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1.发明申请
公开(公告)号：WO1998020836A3
公开(公告)日：1998-05-22
申请号：PCT/US1997021829
申请日：1997-11-13
Applicant: PATHOGENESIS CORPORATION
IPC: A61K38/00
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2.发明授权PURE BIOLOGICALLY ACTIVE COLISTIN, ITS COMPONENTS AND A COLISTIN FORMULATION FOR TREATMENT OF PULMONARY INFECTIONS 失效PURE，有机活性粘菌素，及其部件和多黏菌素制剂炎症呼吸的治疗
公开(公告)号：EP0920324B1
公开(公告)日：2001-06-27
申请号：EP97954029.1
申请日：1997-11-13
Applicant: PATHOGENESIS CORPORATION
Inventor： VanDEVANTER, Donald, R. , MONTGOMERY, Alan, B.
CPC classification number: A61K9/0078 , A61K38/12 , C07K7/62
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3.发明公开PURE BIOLOGICALLY ACTIVE COLISTIN, ITS COMPONENTS AND A COLISTIN FORMULATION FOR TREATMENT OF PULMONARY INFECTIONS 失效PURE，有机活性粘菌素，及其部件和多黏菌素制剂炎症呼吸的治疗
公开(公告)号：EP0920324A2
公开(公告)日：1999-06-09
申请号：EP97954029.0
申请日：1997-11-13
Applicant: PATHOGENESIS CORPORATION
Inventor： VanDEVANTER, Donald, R. , MONTGOMERY, Alan, B.
CPC classification number: A61K9/0078 , A61K38/12 , C07K7/62
Abstract: An anti-Pseudomonas aeruginosa agent which is substantially pure biologically active colistin component, a mixture thereof or a pharmaceutically acceptable salt thereof delivered as an aerosol or dry powder formulation. The figure shows a general structure of a prodrug colimycin (Figure 1A) and a generic formula of a drug colistin and its components substituents (Figure 1B). A formulation and method for preparation of substantially pure biologically active colistin component, a mixture thereof or a pharmaceutically acceptable salt thereof. A method for treatment and prophylaxis of Pseudomonas aeruginosa, Stenotrophomonas maltophilia or other susceptible pulmonary bacterial infections.
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