中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

104 records (took 0.024 seconds)

    4.
    发明专利
    未知

    公开(公告)号：PT89195B

    公开(公告)日：1993-06-30

    申请号：PT8919588

    申请日：1988-12-09

    Applicant: PFIZER LTD

    Inventor： RAY STEPHEN JAMES ,  RICHARDSON KENNETH

    IPC: A01N43/653 ,  A01N43/74 ,  A01N43/76 ,  A01N43/78 ,  C07D249/08 ,  A01N43/84 ,  A61K31/41 ,  A61K31/50 ,  A61K31/535 ,  A61K31/54 ,  A61P31/04 ,  C07D249/14 ,  C07D401/12 ,  C07D403/06 ,  C07D413/12 ,  C07D417/12 ,  C07D521/00 ,  C07D417/14 ,  C07D413/14 ,  C07D401/14

    Abstract: An antifungal agent of the formula:- where R is a phenyl group optionally substituted by 1 to 3 substituents each independently selected from halo and CF3; R is either (a) a phenyl group substituted by a group of the formula -N=CH-N(C1-C4 alkyl)2, or (b) a 5- or 6-membered aromatic heterocyclic group which is optionally benzo-fused and optionally substituted by 1 or 2 substituents each independently selected from halo, C1-C4 alkyl and halo-(C1 or C2 alkyl), said heterocyclic group being attached to the nitrogen atom of the piperazine ring by a carbon atom; and R is H or CH3; or an O-ester or O-ether thereof which is a C2-C4 alkanoyl or benzoyl ester, or a C1-C4 alkyl, C2-C4 alkenyl, phenyl-(C1-C4 alkyl) or phenyl ether, said phenyl and benzoyl groups of said O-esters and O-ethers being optionally substituted by one or two substituetns each selected from C1-C4 alkyl, halo and halo-(C1 or C2 alkyl); or a pharmaceutically acceptable salt thereof.

    6.
    发明专利
    未知

    公开(公告)号：PT85607B

    公开(公告)日：1990-05-31

    申请号：PT8560787

    申请日：1987-08-27

    Applicant: PFIZER LTD

    Inventor： CROSS PETER EDWARD ,  RICHARDSON KENNETH ,  COOPER KELVIN ,  PARRY MICHAEL JOHN

    IPC: A61K31/44 ,  A61K31/455 ,  A61P37/08 ,  C07D211/90 ,  C07D277/46 ,  C07D285/12 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D521/00 ,  A61K31/415

    Abstract: Compounds of the formula:- wherein R is phenyl or phenyl substituted by one or more substituents selected from nitro, halo, C1-C4 alkyl, C1-C4 alkoxy, aryl(C1-C4 alkoxy), C1-C4 alkylthio, C1-C4 alkylsulphonyl, hydroxy, trifluoromethyl and cyano; R and R are each independently H or C1-C6 alkyl, or the two groups may be joined together to form with the nitrogen atom to which they are attached a pyrrolidinyl, piperidino, morpholino, piperazinyl or N-(substituted)-piperazinyl group, said substituent being C1-C4 alkyl, C2-C4 alkanoyl or pyridyl; or R is H or C1-C4 alkyl and R is C3-C7 cycloalkyl, aryl, indanyl, or heteroaryl, or a C1-C4 alkyl group substituted by one or more substituents selected from C3-C7 cycloalkyl, C1-C4 alkoxycarbonyl, aryl and heteroaryl; R is C1-C6 alkyl; Y is an alkylene group of from 2 to 8 carbon atoms which may be straight or branched-chain having at least 2 carbon atoms in the chain linking X to the oxygen atom; X is 1-imidazolyl optionally substituted with from 1 to 3 substituents which may be C1-C4 alkyl groups or halo atoms, or wherein the 4 and 5 positions may be linked by -(CH2)p- where p is 3 or 4, and their pharmaceutically acceptable salts are antagonists of PAF and are useful in the treatment of allergic, inflammatory and hypersecretory conditions.

    7.
    发明专利
    未知

    公开(公告)号：DK71789A

    公开(公告)日：1989-08-21

    申请号：DK71789

    申请日：1989-02-16

    Applicant: PFIZER LTD

    Inventor： COOPER KELVIN ,  STEELE JOHN ,  RICHARDSON KENNETH

    IPC: C07D213/82 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/53 ,  A61P29/00 ,  A61P37/08 ,  C07D401/12 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04 ,  C07D521/00

