公开(公告)号：US20170368105A1

公开(公告)日：2017-12-28

申请号：US15631707

申请日：2017-06-23

Applicant: Osiris Therapeutics, Inc.

Inventor： Steven Michael Sinclair ,  Alla Danilkovitch ,  Malathi Sathyamoorthy ,  Jin-Qiang Kuang ,  Sandeep Dhall ,  Yishan Liu ,  Anthony John Melchiorri ,  Matthew Robert Moorman ,  Mena Schiano Lo Moriello ,  Anne Allgood Lerch

IPC: A61K35/50 ,  A61K35/51

CPC classification number: A61K35/50 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K9/19 ,  A61K35/33 ,  A61K35/51 ,  A61L26/0057 ,  A61L27/3604 ,  A61L27/3834 ,  A61P17/02 ,  A61P19/00 ,  A61P19/02 ,  A61P19/04 ,  A61P19/10 ,  A61P29/00

Abstract: Disclosed are compositions comprising a non-homogenized chorionic matrix, a homogenized amniotic matrix and a homogenized UC (UC) matrix, wherein the non-homogenized chorionic matrix comprises viable cells. Disclosed are methods of making the compositions disclosed herein comprising preparing a non-homogenized chorionic matrix, preparing a homogenized amniotic matrix, preparing a homogenized UC matrix, and combining the non-homogenized chorionic matrix, the non-homogenized chorionic matrix, and the homogenized UC matrix. Disclosed are methods of treating a tissue injury or chronic pain comprising administering any of the disclosed compositions to an area of a subject comprising a tissue injury.

公开(公告)号：US11318168B2

公开(公告)日：2022-05-03

申请号：US15631707

申请日：2017-06-23

Applicant: Osiris Therapeutics, Inc.

Inventor： Steven Michael Sinclair ,  Alla Danilkovitch ,  Malathi Sathyamoorthy ,  Jin-Qiang Kuang ,  Sandeep Dhall ,  Yishan Liu ,  Anthony John Melchiorri ,  Matthew Robert Moorman ,  Mena Schiano Lo Moriello ,  Anne Allgood Lerch

IPC: A61K35/50 ,  A61K35/51 ,  A01N1/02 ,  A61K9/00 ,  A61K9/06 ,  A61K9/19 ,  A61K35/33 ,  A61P19/00 ,  A61P19/04 ,  A61P17/02 ,  A61P29/00 ,  A61P19/10 ,  A61P19/02 ,  A61L27/36 ,  A61L27/38 ,  A61L26/00

Abstract: Disclosed are compositions comprising a non-homogenized chorionic matrix, a homogenized amniotic matrix and a homogenized UC (UC) matrix, wherein the non-homogenized chorionic matrix comprises viable cells. Disclosed are methods of making the compositions disclosed herein comprising preparing a non-homogenized chorionic matrix, preparing a homogenized amniotic matrix, preparing a homogenized UC matrix, and combining the non-homogenized chorionic matrix, the non-homogenized chorionic matrix, and the homogenized UC matrix. Disclosed are methods of treating a tissue injury or chronic pain comprising administering any of the disclosed compositions to an area of a subject comprising a tissue injury.

公开(公告)号：US20200171096A1

公开(公告)日：2020-06-04

申请号：US16694650

申请日：2019-11-25

Applicant: Osiris Therapeutics, Inc.

Inventor： Steven Michael Sinclair ,  Alla Danilkovitch ,  Malathi Sathyamoorthy ,  Jin-Qiang Kuang ,  Sandeep Dhall ,  Anthony John Melchiorri

IPC: A61K35/50 ,  A61K35/36 ,  A61K35/32 ,  A61K9/19 ,  A61K9/16 ,  A61L27/36 ,  A61F13/00 ,  A01N1/02

Abstract: Disclosed are methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are lyophilized tissues prepared using the disclosed methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are methods of treating a wound or tissue defect comprising administering a reconstituted lyophilized tissue to the wound or tissue defect.

公开(公告)号：US20180104282A1

公开(公告)日：2018-04-19

申请号：US15632142

申请日：2017-06-23

Applicant: Osiris Therapeutics, Inc.

Inventor： Steven Michael Sinclair ,  Alla Danilkovitch ,  Malathi Sathyamoorthy ,  Jin-Qiang Kuang ,  Sandeep Dhall ,  Anthony John Melchiorri

IPC: A61K35/50 ,  A61K35/36 ,  A61K35/32 ,  A61K9/19 ,  A61K9/16

CPC classification number: A61K35/50 ,  A01N1/0221 ,  A01N1/0284 ,  A61F13/00 ,  A61K9/1682 ,  A61K9/19 ,  A61K35/32 ,  A61K35/36 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/362 ,  A61L27/3691

Abstract: Disclosed are methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are lyophilized tissues prepared using the disclosed methods of lyophilizing a tissue sample comprising obtaining a tissue sample, contacting the tissue sample with a lyoprotectant solution, freezing the tissue sample, performing a first drying step of the tissue sample after freezing, and performing a second drying step of the tissue sample after the first drying step. Disclosed are methods of treating a wound or tissue defect comprising administering a reconstituted lyophilized tissue to the wound or tissue defect.