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    GASTRAL RETENTION SYSTEM FOR GRADUAL RELEASE OF DRUG
    1.
    发明专利
    GASTRAL RETENTION SYSTEM FOR GRADUAL RELEASE OF DRUG 失效

    公开(公告)号：JPH0229268A

    公开(公告)日：1990-01-31

    申请号：JP13899889

    申请日：1989-05-31

    Applicant: PFIZER

    Inventor： CURATOLO WILLIAM JOHN ,  LO JEELIN

    IPC: A61K9/00 ,  A61K9/20 ,  A61K9/22 ,  A61M31/00

    Abstract: PURPOSE: To retard movement of oral medicine in the stomach and intestines by releasing system for the said medicine consisting of a device to release it slowly equipped with discontinuous compression element; to resist movement of the medicine as for dilatation type by a device to retain it in the stomach which is effectively maintained therein, and that if the contour of the device is changed, the medicine will be released and separated from the stomach to be dissolved. CONSTITUTION: Total capacity in an oral administration system is determined according to anatomy or physiology on mammals for oral medicine to be given. As to the use for human beings, the maximum dimensions of the system at the time of dilatation are, from practical point of view, 2.5cm to 6.0cm, preferably 3.0cm to 5.0cm. The system herein referred to has a various range of contours partially measured according to that of the said releasing device. In the case of the system except for sphere or circle, minimum and maximum dimensions of the dilatation type are 2.5cm and 6.0cm respectively. Major factors to sustain the distribution system mentioned herein in digestive tract are overall dimensions (length and width), contour and hardness of arm.

    GASTRIC RETENTION SYSTEM FOR CONTROLLED DRUG RELEASE
    3.
    发明专利
    GASTRIC RETENTION SYSTEM FOR CONTROLLED DRUG RELEASE 未知

    公开(公告)号：CA1335351C

    公开(公告)日：1995-04-25

    申请号：CA601034

    申请日：1989-05-29

    Applicant: PFIZER

    Inventor： CURATOLO WILLIAM J ,  LO JEELIN

    IPC: A61K9/00 ,  A61K9/20 ,  A61K9/22 ,  A61M31/00

    Abstract: An oral drug delivery system having delayed gastrointestinal transit comprising a non-continuous compressible element and an attached controlled release device and which in the expanded form resists gastrointestinal transit; and a modular system for use therein comprising a non-continuous compressible element and an attached receptacle means for receiving and holding a drug-containing orally administrable controlled release device and which in the expanded form resists gastric transit.

    4.
    发明专利
    未知

    公开(公告)号：AT101328T

    公开(公告)日：1994-02-15

    申请号：AT89302428

    申请日：1989-03-13

    Applicant: PFIZER

    Inventor： LO JEELIN ,  CURTISS ALAN CLARKSON

    IPC: A61J3/00 ,  A61D7/00 ,  A61K9/00 ,  A61K9/22 ,  A61K31/505 ,  A61M31/00 ,  A61P33/00

    Abstract: A method for enhancing the unrolling of an active agent-containing matrix device, including a laminate device, in an aqueous use environment, said device being constrained in a rolled configuration prior to placement in said environment, comprising coating one side of the device with an elastomer prior to constraining it in a rolled configuration; and the devices so treated.

    5.
    发明专利
    未知

    公开(公告)号：DE68904596D1

    公开(公告)日：1993-03-11

    申请号：DE68904596

    申请日：1989-05-15

    Applicant: PFIZER

    Inventor： CURATOLO WILLIAM JOHN ,  LO JEELIN

    IPC: A61K9/00 ,  A61K9/20 ,  A61K9/22 ,  A61M31/00

    Abstract: An oral drug delivery system having delayed gastrointestinal transit comprising a non-continuous compressible element and an attached controlled release device and which in the expanded form resists gastrointestinal transit; and a modular system for use therein comprising a non-continuous compressible element and an attached receptacle means for receiving and holding a drug-containing orally administrable controlled release device and which in the expanded form resists gastric transit.

    10.
    发明专利
    未知

    公开(公告)号：BR8901280A

    公开(公告)日：1989-11-07

    申请号：BR8901280

    申请日：1989-03-20

    Applicant: PFIZER

    Inventor： LO JEELIN ,  CURTISS ALAN CLARKSON

    IPC: A61J3/00 ,  A61D7/00 ,  A61K9/00 ,  A61K9/22 ,  A61K31/505 ,  A61M31/00 ,  A61P33/00 ,  B05D3/02 ,  B32B27/18

    Abstract: A method for enhancing the unrolling of an active agent-containing matrix device, including a laminate device, in an aqueous use environment, said device being constrained in a rolled configuration prior to placement in said environment, comprising coating one side of the device with an elastomer prior to constraining it in a rolled configuration; and the devices so treated.

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