    Abstract: Compounds of the formula:- wherein R is phenyl or phenyl substituted by nitro, halo, C1-C4 alkyl, C1-C4 alkoxy, aryl(C1-C4)alkoxy, fluoro(C1-C4)alkoxy, C1-C4 alkylthio, C1-C4 alkylsulphonyl, hydroxy, trifluoromethyl or cyano; R and R are H or C1-C6 alkyl, or the two groups form a pyrrolidinyl, piperidino, morpholino, piperazinyl, N-(C1-C4 alkyl)piperazinyl or N-(C2-C4 alkanoyl)piperazinyl group; or R is H or C1-C4 alkyl and R is C3-C7 cycloalkyl, aryl, indanyl, or heteroaryl, or a C1-C4 alkyl group substituted by C3-C7 cycloalkyl, C1-C4 alkoxycarbonyl, aryl or heteroaryl; R is OH, C1-C6 alkoxy, aryl(C1-C4 alkoxy), or NR R wherein each of R and R is independently H or C1-C6 alkyl, or the two groups form a pyrrolidinyl, piperidino, morpholino, piperazinyl, or N-(C1-C4 alkyl)piperazinyl group; Y is an alkylene group of from 2 to 8 carbon atoms and X is 1,2,4-triazol-3-yl, 1,2,4-triazol-4-yl or triazolo[2,3-a]pyrid-2-yl optionally substituted by C1-C4 alkyl or phenyl; are antagonists of PAF and are useful in the treatment of allergic, inflammatory and hypersecretory conditions.

    8.
    发明专利
    未知

    公开(公告)号：DK686088A

    公开(公告)日：1989-07-21

    申请号：DK686088

    申请日：1988-12-09

    Applicant: PFIZER LTD

    Inventor： RAY STEPHEN JAMES ,  RICHARDSON KENNETH

    IPC: C07D249/08 ,  A01N43/653 ,  A01N43/74 ,  A01N43/76 ,  A01N43/78 ,  A01N43/84 ,  A61K31/41 ,  A61K31/50 ,  A61K31/535 ,  A61K31/54 ,  A61P31/04 ,  C07D249/14 ,  C07D401/12 ,  C07D403/06 ,  C07D413/12 ,  C07D417/12 ,  C07D521/00 ,  C07D403/12

    Abstract: An antifungal agent of the formula:- where R is a phenyl group optionally substituted by 1 to 3 substituents each independently selected from halo and CF3; R is either (a) a phenyl group substituted by a group of the formula -N=CH-N(C1-C4 alkyl)2, or (b) a 5- or 6-membered aromatic heterocyclic group which is optionally benzo-fused and optionally substituted by 1 or 2 substituents each independently selected from halo, C1-C4 alkyl and halo-(C1 or C2 alkyl), said heterocyclic group being attached to the nitrogen atom of the piperazine ring by a carbon atom; and R is H or CH3; or an O-ester or O-ether thereof which is a C2-C4 alkanoyl or benzoyl ester, or a C1-C4 alkyl, C2-C4 alkenyl, phenyl-(C1-C4 alkyl) or phenyl ether, said phenyl and benzoyl groups of said O-esters and O-ethers being optionally substituted by one or two substituetns each selected from C1-C4 alkyl, halo and halo-(C1 or C2 alkyl); or a pharmaceutically acceptable salt thereof.

    PROCESS FOR PRODUCING DIHYDROPYRIDINE DERIVATIVES AND PHARMACEUTICALS COMPRISING THESE COMPOUNDS AS ACTIVE INGREDIENT
    10.
    发明专利
    PROCESS FOR PRODUCING DIHYDROPYRIDINE DERIVATIVES AND PHARMACEUTICALS COMPRISING THESE COMPOUNDS AS ACTIVE INGREDIENT 未知

    公开(公告)号：HUT47933A

    公开(公告)日：1989-04-28

    申请号：HU270888

    申请日：1988-05-27

    Applicant: PFIZER LTD

    Inventor： COOPER KELVIN ,  FRAY MICHAEL J ,  RICHARDSON KENNETH

    IPC: A61K31/435 ,  A61K31/505 ,  A61K31/52 ,  A61P37/08 ,  C07D211/90 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  A61K31/395

    Abstract: Compounds of the formula:- wherein R is phenyl or phenyl substituted by nitro, halo, C1-C4 alkyl, C1-C4 alkoxy, fluoro(C1-C4)alkoxy, aryl(C1-C4)alkoxy, C1-C4 alkylthio, C1-C4 alkylsulphonyl, hydroxy, trifluoromethyl or cyano; R and R are H or C1-C6 alkyl, or the two groups form a pyrrolidinyl, piperidino, morpholino, piperazinyl, N-(C1-C4 alkyl)piperazinyl or N-(C2-C4 alkanoyl)piperazinyl group; or R is H or C1-C4 alkyl and R is C3-C7 cycloalkyl, aryl, indanyl or heteroaryl, or a C1-C4 alkyl group substituted by C3-C7 cycloalkyl, C1-C4 alkoxycarbonyl, aryl or heteroaryl; R is OH, C1-C6 alkyloxy, aryl(C1-C4 alkoxy), or NR R wherein each of R R is independently H or C1-C6 alkyl, or the two groups form a pyrrolidinyl, piperidino, morpholino, piperazinyl, or N-(C1-C4 alkyl)piperazinyl group; Y is an alkylene group of from 2 to 8 carbon atoms and X is 1-, 2- or 3-imidazopyridyl or 1-, 2- or 3-imidazopyrimidinyl optionally substituted by C1-C4 alkyl, C1-C4 alkoxy, halo, CF3 or CN; are antagonists of PAF and are useful in the treatment of allergic inflammatory and hypersecretory conditions.

Patent Agency Ranking