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公开(公告)号：WO2006083751A2
公开(公告)日：2006-08-10
申请号：PCT/US2006003157
申请日：2006-01-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , TURNER STEPHEN W
Inventor： TURNER STEPHEN W
IPC: G01N31/00
CPC classification number: B82Y30/00 , B01L3/5085 , B01L2200/0668 , B01L2300/0819 , B01L2400/0454 , C12Q1/6869 , C12Q1/6874 , G02B6/02 , C12Q2525/186 , C12Q2523/319
Abstract: The present invention relates to the uses of reversible extension terminator in conjunction with optical confinements in nucleic acid sequencing. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost nucleic acid sequencing.
Abstract translation: 本发明涉及可逆延伸终止剂与核酸测序中的光学限制的用途。 本发明中体现的装置和方法对于高通量和低成本核酸测序特别有用。
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公开(公告)号：WO2008121374A4
公开(公告)日：2009-01-15
申请号：PCT/US2008004148
申请日：2008-03-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , KORLACH JONAS , SAMIEE KEVAN , TURNER STEPHEN W , FREUDENTHAL JAKE
Inventor： KORLACH JONAS , SAMIEE KEVAN , TURNER STEPHEN W , FREUDENTHAL JAKE
CPC classification number: G01N21/6452 , G01N21/648
Abstract: Composition, systems, apparatus and methods of enhancing fluorescent signals in biochemical are described. Metal particle proximity to enzymes that produce fluorescent products provide enhanced fluorescence of the product and plasmon resonance of the metal particle. Multi-labeled nucleotides enhance signal production. Reflectance of illumination light and emitted fluorescence increase signal strength for a given illumination light.
Abstract translation: 描述了增强生物化学荧光信号的组成，系统，装置和方法。 与产生荧光产物的酶接近的金属颗粒提供产物的增强的荧光和金属颗粒的等离子体共振。 多标记核苷酸增强信号产生。 照明光的反射和发出的荧光增加给定照明光的信号强度。
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公开(公告)号：WO2008121374A3
公开(公告)日：2008-12-04
申请号：PCT/US2008004148
申请日：2008-03-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , KORLACH JONAS , SAMIEE KEVAN , TURNER STEPHEN W , FREUDENTHAL JAKE
Inventor： KORLACH JONAS , SAMIEE KEVAN , TURNER STEPHEN W , FREUDENTHAL JAKE
CPC classification number: G01N21/6452 , G01N21/648
Abstract: Composition, systems, apparatus and methods of enhancing fluorescent signals in biochemical are described. Metal particle proximity to enzymes that produce fluorescent products provide enhanced fluorescence of the product and plasmon resonance of the metal particle. Multi-labeled nucleotides enhance signal production. Reflectance of illumination light and emitted fluorescence increase signal strength for a given illumination light.
Abstract translation: 描述了增强生物化学荧光信号的组成，系统，装置和方法。 与产生荧光产物的酶接近的金属颗粒提供产物的增强的荧光和金属颗粒的等离子体共振。 多标记核苷酸增强信号产生。 照明光的反射和发出的荧光增加给定照明光的信号强度。
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公开(公告)号：CA2593855A1
公开(公告)日：2006-08-10
申请号：CA2593855
申请日：2006-01-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TURNER STEPHEN W
IPC: G01N31/00
Abstract: The present invention relates to the uses of reversible extension terminator in conjunction with optical confinements in nucleic acid sequencing. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost nucleic acid sequencing.
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Patent Agency Ranking
公开(公告)号：CA2579150A1
公开(公告)日：2006-04-27
申请号：CA2579150
申请日：2005-09-16
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： KORLACH JONAS , TURNER STEPHEN W
IPC: H05H3/04
Abstract: The present invention relates to optical confinements, method of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.
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公开(公告)号：CA2579150C
公开(公告)日：2014-11-25
申请号：CA2579150
申请日：2005-09-16
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TURNER STEPHEN W , KORLACH JONAS
IPC: C12Q1/68 , B82Y5/00 , B82Y15/00 , B82Y20/00 , C12M1/40 , C40B60/00 , G01N21/00 , G01N21/75 , G02B6/12
Abstract: The present invention relates to optical confinements, method of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.
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公开(公告)号：AU2006211150A1
公开(公告)日：2006-08-10
申请号：AU2006211150
申请日：2006-01-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： TURNER STEPHEN W
IPC: G01N31/00
Abstract: The present invention relates to the uses of reversible extension terminator in conjunction with optical confinements in nucleic acid sequencing. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost nucleic acid sequencing.
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公开(公告)号：EP1844328A4
公开(公告)日：2009-09-16
申请号：EP06719837
申请日：2006-01-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TURNER STEPHEN W
IPC: C12Q1/68
CPC classification number: B82Y30/00 , B01L3/5085 , B01L2200/0668 , B01L2300/0819 , B01L2400/0454 , C12Q1/6869 , C12Q1/6874 , G02B6/02 , C12Q2525/186 , C12Q2523/319
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公开(公告)号：EP2134871A4
公开(公告)日：2010-05-26
申请号：EP08742395
申请日：2008-03-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： KORLACH JONAS , SAMIEE KEVAN , TURNER STEPHEN W , FREUDENTHAL JAKE
CPC classification number: G01N21/6452 , G01N21/648
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