公开(公告)号：WO2004016749A3

公开(公告)日：2004-08-26

申请号：PCT/US0325389

申请日：2003-08-14

Applicant: PHARMACIA CORP ,  ROSS STUART A

Inventor： ROSS STUART A

IPC: A61K38/00 ,  C12N15/113 ,  C07H21/02 ,  A61K48/00 ,  C07H21/04 ,  C12N15/85 ,  C12N15/86 ,  C12P19/34

CPC classification number: C12N15/1137 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y602/01003 ,  Y02P20/582 ,  C12N2310/3521 ,  C12N2310/3525

Abstract: Antisense compounds, compositions, and methods are provided for modulating the expression of acyl-Coa synthesis 1, heretofore referred to as ACS1. The compositions comprise antisense compounds, particulary antisense oligonucleotides, targeted to nucleic acids encoding ACS1. Methods of using these compounds for modulation of ACS1 expression and for treatment of diseases associated with expression of ACS1 are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节前面称为ACS1的酰基辅酶A合成的表达。 组合物包含靶向编码ACS1的核酸的反义化合物，特异性反义寡核苷酸。 提供了使用这些化合物调节ACS1表达和治疗ACS1表达相关疾病的方法。

公开(公告)号：EP1572713A4

公开(公告)日：2006-05-24

申请号：EP03751855

申请日：2003-08-14

Applicant: PHARMACIA CORP

Inventor： ROSS STUART A

IPC: A61K38/00 ,  C12N15/113 ,  C07H21/02 ,  A61K48/00 ,  C07H21/04 ,  C12N15/85 ,  C12N15/86 ,  C12P19/34

CPC classification number: C12N15/1137 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y602/01003 ,  Y02P20/582 ,  C12N2310/3521 ,  C12N2310/3525

Abstract: Antisense compounds, compositions, and methods are provided for modulating the expression of acyl-Coa synthesis 1, heretofore referred to as ACS1. The compositions comprise antisense compounds, particulary antisense oligonucleotides, targeted to nucleic acids encoding ACS1. Methods of using these compounds for modulation of ACS1 expression and for treatment of diseases associated with expression of ACS1 are provided.

公开(公告)号：AU2003269962A1

公开(公告)日：2004-03-03

申请号：AU2003269962

申请日：2003-08-14

Applicant: PHARMACIA CORP

Inventor： ROSS STUART A

IPC: A61K38/00 ,  C12N15/113

公开(公告)号：MXPA05001837A

公开(公告)日：2005-04-19

申请号：MXPA05001837

申请日：2003-08-14

Applicant: PHARMACIA CORP

Inventor： ROSS STUART A

IPC: A61K38/00 ,  C12N15/113 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/85 ,  C12N15/86 ,  C12P19/34 ,  C12N00/00

Abstract: Se proveen metodos, compuestos y composiciones de polaridad opuesta para modular la expresion de la acil-Coa sintetasa 1, denominada en la presente como ACS1; las composiciones comprenden compuestos de polaridad opuesta, en particular oligonucleotidos de polaridad opuesta, dirigidos a acidos nucleicos que codifican la ACS1, se proveen metodos para utilizar estos compuestos para la modulacion de la expresion de la ACS1 y para el tratamiento de enfermedades asociadas a la expresion de la ACS1.

公开(公告)号：BR0313550A

公开(公告)日：2006-06-13

申请号：BR0313550

申请日：2003-08-14

Applicant: PHARMACIA CORP

Inventor： ROSS STUART A

IPC: A61K38/00 ,  C12N15/113 ,  C07H21/02 ,  A61K48/00 ,  C07H21/04 ,  C12N15/85 ,  C12N15/86 ,  C12P19/34

公开(公告)号：AU2003269962A8

公开(公告)日：2004-03-03

申请号：AU2003269962

申请日：2003-08-14

Applicant: PHARMACIA CORP

Inventor： ROSS STUART A

IPC: A61K38/00 ,  C12N15/113 ,  C07H21/02 ,  A61K48/00 ,  C07H21/04 ,  C12N15/85 ,  C12N15/86 ,  C12P19/34

公开(公告)号：CA2495037A1

公开(公告)日：2004-02-26

申请号：CA2495037

申请日：2003-08-14

Applicant: PHARMACIA CORP

Inventor： ROSS STUART A

IPC: A61K38/00 ,  C12N15/113 ,  C07H21/02 ,  A61K48/00 ,  C07H21/04 ,  C12N15/85 ,  C12N15/86 ,  C12P19/34

Abstract: Antisense compounds, compositions, and methods are provided for modulating t he expression of acyl-Coa synthesis 1, heretofore referred to as ACS1. The compositions comprise antisense compounds, particulary antisense oligonucleotides, targeted to nucleic acids encoding ACS1. Methods of using these compounds for modulation of ACS1 expression and for treatment of diseases associated with expression of ACS1 are provided.