公开(公告)号：EP1442022A4

公开(公告)日：2005-05-04

申请号：EP02802875

申请日：2002-11-07

Applicant: PHARMACIA CORP

Inventor： PHILLION DENNIS P ,  CROWLEY KATHLEEN S ,  BASHKIN JAMES K ,  SCHWEITZER BARBARA A ,  BURNETTE BARRY L ,  WOODARD SCOTT S

IPC: C12N15/09 ,  A61K31/4025 ,  A61K31/4178 ,  A61K38/00 ,  A61K48/00 ,  A61P43/00 ,  C07D207/30 ,  C07D403/14 ,  C07K14/575 ,  C12N5/02 ,  C12N15/63

CPC classification number: C12N15/635 ,  C07K14/575

Abstract: Processes and compositions are provided for regulating COX2 gene expression in a cell. The process includes selecting a polyamide composition comprising N-methyl pyrrole (Py) and N-methyl imidazole (Im) to provide specific binding to DNA at a COX2 gene target site in a cell. The polyamide is then combined with the cell containing the COX2 gene, wherein the polyamide binds to the COX2 gene promoter target site and regulates transcription of the COX2 gene.

公开(公告)号：BR0213988A

公开(公告)日：2004-08-31

申请号：BR0213988

申请日：2002-11-07

Applicant: PHARMACIA CORP

Inventor： PHILLION DENNIS P ,  CROWLEY KATHLEEN S ,  BASHKIN JAMES K ,  SCHWEITZER BARBARA A ,  BURNETTE BARRY L ,  WOODARD SCOTT S

IPC: C12N15/09 ,  A61K31/4025 ,  A61K31/4178 ,  A61K38/00 ,  A61K48/00 ,  A61P43/00 ,  C07D207/30 ,  C07D403/14 ,  C07K14/575 ,  C12N5/02 ,  C12N15/63 ,  C07D231/02 ,  C07D403/02

公开(公告)号：AU2002356916A1

公开(公告)日：2003-05-19

申请号：AU2002356916

申请日：2002-11-07

Applicant: PHARMACIA CORP

Inventor： BASHKIN JAMES K ,  PHILLION DENNIS P ,  SCHWEITZER BARBARA A ,  WOODARD SCOTT S ,  CROWLEY KATHLEEN S ,  BURNETTE BARRY L

IPC: C12N15/09 ,  A61K31/4025 ,  A61K31/4178 ,  A61K38/00 ,  A61K48/00 ,  A61P43/00 ,  C07D207/30 ,  C07D403/14 ,  C07K14/575 ,  C12N5/02 ,  C12N15/63 ,  C07D231/02 ,  C07D403/02

公开(公告)号：CA2466391A1

公开(公告)日：2003-05-15

申请号：CA2466391

申请日：2002-11-07

Applicant: PHARMACIA CORP

Inventor： BASHKIN JAMES K ,  SCHWEITZER BARBARA A ,  CROWLEY KATHLEEN S ,  PHILLION DENNIS P ,  WOODARD SCOTT S ,  BURNETTE BARRY L

IPC: C12N15/09 ,  A61K31/4025 ,  A61K31/4178 ,  A61K38/00 ,  A61K48/00 ,  A61P43/00 ,  C07D207/30 ,  C07D403/14 ,  C07K14/575 ,  C12N5/02 ,  C12N15/63 ,  C07D231/02 ,  C07D403/02

Abstract: Processes and compositions are provided for regulating COX2 gene expression in a cell. The process includes selecting a polyamide composition comprising N- methyl pyrrole (Py) and N-methyl imidazole (Im) to provide specific binding to DNA at a COX2 gene target site in a cell. The polyamide is then combined wit h the cell containing the COX2 gene, wherein the polyamide binds to the COX2 gene promoter target site and regulates transcription of the COX2 gene.