (OxDC) de tipo natural según SEQ. ID Nº. 1 o SEQ. ID Nº. 2, o la proteína OxDC codificada por una secuencia seleccionada de SEQ. ID Nº. 3, SEQ. ID Nº. 4, SEQ. ID Nº. 5, SEQ. ID Nº. 6, SEQ. ID Nº. 7, SEQ. ID Nº. 8, SEQ. ID Nº. 15, SEQ. ID Nº. 16, SEQ. ID Nº. 17, SEQ. ID Nº. 18, o SEQ. ID Nº. 19.
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公开(公告)号：PL2449098T3
公开(公告)日：2017-06-30
申请号：PL10744865
申请日：2010-07-01
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： SIDHU HARMEET , LI QINGSHAN , COWLEY AARON BLAKE , GÖLANDER CARL-GUSTAF
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公开(公告)号：DK2270138T3
公开(公告)日：2018-06-25
申请号：DK09164430
申请日：2009-07-02
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： COWLEY AARON BLAKE , GÖLANDER CARL-GUSTAF , LI QINGSHAN , SIDHU HARMEET
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公开(公告)号：LT2449098T
公开(公告)日：2017-05-25
申请号：LT10744865
申请日：2010-07-01
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： SIDHU HARMEET , LI QINGSHAN , COWLEY AARON BLAKE , GÖLANDER CARL-GUSTAF
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公开(公告)号：CA3012811A1
公开(公告)日：2011-01-06
申请号：CA3012811
申请日：2010-07-01
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： SIDHU HARMEET , LI QINGSHAN , COWLEY AARON BLAKE , GOLANDER CARL-GUSTAF
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, and methods for the purification and isolation of recombinant oxalate reducing enzyme proteins. The invention provides methods and compositions for the delivery of oxalate-reducing enzymes in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions.
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Patent Agency Ranking
公开(公告)号：CA2767039C
公开(公告)日：2018-09-04
申请号：CA2767039
申请日：2010-07-01
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： SIDHU HARMEET , LI QINGSHAN , COWLEY AARON BLAKE , GOELANDER CAROL-GUSTAF
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, and methods for the purification and isolation of recombinant oxalate reducing enzyme proteins. The invention provides methods and compositions for the delivery of oxalate-reducing enzymes in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions.
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公开(公告)号：CA2767039A1
公开(公告)日：2011-01-06
申请号：CA2767039
申请日：2010-07-01
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： SIDHU HARMEET , LI QINGSHAN , COWLEY AARON BLAKE , GOELANDER CAROL-GUSTAF
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, and methods for the purification and isolation of recombinant oxalate reducing enzyme proteins. The invention provides methods and compositions for the delivery of oxalate-reducing enzymes in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions.
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公开(公告)号：HUE030905T2
公开(公告)日：2017-06-28
申请号：HUE10744865
申请日：2010-07-01
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： SIDHU HARMEET , LI QINGSHAN , COWLEY AARON BLAKE , GOELANDER CARL-GUSTAF
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公开(公告)号：DK2449098T3
公开(公告)日：2017-03-06
申请号：DK10744865
申请日：2010-07-01
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： SIDHU HARMEET , LI QINGSHAN , COWLEY AARON BLAKE , GÖLANDER CARL-GUSTAF
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公开(公告)号：HK1210805A1
公开(公告)日：2016-05-06
申请号：HK15111425
申请日：2015-11-19
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： SIDHU HARMEET , LI QINGSHAN , COWLEY AARON BLAKE , GOLANDER CARL-GUSTAF
IPC: C12N20060101 , A61K20060101 , A61P20060101
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, and methods for the purification and isolation of recombinant oxalate reducing enzyme proteins. The invention provides methods and compositions for the delivery of oxalate-reducing enzymes in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions.
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