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公开(公告)号：WO1996010645A1
公开(公告)日：1996-04-11
申请号：PCT/US1995012642
申请日：1995-10-02
Applicant: PATHOGENESIS CORPORATION
Inventor： PATHOGENESIS CORPORATION , STOVER, Kendall , HICKEY, Mark, J.
IPC: C12Q01/66
CPC classification number: C12N9/0069 , C12N15/74 , C12Q1/02 , C12Q1/6897
Abstract: This invention relates to a method of quantifying bacteria in vivo or in vitro using bacterial reporter strains. In particular this invention provides a method utilizing mycobacterial reporter strains that permits rapid screening for in vivo antimycobacterial activity of various compositions. In addition this invention provides for particular mycobacterial reporter strains expressing the FFlux gene at levels sufficiently high to allow detection in tissue homogenates without lysis or concentration of the bacteria.
Abstract translation: 本发明涉及使用细菌报道菌株在体内或体外定量细菌的方法。 特别地，本发明提供了利用分枝杆菌报道菌株的方法，其允许快速筛选各种组合物的体内抗分枝杆菌活性。 此外，本发明提供了表达FFlux基因的特异性分枝杆菌报道菌株，其水平足够高以允许在组织匀浆中检测而不裂解或浓缩细菌。
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公开(公告)号：EP0784700A1
公开(公告)日：1997-07-23
申请号：EP95935267.0
申请日：1995-10-02
Applicant: PATHOGENESIS CORPORATION
Inventor： STOVER, Kendall , HICKEY, Mark Jeffrey
CPC classification number: C12N9/0069 , C12N15/74 , C12Q1/02 , C12Q1/6897
Abstract: This invention relates to a method of quantifying bacteria in vivo or in vitro using bacterial reporter strains. In particular this invention provides a method utilizing mycobacterial reporter strains that permits rapid screening for in vivo antimycobacterial activity of various compositions. In addition this invention provides for particular mycobacterial reporter strains expressing the FFlux gene at levels sufficiently high to allow detection in tissue homogenates without lysis or concentration of the bacteria.
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