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公开(公告)号：US10568946B2
公开(公告)日：2020-02-25
申请号：US15809885
申请日：2017-11-10
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： Harmeet Sidhu , Aaron Blake Cowley , Carl-Gustaf Golander , Qingshan Li
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, and methods for the purification and isolation of recombinant oxalate reducing enzyme proteins. The invention provides methods and compositions for the delivery of oxalate-reducing enzymes in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions.
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2.发明授权公开(公告)号：US08940295B2
公开(公告)日：2015-01-27
申请号：US13851594
申请日：2013-03-27
Applicant: Oxthera Intellectual Property AB
Inventor： Harmeet Sidhu , Aaron Blake Cowley , Carl-Gustaf Golander , Qingshan Li
IPC: A61K38/00 , A61K38/54 , A61K38/44 , C12N9/88 , C12N9/10 , C12N9/06 , C07H21/04 , A61K38/51 , A61K9/16
CPC classification number: A61K38/51 , A61K9/1635 , A61K9/1682 , C12N9/88 , C12Y401/01002
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, and methods for the purification and isolation of recombinant oxalate reducing enzyme proteins. The invention provides methods and compositions for the delivery of oxalate-reducing enzymes in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions.
Abstract translation: 本发明包括用于还原人中草酸盐的方法和组合物，以及用于纯化和分离重组草酸盐还原酶蛋白质的方法。 本发明提供了用于在颗粒组合物中递送草酸盐还原酶的方法和组合物。 本发明的组合物适用于治疗或预防草酸盐相关病症的方法。
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公开(公告)号：US20190091268A1
公开(公告)日：2019-03-28
申请号：US16134793
申请日：2018-09-18
Inventor： Harmeet Sidhu , Milton J. Allison
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, animals and plants. For example, the invention provides methods and compositions for the delivery of one ore more oxalate-reducing enzymes to the intestinal tracts of persons and animals. The methods and compositions can be used in treating and preventing oxalate-related conditions.
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公开(公告)号：US20180169196A1
公开(公告)日：2018-06-21
申请号：US15809885
申请日：2017-11-10
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： Harmeet Sidhu , Aaron Blake Cowley , Carl-Gustaf Golander , Qingshan Li
CPC classification number: A61K38/51 , A61K9/1635 , A61K9/1682 , C12N9/88 , C12Y401/01002
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, and methods for the purification and isolation of recombinant oxalate reducing enzyme proteins. The invention provides methods and compositions for the delivery of oxalate-reducing enzymes in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions.
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公开(公告)号：US10653726B2
公开(公告)日：2020-05-19
申请号：US16134793
申请日：2018-09-18
Inventor： Harmeet Sidhu , Milton J. Allison
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, animals and plants. For example, the invention provides methods and compositions for the delivery of one ore more oxalate-reducing enzymes to the intestinal tracts of persons and animals. The methods and compositions can be used in treating and preventing oxalate-related conditions.
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Patent Agency Ranking
公开(公告)号：US10149866B2
公开(公告)日：2018-12-11
申请号：US13919266
申请日：2013-06-17
Inventor： Harmeet Sidhu , Milton J. Allison
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, animals and plants. For example, the invention provides methods and compositions for the delivery of one or more oxalate-reducing enzymes to the intestinal tracts of persons and animals. The methods and compositions can be used in treating and preventing oxalate-related conditions.
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公开(公告)号：US20130216515A1
公开(公告)日：2013-08-22
申请号：US13851594
申请日：2013-03-27
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： Harmeet Sidhu , Aaron Blake Cowley , Carl-Gustaf Golander , Qingshan Li
IPC: A61K38/51
CPC classification number: A61K38/51 , A61K9/1635 , A61K9/1682 , C12N9/88 , C12Y401/01002
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, and methods for the purification and isolation of recombinant oxalate reducing enzyme proteins. The invention provides methods and compositions for the delivery of oxalate-reducing enzymes in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions.
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公开(公告)号：US10272043B2
公开(公告)日：2019-04-30
申请号：US14524361
申请日：2014-10-27
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： Qingshan Li , Harmeet Sidhu
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans. For example, the invention provides methods and compositions for the delivery of one or more oxalate-reducing enzymes embedded in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions including, but not limited to, hyperoxaluria, absorptive hyperoxaluria, enteric hyperoxaluria, primary hyperoxaluria, idiopathic calcium oxalate kidney stone disease (urolithiasis), vulvodynia, oxalosis associated with end-stage renal disease, cardiac conductance disorders, inflammatory bowel disease, Crohn's disease, ulcerative colitis, and patients who have undergone gastrointestinal surgery and bariatric surgery (surgery for obesity), and/or who have undergone antibiotic treatment.
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公开(公告)号：US09833499B2
公开(公告)日：2017-12-05
申请号：US14569077
申请日：2014-12-12
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： Harmeet Sidhu , Aaron Blake Cowley , Carl-Gustaf Golander , Qingshan Li
IPC: A61K38/00 , A61K38/54 , A61K38/44 , C12N9/88 , C12N9/10 , C12N9/06 , C07H21/04 , A61K38/51 , A61K9/16
CPC classification number: A61K38/51 , A61K9/1635 , A61K9/1682 , C12N9/88 , C12Y401/01002
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans, and methods for the purification and isolation of recombinant oxalate reducing enzyme proteins. The invention provides methods and compositions for the delivery of oxalate-reducing enzymes in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions.
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公开(公告)号：US20150125538A1
公开(公告)日：2015-05-07
申请号：US14524361
申请日：2014-10-27
Applicant: OXTHERA INTELLECTUAL PROPERTY AB
Inventor： Qingshan Li , Harmeet Sidhu
CPC classification number: A61K9/1652 , A61K9/5036 , A61K9/5073 , A61K9/5089 , A61K9/5115 , A61K9/5161 , A61K9/5192 , A61K38/44 , A61K38/45 , A61K38/488 , A61K38/51 , A61K47/36 , C12Y102/03004 , C12Y208/03016 , C12Y304/23002 , C12Y401/01002 , C12Y401/01008 , A61K2300/00
Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans. For example, the invention provides methods and compositions for the delivery of one or more oxalate-reducing enzymes embedded in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions including, but not limited to, hyperoxaluria, absorptive hyperoxaluria, enteric hyperoxaluria, primary hyperoxaluria, idiopathic calcium oxalate kidney stone disease (urolithiasis), vulvodynia, oxalosis associated with end-stage renal disease, cardiac conductance disorders, inflammatory bowel disease, Crohn's disease, ulcerative colitis, and patients who have undergone gastrointestinal surgery and bariatric surgery (surgery for obesity), and/or who have undergone antibiotic treatment.
Abstract translation: 本发明包括用于还原人类中草酸盐的方法和组合物。 例如，本发明提供了用于递送一种或多种包含在颗粒组合物中的草酸盐还原酶的方法和组合物。 本发明的组合物适用于治疗或预防草酸盐相关病症的方法，包括但不限于高氧尿症，吸收性高氧尿症，肠高氧尿症，原发性高过氧化尿症，特发性草酸钙肾结石病（尿路结石），外阴，草酸病 与终末期肾脏疾病，心脏电导障碍，炎症性肠病，克罗恩病，溃疡性结肠炎以及经历胃肠外科手术和减肥手术（肥胖手术）的患者和/或已进行抗生素治疗的患者相关。
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